Crestor (Rosuvastatin)

Name: Crestor
Brand: AstraZeneca
SKU: 0294
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Crestor (ON BACKORDER)

Manufacturer: AstraZeneca

Country: India

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Crestor (ON BACKORDER)

Manufacturer: AstraZeneca

Country: India

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Crestor

Manufacturer: AstraZeneca

Country: Australia

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Crestor (ON BACKORDER)

Manufacturer: AstraZeneca

Country: Turkey

Dosage: 40 mg

Qty-Price (USD):

Generic Equivalent of Crestor

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: United Kingdom

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin (ON BACKORDER)

Manufacturer: Generic

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Rosuvastatin

Manufacturer: Generic

Country: United Kingdom

Dosage: 40 mg

Qty-Price (USD):

Crestor Information

medically reviewed by Carol Hou (BSc. Pharm) on July 1, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Crestor and Rosuvastatin at CanadaPharmacyOnline.com

The brand name Crestor, manufactured by AstraZeneca, is available in many countries worldwide, including Canada, India, Turkey, and Australia.

Generic rosuvastatin is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Rosuvastatin:

Generic rosuvastatin contains the same active ingredient as brand-name Crestor and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Crestor. Studies have shown that generic rosuvastatin is bioequivalent to brand-name Crestor, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

The brand Crestor and generic rosuvastatin are commonly available in 5 mg, 10 mg, 20 mg, and 40 mg oral tablets.

It's important to note that the 40 mg dose is typically reserved for specific situations and is associated with a higher risk of muscle-related side effects.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Crestor (rosuvastatin) is primarily used to manage cholesterol levels and significantly reduce the risk of cardiovascular disease. Its main applications include lowering "bad" LDL cholesterol and triglycerides, and it has a modest effect on increasing "good" HDL cholesterol, slowing the progression of atherosclerosis (plaque buildup in arteries). These actions collectively help prevent major cardiovascular events such as heart attacks, strokes, and the need for heart revascularization procedures. Additionally, Crestor is prescribed for adult patients and certain pediatric patients with genetic conditions like familial hypercholesterolemia, which causes extremely high cholesterol levels. This includes, for example, patients aged 6 years and older with homozygous familial hypercholesterolemia (HoFH) and patients aged 8 years and older with heterozygous familial hypercholesterolemia (HeFH). However, specific age recommendations can vary based on individual patient needs and clinical guidelines. Crestor is always used as an adjunct to a healthy diet and exercise regimen.

Mechanism of Action
Rosuvastatin, a statin medication, primarily acts by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol biosynthesis. This inhibition reduces the liver's internal cholesterol production, prompting an upregulation of LDL receptors on hepatocyte surfaces. Consequently, the liver efficiently clears more LDL cholesterol from the bloodstream, alongside decreasing VLDL production. These combined actions significantly reduce total cholesterol, LDL cholesterol, and triglycerides while offering beneficial pleiotropic effects such as anti-inflammatory and antioxidant properties, ultimately lowering cardiovascular risk.

Take Crestor exactly as your doctor prescribes, following the instructions in the official Crestor product monograph | AstraZeneca.ca. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Crestor, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Crestor (rosuvastatin). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Crestor, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Constipation
• Dizziness
• Headache
• Joint pain
• Muscle aches and pains (myalgia)
• Nausea
• Protein in the urine (proteinuria): This laboratory finding can occur, especially with higher doses of rosuvastatin. While often asymptomatic and transient and typically not indicative of significant kidney damage, persistent proteinuria warrants further investigation and monitoring of renal function, particularly to rule out other underlying kidney conditions or concerns about rhabdomyolysis.
• Slight increase in blood sugar levels and risk of new-onset type 2 diabetes: While the rise in blood sugar is often modest, statin use, especially at higher doses and in individuals with pre-existing risk factors (e.g., metabolic syndrome, pre-diabetes), has been associated with a small increased risk of developing new-onset type 2 diabetes. Despite this, the cardiovascular benefits of statins typically outweigh this risk. Regular monitoring of blood glucose is recommended, especially for at-risk individuals.
• Weakness (asthenia)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic Reaction: Though rare, a severe allergic reaction (anaphylaxis) is possible, with symptoms like swelling of the face, throat, tongue, lips, or eyes, difficulty breathing, wheezing, rash, hives, or blisters. Seek emergency medical help immediately.
• Cognitive Impairment: There have been isolated post-marketing reports of memory loss, forgetfulness, confusion, and amnesia with statin use. However, large-scale clinical trials and comprehensive reviews have not consistently demonstrated a causal link between statin use and significant cognitive impairment.
• Kidney Damage: This can occur as a severe complication of muscle breakdown (rhabdomyolysis), which can lead to acute kidney injury.
• Liver Problems: Crestor can increase liver enzymes, which can indicate liver damage. (Symptoms include unusual tiredness or weakness, loss of appetite, upper belly pain, dark urine, or yellowing of the skin or the whites of your eyes (jaundice). Your doctor will likely do blood tests to check your liver function before and during treatment.
• Muscle Problems (Myopathy, Rhabdomyolysis): This is one of the most concerning side effects. It can range from muscle pain, tenderness, or weakness to a severe breakdown of muscle tissue called rhabdomyolysis. Rhabdomyolysis can lead to kidney damage and, rarely, can be fatal.
o Symptoms to watch for: Unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever, unusual tiredness, or dark-colored urine. o Risk factors: Higher doses of Crestor, older age (65+), uncontrolled hypothyroidism, kidney problems, and certain other medications can increase the risk. People of Asian descent may also have a higher risk of muscle problems and often require a lower starting dose.
• Pancreatitis: Inflammation of the pancreas. While extremely rare, there have been post-marketing reports of pancreatitis occurring in patients taking statins. The causal relationship is not definitively established, but due to its serious nature, it is considered a potential side effect. Symptoms to watch for: Severe stomach pain may spread to your back and worsen after a meal. Seek immediate medical attention if these symptoms occur.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Crestor, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Crestor should not be used if you are:
• A woman of childbearing potential who is not using appropriate contraceptive measures.
• Have a known allergy or hypersensitivity to rosuvastatin or any ingredients in Crestor.
• Have active liver disease: This includes acute liver failure or persistent, unexplained elevations in liver enzymes (transaminases). Crestor can worsen liver problems.
• Pregnant or breastfeeding: Rosuvastatin can harm an unborn baby and is excreted in breast milk.

Tell your doctor about all of your medical conditions, past and present, before starting Crestor. This is crucial because certain conditions affect whether Crestor is right for you. These conditions may include, but are not limited to:
• Have predisposing factors for myopathy/rhabdomyolysis (especially at the 40 mg dose): Myopathy is muscle pain, tenderness, or weakness, and rhabdomyolysis is a serious breakdown of muscle tissue that can lead to kidney damage. Factors increasing this risk include:
o Alcohol abuse.
o Asian patients (they may have higher rosuvastatin plasma levels and thus a higher risk, often requiring a lower starting dose).
o Concomitant use of certain medications that increase the risk of muscle problems (e.g., cyclosporine, gemfibrozil, certain antiviral medications, high niacin, colchicine).
o Hypothyroidism (underactive thyroid) that is not well-managed.
o Personal or family history of hereditary muscular disorders.
o Previous history of muscular toxicity with another HMG-CoA reductase inhibitor (statin) or fibrate.
o Severe renal impairment (kidney problems, particularly creatinine clearance < 30 mL/min).
o Situations where rosuvastatin plasma levels may increase (e.g., certain drug interactions - see below).
• Myasthenia Gravis or Ocular Myasthenia: There have been post-marketing reports of new onset or exacerbation of myasthenia gravis or ocular myasthenia with statin use, including rosuvastatin. Patients with pre-existing or a history of myasthenia gravis or ocular myasthenia should use rosuvastatin with caution and be monitored for worsening symptoms.
• Unexplained persistent elevations in transaminases (liver enzymes).

Drug Interactions:

Before taking Crestor, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Details for rosuvastatin: https://dhpp.hpfb-dgpsa.ca/dhpp/resource/89622.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Crestor. Crestor may interact with other medicines, but is not limited to:
• Antacids containing aluminum and magnesium hydroxide can decrease Crestor's absorption, making it less effective.
• Certain antiviral medications (e.g., for HIV or Hepatitis C): Some combinations are not recommended, while others require careful dose adjustments of Crestor (e.g., 5 mg or 10 mg daily).
• Colchicine: Can increase the risk of myopathy.
• Cyclosporine: Concomitant use is generally not recommended, or the Crestor dose should not exceed 5 mg once daily.
• Darolutamide and Regorafenib: May significantly increase rosuvastatin exposure, requiring Crestor dose adjustments.
• Other lipid-lowering therapies:
o Fibrates (e.g., gemfibrozil, fenofibrate)
o High doses of niacin (nicotinic acid) (≥1 g/day)
• Warfarin (a blood thinner): Crestor can prolong INR (a measure of blood clotting time), requiring frequent monitoring when starting or changing Crestor therapy.

Pregnancy and Breastfeeding

Crestor can harm an unborn baby and is not recommended during pregnancy. It's also not recommended for breastfeeding mothers as the drug can pass into breast milk. Women of childbearing potential should use appropriate contraceptive measures.

Frequently Asked Questions about Crestor at Canada Pharmacy Online:

Why is Crestor more affordable in Canada than in the United States?

Prescription drug prices, including Crestor, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Crestor 10 mg and 20 mg?

The dosage difference represents the amounts of the same active ingredient (rosuvastatin) in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Crestor at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Crestor requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Crestor?

Yes, there is a generic alternative for this product called rosuvastatin.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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