Avalide (Irbesartan/HCTZ)

Name: Avalide
Brand: Sanofi Aventis
SKU: 0136
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Avalide Tablet

Manufacturer: Sanofi Aventis

Country: Canada

Dosage: 150 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Avalide Tablet

Manufacturer: Sanofi Aventis

Country: Turkey

Dosage: 150 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Avalide Tablet

Manufacturer: Sanofi Aventis

Country: Canada

Dosage: 300 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Avalide Tablet

Manufacturer: sanofi

Country: Turkey

Dosage: 300 mg/12.5 mg

Qty-Price (USD):

Generic Equivalent of Avalide

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Irbesartan/HCTZ Tablet

Manufacturer: Generic

Country: Canada

Dosage: 150 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Irbesartan/HCTZ Tablet

Manufacturer: Generic

Country: Canada

Dosage: 300 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Irbesartan/HCTZ Tablet

Manufacturer: Generic

Country: Canada

Dosage: 300 mg/25 mg

Qty-Price (USD):

Avalide Information

Avalide and Irbesartan/HCTZ at CanadaPharmacyOnline.com

The manufacturer of brand-name Avalide (irbesartan/hydrochlorothiazide) available at this pharmacy is Sanofi-Aventis Canada Inc. A Turkey-manufactured brand version of Avalide (also produced by Sanofi) is also available. Avalide is also known internationally as CoAprovel and Karvezide.

Generic irbesartan/hydrochlorothiazide is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards of Health Canada and the FDA. Generic irbesartan/hydrochlorothiazide is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Irbesartan/Hydrochlorothiazide:

Generic irbesartan/hydrochlorothiazide tablets contain the same active ingredients as brand-name Avalide. They must meet the same effectiveness and quality standards set by Health Canada. Studies have demonstrated that generic irbesartan/hydrochlorothiazide is bioequivalent to brand-name Avalide, meaning it has similar absorption and achieves comparable plasma concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Avalide (irbesartan/hydrochlorothiazide) is available in the following oral strengths and forms:
• Tablets: 150 mg/12.5 mg, 300 mg/12.5 mg, and 300 mg/25 mg film-coated tablets

The typical dose is one tablet taken once daily. Dosage is individualized. The maximum recommended daily dose is 300 mg/25 mg. If your blood pressure requires further control, your doctor may adjust your Avalide dose after 2 to 4 weeks of continuous therapy.

Usage:

Avalide is specifically indicated for treating high blood pressure (essential hypertension) when single-medication therapies aren't enough. Your doctor will typically prescribe it under two circumstances: Your blood pressure remained too high even after trying irbesartan or hydrochlorothiazide on their own, or if you are already taking both medications as separate pills. Your doctor is switching you to Avalide as a convenient, "all-in-one" substitution.

Mechanism of Action
Avalide combines two different high blood pressure medications that work together through complementary pathways. This means that when the two drugs are taken at the same time, they actively help each other work better than they ever could alone. Irbesartan targets your body's hormonal blood pressure controls, specifically focusing on the renin-angiotensin-aldosterone system (RAAS). This action results in wide, relaxed blood vessels (vasodilation) and a significant drop in blood pressure. Hydrochlorothiazide (HCTZ) is a "water pill" that works directly within the microscopic filtering tubes of your kidneys. It forces your body to flush sodium, chloride, and water out through your urine. Flushing out this excess fluid shrinks your total circulating blood volume, dropping your blood pressure.

Take Avalide exactly as your doctor prescribes, following the instructions in the product monograph.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Avalide, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Avalide (irbesartan/hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Avalide; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or nausea
• Dizziness, drowsiness, or light-headedness, particularly on standing up (orthostatic hypotension)
• Fatigue or weakness
• Headache
• Increased urination
• Muscle cramps
• Photosensitivity
• Runny or stuffy nose, sore throat, or upper respiratory tract infection
• Stomach pain or heartburn

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• High Potassium Levels (Hyperkalemia): Muscle weakness, severe fatigue, heart palpitations, or an irregular heartbeat.
• Kidney Failure: Sudden, noticeable decrease in urine output or significant swelling in your legs and ankles.
• Liver Problems: Yellowing of your skin or eyes (jaundice), severe abdominal pain, dark urine, or unusual fatigue.
• Low Potassium Levels (Hypokalemia): Muscle cramps, muscle weakness, abnormal heart rhythms, excessive thirst, or frequent urination.
• Severe Low Blood Pressure (Hypotension): Dizziness, light-headedness, or fainting, especially after your very first dose.
• Severe Skin Reactions and Lupus Flares: Seek emergency help for rare, widespread skin blistering or peeling conditions, such as Stevens-Johnson syndrome.
• Severe Swelling (Angioedema): Sudden swelling of your face, lips, tongue, or throat, or any sudden difficulty breathing or swallowing.
• Sudden Eye Problems (Acute Glaucoma or Nearsightedness): Sudden blurred vision, severe eye pain, or a rapid change in your sight.
• Sudden Lung Failure (ARDS or Acute Pulmonary Edema): Sudden, severe shortness of breath, a rapid cough, fever, and feeling faint from low blood oxygen.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Avalide, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Avalide/irbesartan/hydrochlorothiazide if:
• Allergies: You have a known allergy or hypersensitivity to irbesartan, hydrochlorothiazide, or any inactive ingredient in the drug.
• Anuria: Your kidneys are completely unable to produce or pass urine.
• Severe Kidney Disease: Do not use if your kidney function is severely compromised.
• Sulfa Allergies: Known hypersensitivity to other sulfonamide-derived drugs (due to the hydrochlorothiazide component)

Tell your doctor about all of your medical conditions, past and present, before starting Avalide. This is crucial as certain conditions affect the drug's safety.
• Aortic or mitral valve stenosis
• Congestive heart failure
• Diabetes mellitus
• Gout or high uric acid
• Lupus erythematosus
• Personal or family history of skin cancer or immunosuppressive therapy
• Psoriasis
• Renal artery stenosis
• Volume or salt depletion

Drug Interactions:

Before taking Avalide, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://www.sanofi.com/assets/countries/canada/docs/products/prescription-products/avalide-en.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Avalide. Avalide may interact with other medicines, including but not limited to:
• ACE Inhibitors (e.g., Ramipril, Enalapril, Perindopril, Lisinopril): Contraindicated if you have diabetic kidney disease. For all other patients, this combination is generally avoided because double-blocking this hormonal pathway heavily spikes your risk of a sudden drop in blood pressure, kidney failure, and dangerous potassium buildup without providing any extra cardiovascular benefits.
• Alcohol: Drinking alcohol can heavily amplify the blood-pressure-lowering effects of Avalide. This significantly increases your risk of experiencing severe dizziness, light-headedness, and fainting, especially when standing up quickly.
• Aliskiren (Rasilez): Completely restricted if you have diabetes or kidney disease. It is also generally avoided in all other patients due to identical high-risk complications like stroke and kidney deterioration.
• Bile Acid Resins (Cholestyramine and Colestipol): block your body from absorbing hydrochlorothiazide. Always separate these medications. Take Avalide at least 1 hour before or 4 hours after taking your cholesterol resins.
• CYP2C9 Inhibitors (e.g., Fluconazole): can increase irbesartan levels in your blood. Your doctor will monitor you for increased drug effects.
• Digoxin: The hydrochlorothiazide (HCTZ) component can flush too much potassium out of your body. If your blood potassium drops too low, it makes your heart highly sensitive to digoxin, which can trigger life-threatening irregular heart rhythms. Your doctor will closely monitor your potassium and digoxin levels.
• Lithium: The diuretic component in Avalide stops your kidneys from properly clearing out lithium, leading to a buildup in your bloodstream. Concurrent use is generally not recommended as it drastically increases the risk of severe lithium toxicity.
• NSAIDs and COX-2 Inhibitors (e.g., Ibuprofen, Naproxen, Indomethacin): can reduce the effectiveness of Avalide by blocking the natural body chemicals that help your blood vessels widen.
• Other Antihypertensive Agents & Vasodilators: Taking other blood pressure-lowering drugs alongside Avalide can produce an additive effect, further reducing blood pressure. Your doctor will closely monitor your vital signs to ensure your pressure doesn't drop too low.
• Warfarin and Anticoagulants: Hydrochlorothiazide can interact with oral anticoagulants, meaning your doctor may check your blood clotting time (INR) more frequently to adjust your therapy as needed.

Pregnancy and Breastfeeding:

Avalide is contraindicated during pregnancy. Because both of its active components can cross into the womb and interfere with your baby's development, it poses severe risks to an unborn child, including kidney damage and failure, reduced amniotic fluid, skeletal defects, and circulation issues. If you discover you are pregnant while taking Avalide, stop taking the medication immediately and contact your doctor right away. It is unknown if irbesartan passes into breast milk. Hydrochlorothiazide passes into breastmilk and may harm a nursing infant. Breastfeeding is not recommended while taking Avalide.

Use in Children:

The safety and effectiveness of Avalide (irbesartan/hydrochlorothiazide) in patients under 18 years of age have not been established, and use in this age group is not recommended.

Frequently Asked Questions about Avalide at Canada Pharmacy Online

Why is Avalide more affordable in Canada than in the United States?

Prescription drug prices, including Avalide, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Avalide I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Avalide per prescription from your doctor.

Can I buy Avalide from you over the counter?

No, Avalide requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Avalide?

Yes, generic irbesartan/hydrochlorothiazide tablets are available at this pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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