Wellbutrin XL (Bupropion Hydrochloride 24H ER Tablet)

Name: Wellbutrin XL
Brand: Bausch Health
SKU: 6037
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Wellbutrin XL

Manufacturer: Bausch Health

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Wellbutrin XL

Manufacturer: Bausch Health

Country: Canada

Dosage: 300 mg

Qty-Price (USD):

Generic Equivalent of Wellbutrin XL

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Bupropion Hydrochloride 24H ER Tablet

Manufacturer: Generic

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Bupropion Hydrochloride 24H ER Tablet

Manufacturer: Generic

Country: Canada

Dosage: 300 mg

Qty-Price (USD):

Wellbutrin XL Information

medically reviewed by Carol Hou (BSc. Pharm) on July 2, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Wellbutrin XL and Bupropion Hydrochloride Extended-release at CanadaPharmacyOnline.com

Brand Wellbutrin XL is manufactured by Bausch Health and distributed in several countries globally, including Canada.

Generic bupropion hydrochloride extended-release is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Bupropion Hydrochloride Extended-release:

Generic bupropion hydrochloride extended-release contains the same active ingredient as brand-name Wellbutrin XL and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Wellbutrin XL. Studies have demonstrated bioequivalence between generic and brand-name bupropion hydrochloride extended-release, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have questions about using generic bupropion hydrochloride extended-release.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Brand Wellbutrin XL and generic bupropion hydrochloride extended-release are commonly available in 150 mg and 300 mg 24H extended-release tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Wellbutrin XL (bupropion hydrochloride extended-release tablets) is a prescription medication used to treat adults diagnosed with Major Depressive Disorder (MDD) and to prevent Seasonal Affective Disorder (SAD).

Mechanism of Action:
Wellbutrin XL (bupropion hydrochloride extended-release tablet) acts as a norepinephrine-dopamine reuptake inhibitor (NDRI) by inhibiting the reuptake of norepinephrine and dopamine in the brain. This action slows the removal of these neurotransmitters from the synaptic cleft, the space between nerve cells, resulting in increased concentrations. Bupropion's efficacy is associated with its ability to inhibit the reuptake of norepinephrine and dopamine, thereby increasing their synaptic concentrations. Increased dopamine levels influence the brain's reward pathways, motivation, and feelings of pleasure. Importantly, bupropion, the active ingredient, is metabolized into other active compounds, such as hydroxybupropion, which exhibit NDRI activity and contribute to the overall pharmacological effect. Wellbutrin XL has minimal direct impact on serotonin reuptake, which distinguishes it from many selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) and may contribute to its different side effect profile. While the precise neurobiological mechanisms underlying its antidepressant and SAD-preventing effects are complex and not fully elucidated, the dual inhibition of norepinephrine and dopamine reuptake is considered a primary mechanism by which Wellbutrin XL helps to alleviate symptoms of depression and prevent seasonal affective disorder.

Take Wellbutrin XL exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Wellbutrin XL, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Wellbutrin XL (bupropion hydrochloride extended-release tablets). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Wellbutrin XL, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.

The following side effects are mild and may disappear as your body adjusts to the medication.
• Abdominal pain
• Agitation
• Anxiety
• Changes in libido (most commonly decreased libido)
• Constipation
• Dizziness
• Dry mouth
• Headache
• Heart palpitations
• Hot flashes
• Increased sweating
• Loss of appetite
• Memory problems (Memory problems are a possible side effect of Wellbutrin XL. While not as typical as other listed side effects, individuals may still experience this. If you notice any changes in your memory, it's important to discuss them with your doctor.
• Muscle aches
• Nausea
• Ringing in the ears (tinnitus)
• Sore throat
• Tremor
• Trouble sleeping (insomnia)
• Weight loss or gain

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Cutaneous Lupus Erythematosus (CLE): This autoimmune reaction affects the skin, causing red, thick, scaly rashes that may burn or itch.
• High Blood Pressure (Hypertension): This can be severe in some cases and may present with headaches, increased heart rate, confusion, or chest pain.
• Manic Episodes: People with bipolar disorder may experience mania, with symptoms like increased energy, racing thoughts, reckless behavior, and extreme irritability.
• New or Worsening Mental Health Problems: This includes changes in behavior or thinking, aggression, hostility, agitation, depression, and suicidal thoughts or actions.
• Seizures: The risk is higher in people with a history of seizures or certain medical conditions. Symptoms can include fainting, uncontrollable movements, confusion, and stiffening of limbs.
• Serotonin Toxicity: While the risk of serotonin syndrome with bupropion used alone is generally considered low due to its primary action on norepinephrine and dopamine reuptake, its active metabolite, hydroxybupropion, has some weak serotonergic activity. However, significant serotonin syndrome is rare with bupropion monotherapy because its overall impact on serotonin is much less pronounced compared to medications that directly target serotonin reuptake. Caution is still advised when bupropion is combined with other medicines that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), as this can increase the risk of serotonin syndrome.
• Severe Allergic Reactions: Symptoms can include rash, itching, hives, fever, swollen lymph glands, painful sores, swelling of the face or tongue, chest pain, and difficulty breathing.
• Unusual Thoughts or Behaviors: This can include delusions, hallucinations, paranoia, and confusion.
• Visual Problems: Wellbutrin XL can increase the risk of angle-closure glaucoma, with symptoms like eye pain, blurred vision, halos around lights, and redness or swelling in the eye.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Wellbutrin XL, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Wellbutrin XL should not be used if:
• You are allergic to bupropion hydrochloride extended-release and inactive ingredients in this medication.
• You are currently taking or have recently taken a monoamine oxidase inhibitor (MAO) within the past 14 days, such as isocarboxazid, phenelzine, selegiline, or tranylcypromine: Combining these medications can lead to serious and potentially life-threatening side effects, including high blood pressure.
• You have a current or past diagnosis of an eating disorder, such as anorexia or bulimia: These conditions increase the risk of seizures.
• You have a seizure disorder: Wellbutrin XL can increase the risk of seizures.
• You have abruptly stopped drinking alcohol or taking certain medications known to lower the seizure threshold, including benzodiazepines, barbiturates, or antiepileptic drugs. This is because abrupt withdrawal from these substances can increase the risk of seizures, and Wellbutrin XL can further lower the seizure threshold.

Tell your doctor about all your medical conditions, past and present, before starting Wellbutrin XL. This is crucial because certain conditions affect whether Wellbutrin XL is right for you. These conditions may include, but are not limited to:
• Current or prior diagnosis of bulimia or anorexia nervosa: People with a history of these eating disorders have a higher risk of seizures when taking Wellbutrin XL.
• Diabetes: Changes in blood sugar levels have been reported in rare cases in individuals taking Wellbutrin XL. While clinical studies have not established a significant or consistent direct effect of bupropion on blood glucose regulation, any psychoactive medication can indirectly influence blood sugar control due to potential changes in appetite, activity levels, or stress response. Individuals with diabetes should continue to monitor their blood sugar levels closely as directed by their healthcare provider and inform their doctor of any significant changes observed after starting bupropion so that the potential cause can be evaluated.
• Eating disorders: Mention if you currently have or have ever had bulimia or anorexia nervosa.
• Glaucoma: Especially if you have angle-closure glaucoma.
• Head injuries or brain tumors: These can increase the risk of seizures.
• Heart problems: Discuss any history of heart disease, high blood pressure, or irregular heartbeats.
• Kidney or liver problems can affect how your body processes the medication.
• Mental health conditions: Inform your doctor about any current or past mental health conditions, including bipolar disorder, anxiety, depression (even if it's what you're seeking treatment for), or psychosis.
• Sleep problems: Mention any issues with insomnia or other sleep disorders.

Alcohol:
Combining bupropion hydrochloride extended-release with alcohol is generally not recommended. Alcohol can lower the seizure threshold, and this effect may be compounded by bupropion. There is also a potential for increased risk of psychiatric side effects, such as mood and behavioral changes. Furthermore, bupropion might affect alcohol tolerance in some individuals. Abrupt alcohol withdrawal in chronic users is a known risk factor for seizures, which can be further complicated by bupropion's effect on the seizure threshold.

Caffeine:
High doses of caffeine may have additive stimulant effects with bupropion and could potentially lower the seizure threshold in susceptible individuals. Significant and abrupt increases in caffeine intake may also exacerbate specific side effects, like anxiety, nervousness, and insomnia, in some individuals taking bupropion. It is advisable to maintain consistent and moderate caffeine intake while taking bupropion and discuss any significant changes in caffeine consumption with your doctor.

Driving or operating machinery:
Wellbutrin XL may impair your thinking and reactions. You should not drive, operate machinery, or do any activity that requires you to be alert until you know how it will affect you.

Smoking:
If you smoke, let your doctor know, as smoking can affect how your body processes certain medications.

Suicidal Thoughts and Behaviors:
Antidepressants can increase the risk of these, especially in children, adolescents, and young adults. It's crucial to monitor for any changes in mood or behavior.

Upcoming surgeries or medical procedures:
Inform your doctor if you have any scheduled surgeries or procedures.

Drug Interactions:

Before taking Wellbutrin XL, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Wellbutrin XL prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Wellbutrin XL. Wellbutrin XL may interact with other medicines, but is not limited to:

Major Interactions (Contraindicated Combinations): These combinations should be avoided due to the high risk of severe adverse effects. They include:
• Eliglustat: Bupropion can increase the levels of eliglustat, a medication for Gaucher disease, potentially leading to increased side effects.
• Monoamine Oxidase Inhibitors (MAOIs): Such as isocarboxazid, linezolid, methylene blue, phenelzine, rasagiline, safinamide, selegiline, and tranylcypromine. Combining bupropion with MAOIs can lead to a hypertensive crisis (dangerously high blood pressure), confusion, agitation, restlessness, stomach or bowel symptoms, sudden high body temperature, and severe convulsions. At least 14 days should elapse between discontinuing an MAOI and starting bupropion, and vice versa.
• Pimozide: Bupropion can increase the levels of pimozide, a medication used for specific psychiatric disorders, which can increase the risk of heart problems.

Serious Interactions (Avoid or Use Alternate Drug): These combinations can also lead to significant risks and should generally be avoided unless there are no suitable alternatives. They include:
• Antipsychotics: Combining bupropion with certain antipsychotics (such as haloperidol, risperidone, paliperidone, and thioridazine) can increase the risk of seizures due to the potential for both types of medications to lower the seizure threshold. Additionally, bupropion can inhibit the metabolism of some antipsychotics (e.g., those primarily metabolized by CYP2D6, such as risperidone and paliperidone), potentially leading to increased levels and side effects of the antipsychotic.
• Beta-blockers: These include metoprolol, propranolol, and timolol. Bupropion can inhibit CYP2D6, which metabolizes some beta-blockers, potentially leading to increased levels of the beta-blocker and a higher risk of its side effects, such as bradycardia and hypotension.
• Blood thinners: Such as ticlopidine and clopidogrel. Bupropion may increase the levels of these drugs.
• Certain antiarrhythmic drugs, Such as flecainide and propafenone. The risk of side effects from both bupropion and the antiarrhythmic drugs may be increased.
• Certain HIV drugs: Such as ritonavir, lopinavir, and efavirenz. These drugs can affect cytochrome P450 enzymes, including CYP2B6, which metabolizes bupropion. Inducers like efavirenz can lead to decreased levels of bupropion, potentially reducing its effectiveness.
• Digoxin: Bupropion can make digoxin less effective.
• Drugs that lower the seizure threshold: This includes other antidepressants, antipsychotics, stimulants (like amphetamine/dextroamphetamine, lisdexamfetamine), theophylline, and systemic corticosteroids. Using these with bupropion increases the risk of seizures.
• Levodopa and Amantadine: Combining with bupropion can increase the risk of side effects such as restlessness, agitation, tremors, dizziness, and balance problems.
• Other antidepressants: Combining bupropion with other antidepressants, such as SSRIs (e.g., fluoxetine, sertraline, paroxetine, citalopram, escitalopram), SNRIs (e.g., venlafaxine, duloxetine), and tricyclic antidepressants (e.g., clomipramine, amitriptyline), can increase the risk of side effects, particularly due to the potential for additive effects on lowering the seizure threshold. Additionally, bupropion can inhibit CYP2D6, which metabolizes many of these antidepressants (e.g., fluoxetine, paroxetine, sertraline, venlafaxine), potentially leading to increased levels and side effects of the co-administered antidepressant.
• St. John's Wort: May increase the risk of central nervous system side effects.
• Systemic corticosteroids: Such as prednisone and methylprednisolone. Use with bupropion may increase the risk of seizures.
• Tamoxifen: Bupropion can make tamoxifen less effective.
• Theophylline: Combining with bupropion can increase the risk of theophylline side effects, including seizures.

Moderate Interactions (Usually Avoid Combinations): These combinations may require dose adjustments or careful monitoring.
• Drugs metabolized by CYP2B6: Bupropion is metabolized by this enzyme, so other drugs affecting this enzyme (inhibitors or inducers) can alter bupropion levels. Examples include cyclophosphamide and orphenadrine. CYP2B6 inhibitors could increase bupropion levels, while CYP2B6 inducers (e.g., carbamazepine, phenobarbital) could decrease bupropion levels.
• Drugs metabolized by CYP2D6: Bupropion can inhibit this enzyme, potentially increasing the levels and effects of other drugs it metabolizes, such as certain antidepressants, antipsychotics, and beta-blockers.

Pregnancy or breastfeeding:

If you're pregnant, planning to become pregnant, or breastfeeding, it's important to talk with your doctor before starting or continuing Wellbutrin XL. They can help you understand the potential risks and benefits and determine the best course of action for your individual situation.

Frequently Asked Questions about Wellbutrin XL at Canada Pharmacy Online:

Why is Wellbutrin XL more affordable in Canada than in the United States?

Prescription drug prices, including Wellbutrin XL, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Wellbutrin XL 150 mg and 300 mg?

The difference in dosage represents the different amount of the same active ingredient (bupropion hydrochloride extended-release) present in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Wellbutrin XL at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Wellbutrin XL requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Wellbutrin XL?

Yes, there is a generic alternative for this product called bupropion hydrochloride extended-release.

Can the Wellbutrin XL tablet be split or crushed?

Wellbutrin XL tablets should be swallowed whole, not crushed, divided, or chewed. They are designed with a special extended-release mechanism to release the medication slowly and consistently over about 24 hours. Splitting the tablet will damage this mechanism. This can cause the entire dose of the medication to be released into your system all at once, which can increase the risk of serious side effects, including seizures.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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