Isoptin (Verapamil SR)

Name: Isoptin
Brand: Abbott Laboratories
SKU: 1536
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Isoptin (ON BACKORDER)

Manufacturer: Abbott Laboratories

Country: India

Dosage: 120 mg

Qty-Price (USD):

Type:

Product: Isoptin (ON BACKORDER)

Manufacturer: Abbott Laboratories

Country: India

Dosage: 240 mg

Qty-Price (USD):

Generic Equivalent of Isoptin

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Verapamil SR

Manufacturer: Generic

Country: Canada

Dosage: 120 mg

Qty-Price (USD):

Isoptin Information

Isoptin and Verapamil SR at CanadaPharmacyOnline.com

The manufacturer of the brand-name Isoptin SR available at this pharmacy is Abbott Laboratories (India). Brand-name Isoptin SR was originally developed by Knoll Pharmaceuticals and has transitioned through subsequent corporate acquisitions. The current Canadian product monograph holder is BGP Pharma ULC (Viatris Canada, Etobicoke, ON). It is available in many countries worldwide, including Canada.

Generic verapamil SR is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards of Health Canada and the FDA. Generic verapamil SR is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Verapamil SR:

Generic verapamil sustained-release contains the same active ingredient as brand-name Isoptin SR. It must meet the same effectiveness and quality standards set by Health Canada. Studies have shown that generic verapamil SR is bioequivalent to brand-name Isoptin SR, meaning it has similar absorption and achieves comparable plasma concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Isoptin SR and generic verapamil SR are available in the following oral strengths:
• Tablets: 120 mg, 180 mg, and 240 mg sustained-release tablets

The usual starting adult dose of Isoptin SR for hypertension is 180 mg to 240 mg per day, taken once daily at the same time each day, in the morning. The maximum dose is 480 mg per day. Swallow the tablets whole without chewing or crushing. The drug can be taken with or without food, but taking it consistently with food may reduce gastrointestinal discomfort.

Usage:

Isoptin SR (verapamil hydrochloride sustained-release tablets) is a prescription sustained-release tablet used to treat mild-to-moderate high blood pressure (essential hypertension) in adults. "Sustained-release" means the tablet dissolves slowly, delivering a steady amount of medication into your body throughout the day. This medicine is usually prescribed to patients who have experienced uncomfortable side effects from other common blood pressure drugs, specifically "water pills" (diuretics) or beta-blockers. Your doctor may choose Isoptin SR as your very first blood pressure medication if you have other underlying health conditions that make diuretics or beta-blockers risky for you.

Mechanism of Action
Verapamil hydrochloride is a calcium ion influx inhibitor (also called a calcium channel blocker or calcium ion antagonist) of the phenylalkylamine class. It blocks calcium channels in the membranes of smooth and cardiac muscle cells, preventing calcium ions from entering the cells. This action relaxes and widens the blood vessels, reduces the heart's pumping force, and slows the heart's electrical system. Isoptin SR provides a consistent 24-hour drug delivery, ensuring steady blood levels. Take Isoptin SR exactly as your doctor prescribes, following the instructions in the product monograph. Swallow tablets whole; do not crush or chew. Take once daily in the morning, consistently with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Isoptin SR, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Isoptin SR (verapamil hydrochloride). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Isoptin SR; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Constipation (the most common side effect)
• Dizziness or light-headedness
• Edema (swelling) of the lower legs or ankles
• Fatigue or tiredness
• Flushing (skin redness and warmth)
• Headache
• Nausea
• Shortness of breath

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Atrioventricular (AV) block or conduction disturbances: Symptoms include an unusually slow or irregular pulse, severe dizziness, near-fainting, or fainting.
• Bradycardia
• Gingival hyperplasia: Overgrowth of the gum tissue.
• Heart failure or pulmonary edema: Sudden weight gain, increasing shortness of breath, or difficulty breathing while lying flat.
• Hypotension
• Liver injury: Jaundice (yellowing of the skin or eyes), dark urine, malaise, fever, or right upper abdominal pain.
• Severe allergic reaction (Anaphylaxis): Hives, rash, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Severe skin reactions: Widespread red rash with blistering or peeling (Stevens-Johnson syndrome or erythema multiforme).
• Ventricular arrhythmias: Palpitations, rapid irregular heartbeat, or fainting.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Isoptin SR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Isoptin SR/verapamil hydrochloride if:
• Accessory bypass tract with atrial flutter or fibrillation (Wolff-Parkinson-White or Lown-Ganong-Levine syndromes)
• Allergies: You have a known hypersensitivity to verapamil hydrochloride or any of the formulation's ingredients.
• Cardiogenic shock.
• Complicated myocardial infarction
• Concurrent flibanserin use (Addyi)
• Concurrent ivabradine use (Lancora)
• Second or third degree atrioventricular (AV) block.
• Severe hypotension.
• Sick sinus syndrome.

Tell your doctor about all of your medical conditions, past and present, before starting Isoptin SR. This is crucial as certain conditions affect the drug's safety.
• First-degree AV block
• Heart failure or severe heart problems
• Hepatic impairment
• Hypertrophic cardiomyopathy
• Myasthenia gravis, Lambert-Eaton syndrome, or advanced Duchenne muscular dystrophy
• Renal impairment

Drug Interactions:

Before taking Isoptin SR, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the patient medication information at https://www.viatris.ca/-/media/project/common/viatrisca/pdf/brand-and-speciality/isoptinsr-pi-en.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Isoptin SR. Isoptin SR may interact with other medicines, including but not limited to:
• Alcohol: Verapamil may significantly increase blood alcohol levels and prolong the intoxicating effects of alcohol by inhibiting alcohol metabolism. Limit or avoid alcohol.
• Antiarrhythmic drugs (e.g., amiodarone, disopyramide, quinidine, flecainide): Concomitant use with quinidine in patients with hypertrophic cardiomyopathy has caused severe hypotension; this combination should generally be avoided. Verapamil also inhibits the hepatic clearance of quinidine.
• Antiepileptic drugs (carbamazepine, phenytoin, phenobarbital, valproate): CYP3A4 inducers such as carbamazepine, phenytoin, and phenobarbital increase verapamil metabolism, reducing its effectiveness.
• Beta-blockers (e.g., metoprolol, atenolol, propranolol): Concurrent use can cause severe bradycardia, AV block, heart failure, and hypotension.
• CYP3A4 inhibitors (e.g., clarithromycin, erythromycin, itraconazole, ketoconazole, ritonavir, grapefruit juice): These drugs inhibit the metabolism of verapamil, increasing its concentrations and risk of side effects, including excessive heart rate reduction and hypotension.
• Digoxin: Verapamil significantly increases digoxin levels in the blood.
• Ivabradine: Concomitant use is strictly contraindicated due to a massive increase in ivabradine exposure and the risk of severe, additive heart rate lowering (bradycardia).
• Lithium: Verapamil may reduce lithium levels, potentially reducing its effectiveness, while also increasing sensitivity to lithium neurotoxicity.

Pregnancy and Breastfeeding:

There are no adequate, well-controlled studies of Isoptin SR in pregnant women. Verapamil hydrochloride crosses the placental barrier and can be detected in umbilical vein blood at delivery. Isoptin SR is not recommended for use during pregnancy unless the potential benefits clearly outweigh the potential risks to the mother and fetus. Verapamil hydrochloride is excreted into human breast milk. Because of the potential for adverse reactions in nursing infants, breastfeeding should be discontinued while taking Isoptin SR. Discuss the risks and benefits of breastfeeding with your doctor.

Use in Children:

The safety and efficacy of Isoptin SR in patients under 18 years of age have not been established. Use in this age group is not recommended.

Frequently Asked Questions about Isoptin SR at Canada Pharmacy Online

Why is Isoptin SR more affordable in Canada than in the United States?

Prescription drug prices, including Isoptin SR, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Isoptin SR I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Isoptin SR per prescription from your doctor.

Can I buy Isoptin SR from you over the counter?

No, Isoptin SR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Isoptin SR?

Yes, generic verapamil SR is available at this pharmacy.

Blog Post:

Natural Ways to Lower Your Blood Pressure

Latest News:

FDA Approves AstraZeneca Drug With New Approach to Lowering High Blood Pressure (news published May 18, 2026)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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