Lopressor SR (Metoprolol Tartrate Prolonged Release)

Name: Lopressor SR
Brand: AstraZeneca
SKU: 1610
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Lopressor SR Tablet

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Lopressor SR Tablet (ON BACKORDER)

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Lopressor SR Tablet

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Lopressor SR Tablet (ON BACKORDER)

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 200 mg

Qty-Price (USD):

Generic Equivalent of Lopressor SR

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Metoprolol Tartrate Prolonged Release Tablet

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Lopressor SR Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on May 28, 2026.

Lopressor SR and Metoprolol Tartrate Prolonged Release at CanadaPharmacyOnline.com

The manufacturer of the brand-name Lopressor SR available at this pharmacy is Novartis Pharmaceuticals Canada Inc. (Dorval, Québec), a subsidiary of the global Novartis Group. An AstraZeneca-manufactured version of Lopressor SR (produced in Turkey) is also available at this pharmacy.

Generic metoprolol tartrate prolonged-release is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards of Health Canada and the FDA. Common generic manufacturers include Sandoz. Generic metoprolol tartrate prolonged-release is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Metoprolol Tartrate Prolonged Release:

Generic metoprolol tartrate prolonged-release (Sandoz Metoprolol SR) contains the same active ingredient as brand-name Lopressor SR. It must meet the same effectiveness and quality standards set by Health Canada. Studies have demonstrated that generic metoprolol tartrate prolonged-release is bioequivalent to Lopressor SR, meaning it has similar absorption and achieves comparable plasma concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Lopressor SR is available in the following oral strengths and forms:
• Slow-release tablets: 50 mg, 100 mg, and 200 mg

The generic metoprolol tartrate is available in:
• Prolonged-release tablets: 100 mg

Dosage is individualized. Lopressor SR tablets must be swallowed whole, without chewing or crushing, preferably with or immediately after a meal. They should be taken once daily in the morning.

Usage:

Lopressor SR (metoprolol tartrate) is a cardioselective beta-blocker available as a prolonged-release tablet that slowly releases medication over time. It is prescribed for three major cardiovascular conditions: managing mild-to-moderate high blood pressure (hypertension), providing long-term prevention of chest pain (angina pectoris) caused by reduced blood flow to the heart, and improving survival rates in stable patients following a heart attack (acute myocardial infarction). It is not meant for the emergency treatment of sudden, severe spikes in blood pressure.

Mechanism of Action
Metoprolol tartrate is a competitive antagonist of catecholamines (adrenaline/epinephrine and noradrenaline/norepinephrine) at beta-1 adrenergic receptors. By blocking these receptors in the heart, metoprolol produces several beneficial cardiovascular effects, including lowering heart rate, reducing the heart’s workload, and lowering blood pressure. It also prevents chest pain (angina) and protects the heart after a heart attack. Lopressor SR is a prolonged-release tablet that delivers the medication steadily into your system. It takes 4 to 5 hours to reach peak levels, providing consistent, smooth heart protection across a full 24-hour window.

Take Lopressor SR exactly as your doctor prescribes, following the instructions in the product monograph. Swallow tablets whole with or after a meal, once daily in the morning. Never crush or chew the tablets.

Do not stop taking Lopressor SR suddenly without consulting your doctor. Abruptly stopping can cause a severe rebound worsening of angina, dangerous heart rhythms, or a heart attack. If the medication needs to be stopped, your doctor will guide you through a gradual dose-tapering schedule over 1 to 2 weeks.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Lopressor SR, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Lopressor SR (metoprolol tartrate). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Lopressor SR; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Cold hands and feet
• Diarrhea
• Dizziness or light-headedness
• Drowsiness or fatigue
• Dry mouth
• Gastrointestinal disturbances, including nausea, abdominal pain, or constipation
• Headache
• Insomnia or sleep disturbances, including vivid dreams or nightmares
• Mood changes or depression
• Shortness of breath or exertional breathlessness
• Skin reactions, including rash or increased sweating
• Slow heart rate
• Weight gain

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Atrioventricular (AV) block or worsening heart block: Symptoms include very slow pulse, fainting, dizziness, or chest pain.
• Bronchospasm: Sudden onset or worsening of wheezing, shortness of breath, or chest tightness, particularly in patients with asthma or chronic obstructive pulmonary disease (COPD).
• Heart failure: Signs include sudden weight gain, swelling of the ankles or legs, or increasing shortness of breath at rest or when lying flat.
• Hypoglycemia masking: In diabetic patients on insulin or oral hypoglycaemic agents, metoprolol can mask the warning signs of hypoglycemia (particularly tachycardia).
• Hypotension: Severe dizziness, fainting, or an unexpectedly low blood pressure reading.
• Peripheral arterial ischemia: Blue discoloration of fingers or toes (cyanosis), or symptoms of worsening peripheral arterial disease, such as cold, painful, or numb extremities.
• Severe allergic reaction (Anaphylaxis): Hives, rash, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Severe psychiatric symptoms: Confusion, hallucinations, or severe depression with suicidal ideation.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Lopressor SR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Lopressor SR/metoprolol tartrate if:
• Allergies: You have a known hypersensitivity to metoprolol tartrate, any other beta-blocker, or any ingredient in the formulation.
• Anesthesia with myocardial depressant agents (e.g., ether): Lopressor SR should not be used with anesthetic agents known to depress myocardial function.
• Cardiogenic shock.
• Overt (decompensated) heart failure.
• Prinzmetal’s angina
• Second or third degree atrioventricular (AV) block.
• Sick sinus syndrome.
• Sinus bradycardia

Tell your doctor about all of your medical conditions, past and present, before starting Lopressor SR. This is crucial as certain conditions require extra monitoring or special precautions.
• Asthma or COPD
• Diabetes mellitus
• First-degree AV block
• Heart failure
• Hepatic impairment
• Hyperthyroidism
• Myasthenia gravis
• Peripheral arterial disease
• Psoriasis
• Renal impairment (severe)

Drug Interactions:

Before taking Lopressor SR, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://www.novartis.com/ca-en/sites/novartis_ca/files/lopresor_scrip_e.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Lopressor SR. Lopressor SR may interact with other medicines, including but not limited to:
• Alcohol: Concurrent use of alcohol and antihypertensives, including metoprolol, may aggravate the signs and symptoms of overdose (hypotension, bradycardia). Limit alcohol intake.
• Antiarrhythmic agents (e.g., amiodarone, disopyramide, quinidine): Additive effects on heart rate and conduction. The combination can cause severe bradycardia or heart block.
• Antidiabetic agents (insulin and oral hypoglycemics): The blood-glucose-lowering effect may be enhanced, and the symptoms of hypoglycemia (particularly tachycardia) may be masked.
• Antihypertensive drugs
• Barbiturates and other CNS depressants: Concomitant use of barbiturates aggravates the signs and symptoms of overdose.
• Calcium channel blockers — verapamil and diltiazem (non-dihydropyridine type): These drugs and metoprolol have additive effects in slowing AV conduction and reducing heart rate and myocardial contractility. Concurrent use significantly increases the risk of severe bradycardia, heart block, and cardiac failure.
• Clonidine: Metoprolol may worsen the rebound hypertension that occurs after clonidine withdrawal.
• CYP2D6 inhibitors (such as quinidine, fluoxetine, paroxetine, and propafenone): Metoprolol is primarily metabolized by CYP2D6. Drugs that inhibit CYP2D6 can significantly increase metoprolol blood levels, reducing its cardioselectivity and increasing the risk of side effects.
• Digitalis glycosides (e.g., digoxin): Both digitalis and beta-blockers depress AV conduction and slow heart rate. Concomitant use significantly increases the risk of bradycardia and heart block.
• Epinephrine (adrenaline)
• NSAIDs (non-steroidal anti-inflammatory drugs, e.g., ibuprofen, naproxen, indomethacin): NSAIDs can attenuate the antihypertensive effect of beta-blockers, including metoprolol, by inhibiting prostaglandin synthesis. Monitor blood pressure if NSAIDs are used concurrently.
• Rifampicin (rifampin) and other enzyme inducers: Rifampicin reduces the effectiveness of Lopressor SR.

Pregnancy and Breastfeeding:

Lopressor SR should not be used during pregnancy unless it is clearly necessary and the potential benefit justifies the potential risk to the fetus. If metoprolol tartrate is used during pregnancy, the newborn must be carefully monitored for bradycardia, hypoglycemia, and respiratory depression in the first 24–48 hours after birth.

Metoprolol tartrate passes into breast milk. Caution is advised during breastfeeding. Discuss the risks and benefits of breastfeeding with your doctor if you are taking Lopressor SR.

Use in Children:

The safety and efficacy of metoprolol tartrate in pediatric patients have not been established.

Frequently Asked Questions about Lopressor SR at Canada Pharmacy Online

Why is Lopressor SR more affordable in Canada than in the United States?

Prescription drug prices, including Lopressor SR, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Lopressor SR I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Lopressor SR per prescription from your doctor.

Can I buy Lopressor SR from you over the counter?

No, Lopressor SR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Lopressor SR?

Yes, a generic alternative is available: Sandoz Metoprolol SR (metoprolol tartrate prolonged-release tablets 100 mg).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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