Januvia (Sitagliptin)

Name: Januvia
Brand: Merck
SKU: 6397
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: India

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: Turkey

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Januvia Tablet

Manufacturer: Merck

Country: Australia

Dosage: 100 mg

Qty-Price (USD):

Generic Equivalent of Januvia

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Sitagliptin Tablet

Manufacturer: Generic

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Sitagliptin Tablet

Manufacturer: Generic

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Sitagliptin Tablet

Manufacturer: Generic

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Sitagliptin Tablet

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Sitagliptin Tablet

Manufacturer: Generic

Country: India

Dosage: 100 mg

Qty-Price (USD):

Januvia Information

medically reviewed by Carol Hou (BSc. Pharm) on October 8, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Januvia and Sitagliptin at CanadaPharmacyOnline.com

The brand Januvia, manufactured by Merck, is available in numerous countries globally, including Canada, India, Turkey, and Australia.

Generic sitagliptin is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Sitagliptin:

Generic sitagliptin contains the same active ingredient as brand-name Januvia and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Januvia. Studies have shown that generic sitagliptin is bioequivalent to the brand-name Januvia, meaning it has similar absorption rates and reaches similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

The brand Januvia and its generic equivalent, sitagliptin, are commonly available in strengths of 25 mg, 50 mg, and 100 mg oral tablets.

Your conditions will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Januvia (sitagliptin) is a prescription medication designed to help manage type 2 diabetes in adults. This medication is used alone or in combination with other diabetes medications. When combined with a healthy diet and regular exercise, it helps improve blood sugar control. It's important to note that Januvia is specifically for type 2 diabetes and is not used to treat type 1 diabetes.

Mechanism of Action:
Januvia works by inhibiting DPP-4 (Dipeptidyl Peptidase-4), an enzyme that breaks down incretin hormones, such as GLP-1 (Glucagon-Like Peptide 1) and GIP (Gastric Inhibitory Polypeptide).

Usually, these hormones, which encourage the pancreas to release insulin when blood sugar is high and, specifically, GLP-1, reduce glucagon secretion, which leads to decreased sugar production by the liver, are quickly broken down by an enzyme called DPP-4. Januvia acts as a "DPP-4 inhibitor", blocking this enzyme and allowing incretin hormones to stay active longer in the body. This leads to more effective blood sugar control by increasing insulin release when needed and decreasing excess sugar from the liver, ultimately helping to lower both fasting and postprandial blood sugar levels in a manner that is dependent on your blood sugar being high, thereby reducing the risk of hypoglycemia.

Take Januvia exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Januvia, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Januvia (sitagliptin). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are some common side effects of Januvia; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Headache
• Low blood sugar (hypoglycemia)
• Nasal congestion
• Sore throat
• Upper respiratory tract infection
• Vomiting

Other Potential Side Effects (less common):
• Constipation
• Diarrhea
• Stomach pain

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any signs of an allergic reaction, such as:
• Allergic reactions
• Bullous pemphigoid (a severe blistering skin condition)
• Heart failure
• Kidney problems or kidney failure
• Pancreatitis
• Severe and disabling joint pain

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Januvia, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Januvia should not be used if you have any of the following conditions:
• A severe hypersensitivity reaction to sitagliptin or any of its ingredients, such as anaphylaxis (severe allergic reaction with symptoms like difficulty breathing or swelling of the face/throat) or angioedema (swelling under the skin, especially of the face, lips, tongue, or throat).
• Diabetic ketoacidosis (a serious complication of diabetes).
• Type 1 diabetes mellitus.

Tell your doctor about your medical conditions, past and present, before starting Januvia. This is crucial because certain conditions can affect whether Januvia is right for you. These conditions may include, but are not limited to:
• Heart failure: While not a contraindication, there have been post-marketing reports of heart failure with some DPP-4 inhibitors (the class Januvia belongs to). Your doctor will weigh the risks and benefits if you have a history of heart failure.
• History of pancreatitis: It is unknown if having had pancreatitis increases the risk of getting it again while taking Januvia.
• Kidney problems (renal impairment): Dosage adjustments are necessary for patients with moderate to severe kidney impairment or end-stage renal disease (ESRD). Your doctor will assess your kidney function before and periodically during treatment.

Drug Interactions:

Before taking Januvia, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Januvia prescribing information | Merck.ca at https://www.merck.ca/en/wp-content/uploads/sites/20/2021/04/JANUVIA-CI_E.pdf.

Provide your doctor with a complete list of all your medications, including over-the-counter (OTC) drugs, vitamins, and herbal supplements. Januvia may interact with other medicines, but is not limited to:
• Alcohol: While Januvia is not known to interact with alcohol directly, alcohol consumption can affect blood sugar levels in people with diabetes. Therefore, it's generally advisable to limit alcohol intake as it can make blood sugar management more challenging.
• Digoxin: When Januvia (sitagliptin) is co-administered with digoxin (a medication used for heart conditions), there have been reports of a slight increase in digoxin's concentration in the blood. While this increase is generally not considered clinically significant, close monitoring of digoxin levels may be prudent in some patients to prevent potential toxicity.
• Herbal Remedies and Supplements: There is limited specific information on interactions between Januvia and many herbal remedies or supplements. However, some herbal products (e.g., Bitter Melon, Cinnamon) are also known to affect blood sugar levels, and their co-administration with Januvia could increase the risk of hypoglycemia. Always inform your doctor about any herbal remedies or supplements you are taking.
• Insulin and Insulin Secretagogues (e.g., Sulfonylureas, Meglitinides): When Januvia is used in combination with insulin or insulin secretagogues (like glimepiride, glipizide, glyburide, nateglinide, repaglinide), there is an increased risk of hypoglycemia (low blood sugar). This is because both types of medications lower blood sugar. Your doctor may need to lower the dose of your insulin or insulin secretagogue when starting Januvia to reduce this risk.
• Other Antidiabetic Agents: While Januvia is often used in combination with other oral antidiabetic agents (such as metformin or thiazolidinediones), these combinations are generally well-tolerated. However, careful monitoring of blood glucose levels is always essential when combining different diabetes medications to ensure optimal control and minimize risks.
• P-glycoprotein inhibitors/inducers: Sitagliptin is a substrate for P-glycoprotein (P-gp), a transporter protein. Therefore, medications that inhibit or induce P-gp could theoretically alter the absorption or elimination of sitagliptin. However, this interaction is generally not considered clinically significant enough to warrant routine dose adjustments. Examples of such drugs might include cyclosporine (a P-gp inhibitor).

Pregnancy and Breastfeeding:

Januvia is generally not advised for use during pregnancy or while breastfeeding. If you're pregnant, planning to conceive, or currently breastfeeding, it's crucial to consult your doctor immediately.

Frequently Asked Questions about Januvia at Canada Pharmacy Online:

Why is Januvia more affordable in Canada than in the United States?

Prescription drug prices, including Januvia, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784 for more information or to learn about the ordering process. Visit our How to Order page for details.

Is there a limit on the number of Januvia tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Januvia at one time, as per your doctor's prescription.

Can I buy Januvia over the counter from you?

No, Januvia requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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