Zetia (Ezetimibe)

Name: Zetia
Brand: Merck
SKU: 2390
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zetia

Manufacturer: Merck

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Zetia

Manufacturer: Merck

Country: Turkey

Dosage: 10 mg

Qty-Price (USD):

Generic Equivalent of Zetia

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Ezetimibe

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Ezetimibe

Manufacturer: Generic

Country: India

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Ezetimibe

Manufacturer: Generic

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Zetia Information

medically reviewed by Carol Hou (BSc. Pharm) on October 30, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Zetia and Ezetimibe at CanadaPharmacyOnline.com

Brand Zetia is manufactured by Merck in Canada and Turkey. It is also known as Ezetrol.

Generic ezetimibe is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Ezetimibe:

Generic ezetimibe contains the same active ingredients as brand-name Zetia and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in a similar way to Zetia. Studies have shown that generic ezetimibe is bioequivalent to brand-name Zetia, meaning it has a similar absorption rate and reaches identical concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Zetia and generic Ezetimibe are available as an oral tablet in a single strength of 10 mg.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Zetia is a prescription medication used to lower high levels of "bad" cholesterol (LDL-C) in the blood by inhibiting selective cholesterol absorption. It is most often prescribed alongside a healthy diet. It is frequently combined with a statin (another type of cholesterol-lowering medication) for patients who need extra help lowering their cholesterol levels or who cannot tolerate higher statin doses. It is also an option for certain inherited conditions that cause extremely high cholesterol or accumulation of plant-based fats in the body, such as homozygous familial hypercholesterolemia (HoFH) and homozygous sitosterolemia.

Mechanism of Action:
Zetia (ezetimibe) works by blocking the Niemann-Pick C1-Like 1 (NPC1L1) protein, which is found on the lining of the small intestine. By inhibiting this protein, Zetia acts as a barrier, preventing cholesterol—whether from food or bile—from being absorbed into the bloodstream. When less cholesterol reaches the liver from the gut, the liver is prompted to remove more cholesterol from circulation, effectively lowering LDL ("bad") cholesterol levels.

Take Zetia exactly as prescribed by your doctor, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Zetia, it is essential to discuss all possible effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Zetia (ezetimibe). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are some common side effects of Zetia; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Arthralgia (joint pain)
• Diarrhea
• Fatigue (feeling tired)
• Influenza (flu-like symptoms)
• Pain in extremity (pain in arms or legs)
• Sinusitis
• Upper respiratory tract infection (e.g., common cold, runny nose, sore throat)

Other Potential Side Effects (less common):
• Abdominal pain
• Back pain
• Cough
• Dizziness
• Headache
• Muscle pain (Myalgia)
• Nausea

Serious or rare side effects: These are rare but potentially severe. Seek immediate medical attention or call emergency services if you experience any signs of an allergic reaction, such as:
• Allergic reaction (symptoms can include swelling of the face, tongue, or throat, or a severe rash)
• Myopathy/Rhabdomyolysis (severe muscle breakdown indicated by unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or unusual tiredness)
• Hepatitis/Liver damage (may be indicated by unexplained increased liver enzymes, dark urine, pale stools, or yellowing of the skin or eyes)
• Pancreatitis (inflammation of the pancreas, which can cause severe abdominal pain)

Contraindications:

The following is not an exhaustive list of contraindications. Before taking Zetia, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Zetia should not be used under the following conditions:
• An active liver disease or unexplained, persistent elevation of liver enzymes (hepatic transaminases).
• A medical condition for which the statin or fenofibrate itself is specifically contraindicated.
• Known hypersensitivity to ezetimibe or any component of the formulation.

Tell your doctor about any medical conditions you have, past and present, before starting Zetia. This is important because certain conditions might influence whether Zetia is suitable for you. These conditions may include, but are not limited to:
• Hepatic impairment (moderate to severe liver disease)
• Myopathy (pre-existing muscle disorder)
• Pregnant or planning to become pregnant
• Severe renal impairment (severe kidney disease)

Drug Interactions:

Before taking Zetia, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Drug Label Information for Zetia – DailyMed.com at https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=174e45e0-45bb-48b7-9e60-8f6cfc1d22bb.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter drugs, vitamins, and herbal supplements. Zetia may interact with the following:
• Bile Acid Sequestrants (e.g., Cholestyramine, Colestipol): Can significantly decrease the concentration and effectiveness of Zetia.
• Cyclosporine (an immunosuppressant): Increases the level of total ezetimibe in the body, in some cases significantly (up to 12-fold was observed in one study). It may also increase cyclosporine levels.
• Fibrates (e.g., Fenofibrate, Gemfibrozil): Can increase the amount of ezetimibe in the body and may increase the risk of gallstones (cholelithiasis)
• Warfarin and other Coumarin Anticoagulants: Taking Zetia with these blood thinners has been reported to cause an increase in the International Normalized Ratio (INR), which indicates that the blood is thinning too much and may increase the risk of bleeding.

Pregnancy and Breastfeeding

Zetia (ezetimibe) is generally not recommended for use during pregnancy or breastfeeding because there is not enough human data to confirm its safety for the baby. If you are taking Zetia alone, your doctor will likely advise you to stop taking it or switch to a different, safer cholesterol medication, such as a bile acid sequestrant. This caution is even stronger if you take Zetia with a statin, as all statin therapy is routinely contraindicated during both pregnancy and breastfeeding. It's essential to speak with your healthcare provider immediately if you become pregnant or are planning to conceive, so they can adjust your treatment to ensure the safety of both you and your baby.

Use in Children:

Zetia (ezetimibe) is generally safe for use in children 10 years and older who have high cholesterol or a severe inherited condition called Familial Hypercholesterolemia (HeFH/HoFH). For a rarer genetic fat disorder called Homozygous Sitosterolemia, it is approved for children as young as 9 years old. When treating high cholesterol, Zetia is often used in combination with another medication called a statin.

Frequently Asked Questions about Zetia at Canada Pharmacy Online:

Why is Zetia more affordable in Canada than in the United States?

Prescription drug prices, including Zetia, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784 for more information or to learn about the ordering process. Visit our How to Order page for details.

Can I buy Zetia over the counter from you?

No, Zetia requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Is Zetia a statin?

Zetia (Ezetimibe) belongs to a group of cholesterol absorption inhibitors (or cholesterol-lowering drugs). Lipitor belongs to a different class of medicines called statins, which act by preventing the production of cholesterol.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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