Seasonale (Levonorgestrel/Ethinyl Estradiol)

Name: Seasonale
Brand: Teva
SKU: 6547
Availability: InStock

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Qty-Price (USD)

Type:

Product: Seasonale 91 Tablets Pack (ON BACKORDER)

Manufacturer: Teva

Country: Canada

Dosage: 0.15 mg/0.03 mg

Qty-Price (USD):

Generic Equivalent of Seasonale

Type

Product

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There is no generic product of Seasonale.

Seasonale Information

Seasonale at CanadaPharmacyOnline.com

The manufacturer of brand-name Seasonale is Teva Canada Limited (Teva Canada Innovation, Montréal, Québec), a subsidiary of Teva Pharmaceuticals, one of the world's leading generic and specialty pharmaceutical companies. Seasonale is currently available at this pharmacy as the brand-name product manufactured by Teva Canada.

There is currently no generic equivalent available for Seasonale at this pharmacy.

Dosage:

Seasonale is available in the following oral form and strength:
• Extended-Cycle Tablet Dispenser (91-pill pack / 13-week supply): 84 pink active tablets, each containing 0.15 mg levonorgestrel and 0.03 mg ethinyl estradiol. 7 white inert tablets (placebo, no active hormones).

The dosage of Seasonale is one pink (active) tablet taken orally at the same time each day for 84 consecutive days, followed by one white (placebo) tablet daily for 7 days, for a total of 91 days (13 weeks) per cycle. Women can expect approximately 4 scheduled withdrawal bleeding periods per year, occurring during the 7 placebo tablet days. You may start Seasonale on the first day of your period (Day 1 Start) for immediate protection, or on the first Sunday after your period begins (Sunday Start), which requires a backup contraceptive for the first 7 days.

Usage:

Seasonale is an extended-cycle combination oral contraceptive (COC) indicated for use by females of reproductive potential to prevent pregnancy. It belongs to the class of 84/7 extended-cycle oral contraceptives that reduce the frequency of scheduled withdrawal bleeding from the conventional 13 periods per year (monthly) to approximately 4 periods per year (quarterly). As a monophasic formulation, each active tablet contains a fixed dose of hormones, providing consistent hormone levels throughout the 84-day active phase.

Before starting Seasonale, women should weigh the benefit of fewer scheduled menstrual periods (4 per year instead of 13) against the likelihood of increased unscheduled (breakthrough) bleeding and spotting, particularly in the first two to three cycles of use. This unscheduled bleeding typically decreases over time as the body adjusts to the extended cycle regimen. Non-contraceptive benefits common to combination oral contraceptives may include lighter scheduled periods, reduced menstrual cramping (dysmenorrhea), and potential long-term reductions in the risk of ovarian and endometrial cancers. Seasonale does not protect against HIV (AIDS) or other sexually transmitted infections (STIs).

Mechanism of Action
Seasonale prevents pregnancy through the complementary actions of its two active hormones. Levonorgestrel is a second-generation synthetic progestin (a synthetic analog of progesterone) and is the primary contraceptive agent. It suppresses the hypothalamic-pituitary-ovarian axis, specifically inhibiting the surge of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) that would otherwise trigger ovulation. Ethinyl estradiol is a synthetic estrogen that reinforces ovulation suppression by inhibiting follicular development. Because menstruation is a response to hormone withdrawal rather than a physiologically necessary event, extending the active hormone phase to 84 days delays the hormone-free interval that triggers withdrawal bleeding. During the 7-day placebo phase, hormone levels fall, and a withdrawal bleed occurs.

Take Seasonale exactly as your doctor prescribes, according to the instructions in the product monograph. Tablets must be taken in the order directed on the Extended-Cycle Tablet Dispenser, at the same time each day, and at intervals not exceeding 24 hours.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Seasonale, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Seasonale (levonorgestrel/ethinyl estradiol). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Seasonale; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Acne (may improve or worsen)
• Breast pain or tenderness
• Changes in vaginal discharge
• Decreased sex drive (libido)
• Headache
• Loss of scalp hair
• Nausea
• Photosensitivity: Your skin may become more sensitive to sunlight and tanning beds. Use sunscreen and wear protective clothing.
• Unscheduled (breakthrough) bleeding or spotting
• Weight changes

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following:
• Blood Clots (Venous or Arterial Thromboembolism): Pain, swelling, redness, or warmth in the leg, sudden shortness of breath or chest pain, coughing up blood.
• High Blood Pressure: Monitor blood pressure regularly; discontinue if it rises significantly.
• Liver Problems: Yellowing of the skin or eyes (jaundice), dark urine, severe upper right stomach pain, loss of appetite.
• Severe Abdominal Pain: May indicate a liver tumor (hepatic adenoma) or gallbladder disease; discontinue and evaluate.
• Severe Allergic Reaction (Anaphylaxis): Hives, rash, itching, or swelling of the face, lips, tongue, or throat, difficulty breathing.
• Stroke or Heart Attack: Sudden severe headache with no known cause, sudden numbness or weakness of the face, arm, or leg (especially on one side of the body), sudden confusion, trouble speaking or understanding speech
• Visual Changes: Unexplained sudden loss of vision, blurred vision, double vision, bulging eyes (proptosis), or retinal changes.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Seasonale, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Seasonale/levonorgestrel/ethinyl estradiol if:
• Active Liver Disease or Liver Tumours: Including hepatitis with abnormal liver function, benign or malignant liver tumours, or a history of jaundice caused by oral contraceptives or pregnancy (cholestatic jaundice of pregnancy).
• Allergies: Known hypersensitivity to levonorgestrel, ethinyl estradiol, or any ingredient in the tablet.
• Breast Cancer or Other Hormone-Sensitive Cancer: Known or suspected breast cancer, carcinoma of the endometrium, or other estrogen- or progesterone-dependent neoplasms.
• Diabetes Mellitus with Vascular Involvement: Such as nephropathy, retinopathy, neuropathy, or other vascular disease.
• Hereditary or Acquired Thrombophilia: Such as Factor V Leiden mutation, antiphospholipid syndrome, or protein C, protein S, or antithrombin deficiency.
• History of Blood Clots or Stroke: You have a current or past history of deep vein thrombosis (DVT), pulmonary embolism (PE), stroke, transient ischemic attack (TIA), or heart attack, or are known to have a high risk of arterial or venous thrombotic diseases.
• Migraine with Aura: A history of migraines with focal neurological symptoms (visual disturbances, tingling, weakness).
• Pregnancy: Seasonale is contraindicated during pregnancy. Discontinue immediately if pregnancy is confirmed.
• Uncontrolled High Blood Pressure: Seasonale should not be used in women with severe or uncontrolled hypertension.
• Undiagnosed Abnormal Vaginal Bleeding: Any cause of abnormal uterine or vaginal bleeding that has not been investigated and diagnosed.
• Valvular Heart Disease with Complications, or a history of coronary artery disease.

Tell your doctor about all of your medical conditions, past and present, before starting Seasonale. This is crucial as certain conditions affect the drug's safety.
• A history of depression or mood disorders: discontinue if serious depression recurs
• Diabetes mellitus
• Hereditary angioedema
• Hyperlipidemia or a family history of hypertriglyceridaemia: certain progestins may elevate LDL and triglyceride levels
• Inflammatory bowel disease (Crohn's disease or ulcerative colitis): absorption may be impaired
• Well-controlled hypertension: monitor blood pressure regularly. Discontinue if a significant rise occurs.

Drug Interactions:

Before taking Seasonale, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00074600.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Seasonale. Seasonale may interact with other medicines, including but not limited to:
• Anastrozole, Exemestane, and Other Aromatase Inhibitors: Ethinyl estradiol may interfere with the action of anti-cancer drugs. Do not use them together.
• Antiretroviral Drugs (HIV medications): Many HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors (NNRTIs) significantly alter (either increase or decrease) plasma estrogen and progestin levels. Discuss contraceptive options carefully with your doctor if you are on HIV medications.
• Cyclosporine, Theophylline, and Prednisolone: Ethinyl estradiol may inhibit the metabolism of these drugs, increasing their plasma concentrations and risk of toxicity. Dose adjustments of these drugs may be needed.
• Enzyme Inducers (Drugs or Supplements That May Decrease Effectiveness): These drugs speed up the liver's breakdown of the contraceptive hormones, potentially reducing their blood levels, decreasing contraceptive effectiveness, and increasing breakthrough bleeding. Examples include: certain anticonvulsants (phenytoin, carbamazepine, oxcarbazepine, topiramate, felbamate, phenobarbital, primidone), the anti-tuberculosis antibiotic rifampin (rifampicin), certain antiretroviral drugs for HIV, and the herbal supplement St. John's Wort.
• Vitamin C and Paracetamol (Tylenol): May increase plasma levels of ethinyl estradiol, potentially increasing estrogen-related side effects if taken regularly at high doses. Conversely, Seasonale may make Tylenol (acetaminophen) less effective, so your usual pain-relief dose may wear off faster than expected.
• Warfarin: Estrogens may increase the risk of thrombosis, potentially interfering with warfarin's anticoagulant effect. Monitoring of clotting time (INR) is advisable.

Pregnancy and Breastfeeding:

Seasonale is contraindicated during pregnancy and must be discontinued immediately if pregnancy is confirmed. Seasonale is not recommended for use during breastfeeding. Small amounts of oral contraceptive steroids and their metabolites have been identified in breast milk and may affect the nursing infant. In addition, estrogen-containing COCs can decrease the quantity and quality of breast milk in nursing mothers. If a breastfeeding woman requires contraception, a progestin-only method is generally preferred until breastfeeding is complete or well-established. Consult your doctor about the most appropriate contraceptive option if you are breastfeeding.

Use in Children:

Seasonale is not indicated for use before menarche (the onset of the first menstrual period). Do not use this medicine in children under 18 years old.

Frequently Asked Questions about Seasonale at Canada Pharmacy Online

Why is Seasonale more affordable in Canada than in the United States?

Prescription drug prices, including Seasonale, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Seasonale I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Seasonale per prescription from your doctor.

Can I buy Seasonale from you over the counter?

No, Seasonale requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Seasonale?

There is currently no generic equivalent available for Seasonale at this pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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