Colcrys / Colchicine (Colchicine)

Name: Colcrys
Brand: Generic
SKU: 0253
Availability: InStock

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Product

Manufacturer

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Qty-Price (USD)

There is no brand product of Colcrys / Colchicine.

Generic Equivalent of Colcrys / Colchicine

Type

Product

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Type:

Product: Colchicine

Manufacturer: Generic

Country: Turkey

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Colchicine

Manufacturer: Generic

Country: United Kingdom

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Colchicine

Manufacturer: Generic

Country: Canada

Dosage: 0.6 mg

Qty-Price (USD):

Colcrys / Colchicine Information

medically reviewed by Carol Hou (BSc. Pharm) on August 19, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Colchicine at CanadaPharmacyOnline.com

Brand Colcrys is currently unavailable (at this pharmacy).

Generic colchicine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturers of your dispensed medication may vary.

Important Information about Generic Colchicine

Studies have shown that generic drugs in general are required to demonstrate bioequivalence to their brand-name counterparts, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. While the brand-name drug Colcrys had a unique history as the only FDA-approved oral colchicine product for some time, therapeutically equivalent generic versions are now available. These generics, including an "authorized generic" from the same manufacturer, are considered interchangeable with Colcrys.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts.

Dosage:

The generic Colchicine is available in 0.5 mg and 0.6 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Colcrys (colchicine) is a medication mainly used to treat and prevent painful gout attacks caused by inflammation from uric acid crystals in the joints, working by reducing this inflammation. Besides gout, Colcrys is also prescribed for Familial Mediterranean Fever (FMF), a rare inflammatory disorder. A low-dose form is sometimes used to lower the risk of severe heart problems in certain adults with specific heart conditions or risk factors. It's important to remember that Colcrys specifically targets these conditions and is not a general pain reliever.

Mechanism of Action:
Colcrys (colchicine) helps reduce inflammation at a cellular level, mainly by interfering with specific white blood cells called neutrophils and blocking a key inflammatory pathway known as the NLRP3 inflammasome. In simple terms, it works by decreasing how immune cells move to inflamed areas and lowering the production of strong inflammatory signals. This action helps diminish swelling, pain, and redness in conditions like gout, without functioning as a typical painkiller.

Take Colcrys (colchicine) exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Colcrys, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Colcrys (colchicine). It is not an exhaustive list, and individuals can vary.

Common side effects – These are some common side effects of Colcrys, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal cramps or pain
• Diarrhea
• Nausea
• Vomiting

Other Potential Side Effects (less common):
• Alopecia (hair loss)
• Bone marrow suppression (leading to low blood cell counts, which can increase the risk of infection, bleeding, or fatigue)
• Dermatitis (skin inflammation, rash)
• Fatigue
• Headache
• Muscle weakness or pain (myopathy)
• Peripheral neuropathy (nerve damage causing numbness, tingling, or weakness in hands/feet)
• Rash
• Stomach upset (indigestion)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reaction (e.g., hives, difficulty breathing, swelling of the face, lips, tongue, or throat)
• Blood disorders (signs include unusual bleeding or bruising, fever, chills, sore throat, extreme tiredness or weakness, pale skin)
• Muscle pain or weakness with dark urine (rhabdomyolysis, a sign of severe muscle breakdown)
• Signs of liver problems (e.g., yellowing of the skin or eyes, dark urine, severe stomach pain, unusual fatigue)

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Colcrys, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Colcrys should not be used if you:
• Are allergic to colchicine or any of its ingredients.
• Have kidney or liver problems and are also taking certain medications (such as potent CYP3A4 inhibitors or P-glycoprotein inhibitors).
• Have severe kidney or liver problems.

Drug Interactions:

Before taking Colcrys, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information | Takeda Pharmaceuticals: https://content.takeda.com/?contenttype=PI&product=COL&language=ENG&country=GBL&documentnumber=1

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, or significant dietary changes, as these could potentially interact with Colcrys. Colcrys may interact with other medicines, but is not limited to:
• CYP3A4 Inhibitors (strong): These medications can significantly increase colchicine levels in the blood, leading to a higher risk of toxicity, including severe muscle damage, bone marrow suppression, and multi-organ failure. Co-administration with potent CYP3A4 inhibitors is often contraindicated in patients with kidney or liver impairment and requires dose adjustment or avoidance in others. Examples include:
o Antifungals (e.g., itraconazole, ketoconazole, posaconazole, voriconazole)
o Antibiotics (e.g., clarithromycin, erythromycin, telithromycin)
o Antidepressants (e.g., nefazodone)
o HIV medications (e.g., atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir)
o Heart medications (e.g., diltiazem, verapamil)
o Ranolazine (for chronic angina)
• Digoxin: Co-administration with colchicine may increase the plasma concentrations of both drugs due to competitive inhibition of the P-glycoprotein (P-gp) efflux transporter. This can increase the risk of side effects, including severe muscle damage. Monitoring may be necessary, and dose adjustments of colchicine might be required.
• Fibrates (e.g., fenofibrate, gemfibrozil): These cholesterol-lowering medications can independently cause muscle problems (myopathy). Combining them with colchicine, which also has a risk of myopathy and rhabdomyolysis (severe muscle breakdown), can increase the risk of these serious muscle-related side effects. Close monitoring and possible dose adjustments are recommended.
• Grapefruit (and Grapefruit Juice): Grapefruit can inhibit CYP3A4 and P-gp, leading to increased colchicine levels and a higher risk of toxicity. It's generally recommended to avoid grapefruit and grapefruit juice while taking colchicine.
• P-glycoprotein (P-gp) Inhibitors: These medications can increase the absorption and reduce the excretion of colchicine, leading to higher blood levels and increased risk of toxicity. As with CYP3A4 inhibitors, co-administration with P-gp inhibitors is often contraindicated in patients with kidney or liver impairment and requires careful consideration or dose adjustment in others. Examples include:
o Amiodarone (for heart rhythm disorders)
o Cyclosporine (an immunosuppressant)
o Ranolazine (for chronic angina)
o Verapamil (for high blood pressure/heart conditions)
• Statins (e.g., atorvastatin, fluvastatin, lovastatin, pravastatin, simvastatin): Like fibrates, statins are cholesterol-lowering medications known to cause muscle pain or weakness (myopathy). Combining them with colchicine can significantly increase the risk of severe muscle damage, including rhabdomyolysis. Monitoring for muscle symptoms and potential dose adjustments of either medication is essential.

Alcohol:
While there isn't a direct chemical interaction that alters colchicine's metabolism, both colchicine and alcohol can cause gastrointestinal side effects (like nausea, vomiting, diarrhea) and can potentially affect the liver. Combining them might worsen these effects, and some sources suggest an increased risk of gastrointestinal bleeding. Caution is advised.

Pregnancy and Breastfeeding:

If you're pregnant, using Colcrys (colchicine) should be a decision made with your doctor, balancing the need to control conditions like gout or Familial Mediterranean Fever with any potential, though uncertain, risks to the baby. While animal studies have shown concerns at high doses, human studies generally haven't linked colchicine to an increased risk of significant congenital disabilities. For breastfeeding parents, Colcrys does pass into breast milk in small amounts, but typically it's considered safe to use, with no consistent harmful effects reported in breastfed infants. Still, it's always wise to discuss your situation with your doctor to ensure the safest treatment plan for you and your baby.

Use in Children:

Colcrys (colchicine) can be used in children, but generally for specific conditions and ages. It's a key treatment for Familial Mediterranean Fever (FMF) in children typically aged four and older, helping to prevent painful episodes. For gout attacks, it's usually only considered for adolescents aged 16 and up. It's crucial for parents and caregivers to strictly follow the doctor's dosing instructions and keep this medication out of reach, as even small overdoses can be severe for children. Your child's doctor will carefully monitor them for any side effects during treatment.

Frequently Asked Questions about Colcrys at Canada Pharmacy Online:

Why is Colcrys more affordable in Canada than in the United States?

Prescription drug prices, including Colcrys, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

What is Colchicine used for in pets?

Colchicine for pets is an oral medication used to reduce scar tissue formation as a consequence of inflammation. It is most commonly prescribed for dogs with chronic active hepatitis to preserve as much functional liver tissue as possible.

Is there a limit on how many Colcrys tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Colchicine at one time, as per your doctor's prescription.

Can I buy Colcrys over the counter from you?

No, Colcrys requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Colcrys?

Yes, there is a generic alternative for this product, called Colchicine.

How does Colcrys work for gout?

For gout, Colcrys (Colchicine) works by reducing the inflammation caused by crystals of uric acid in your joints.

Blog Post:

Gout: An Ancient Disease of Kings, A Modern Problem for Boomers and Millennials

Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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