Topamax (Topiramate)

Name: Topamax
Brand: Janssen-Cilag
SKU: 2123
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Topamax

Manufacturer: Janssen-Cilag

Country: India

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen-Cilag

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Topamax (ON BACKORDER)

Manufacturer: Johnson & Johnson

Country: Turkey

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen-Cilag

Country: India

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen-Cilag

Country: Australia

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topamax (ON BACKORDER)

Manufacturer: Janssen-Cilag

Country: Turkey

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topamax (EXPIRY 07/25)

Manufacturer: Janssen-Cilag

Country: Australia

Dosage: 200 mg

Qty-Price (USD):

Type:

Product: Topamax

Manufacturer: Janssen

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Generic Equivalent of Topamax

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Topiramate

Manufacturer: Generic

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: India

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: United Kingdom

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Topiramate

Manufacturer: Generic

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Topamax Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on July 17, 2025.

Topamax and Topiramate at CanadaPharmacyOnline

Janssen Inc. manufactures Topamax (topiramate) in Canada and other countries, including Australia, India, and Turkey.

Generic topiramate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Topiramate

Generic topiramate contains the same active ingredient as brand-name Topamax and is required to meet the same safety, effectiveness, and quality standards. This means it's designed to work in the same way as Topamax. Studies have demonstrated bioequivalence between generic and brand-name topiramate, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about using generic topiramate.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Both brand-name Topamax and its generic version, topiramate, are available as oral tablets in various strengths, commonly including 25 mg, 50 mg, 100 mg, and 200 mg.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage

Topiramate is a prescription medication used to treat epilepsy by preventing and managing seizures in adults and children (as monotherapy or adjunctive therapy for partial-onset seizures, primary generalized tonic-clonic seizures, and seizures associated with Lennox-Gastaut Syndrome). It is also used to prevent migraine headaches in adults and adolescents aged 12 years and older.

Mechanism of Action
Topamax (topiramate) is an anticonvulsant that works through multiple proposed mechanisms to stabilize nerve activity in the brain. Its primary actions are believed to include:
• Blocking voltage-dependent sodium channels: This limits the rapid firing of nerve impulses.
• Enhancing gamma-aminobutyric acid (GABA) activity: GABA is an inhibitory neurotransmitter, and increasing its effects helps calm overactive nerve cells.
• Blocking AMPA/kainate glutamate receptors: Glutamate is an excitatory neurotransmitter, and blocking its effects reduces excessive nerve signaling.
• Weak inhibition of carbonic anhydrase: While weak, this action can contribute to some of its effects, including metabolic acidosis.
By these combined actions, topiramate helps to calm overactive nerve cells, preventing the excessive electrical signals that can lead to seizures or migraine episodes.

Use Topamax exactly as prescribed by your doctor. Please do not change your dosage or stop the medication without first consulting your doctor. Follow the instructions in the patient information leaflet.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Topamax, it's essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Topamax, it's crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – The following are examples of some common side effects of Topamax; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain
• Anorexia (loss of appetite)
• Constipation
• Diarrhea
• Dizziness
• Difficulty with memory or concentration ("brain fog")
• Drowsiness/sleepiness
• Fatigue (low energy)
• Impaired taste (changes in how things taste)
• Nausea
• Nervousness
• Paresthesia (tingling, numbness in arms and legs)
• Speech problems (e.g., difficulty finding words, slowed speech)
• Weight loss

Serious or rare side effects – Stop taking Topamax and seek immediate medical attention right away if you experience any of the following symptoms:
• Acute myopia and secondary angle closure glaucoma (sudden decrease in vision, eye pain, redness, or blurred vision; can lead to permanent visual loss)
• Allergic reaction (e.g., rash, hives, swelling of face, lips, tongue, throat, difficulty breathing or swallowing)
• Decreased sweating and increased body temperature (especially in children and during hot weather)
• Depression or suicidal thoughts/behaviour (new or worsening mood changes, thoughts of self-harm)
• Kidney stones (e.g., sudden severe back or side pain, blood in urine, painful or frequent urination)
• Metabolic acidosis (high level of acid in the blood; symptoms include rapid breathing, fatigue, confusion, and heart palpitations)
• High ammonia levels in blood (hyperammonemia) with or without encephalopathy (e.g., unexplained lethargy, vomiting, mental changes like confusion) • New or worsening seizures • Severe skin reactions (e.g., severe rash with or without peeling, blistering, skin discoloration, hives)

Contraindications

This isn't an exhaustive list of contraindications. It's crucial to discuss all your medical conditions, past and present, and all medications you're taking with your doctor or pharmacist before starting Topamax.

Topamax shouldn't be used if:
• You're allergic to topiramate or any of its ingredients.
• You have metabolic acidosis that needs medical treatment.
• You have acute porphyria, a specific blood disorder.

Tell your doctor about all of your medical conditions, past and present, before starting Topamax. This is crucial because certain conditions can affect whether Topamax is right for you. These conditions may include, but aren't limited to:
• Bone problems (e.g., osteoporosis)
• Depression or a history of mood disorders
• Diabetes or high blood sugar
• Eye problems (especially glaucoma)
• History of kidney stones or kidney disease
• History of liver problems
• History of ketogenic diet or plan to start one
• Lung disease
• Metabolic acidosis
• Suicidal thoughts or attempts

Dizziness and Drowsiness
Topamax commonly causes dizziness, drowsiness, and slowed thinking. Avoid driving, operating machinery, or engaging in activities that require mental alertness until you understand how it affects you. Be cautious when standing up quickly, especially if you are an older patient, to reduce the risk of dizzy or fainting spells.

Pregnancy and Breastfeeding

Tell your doctor if you're pregnant or planning to become pregnant. Topiramate can cause serious harm to an unborn baby, including birth defects (especially cleft lip and/or palate) and slowed growth. Women of childbearing potential should use effective contraception during treatment. It's crucial to discuss the risks versus benefits with your doctor if you are pregnant or planning to become pregnant. Topiramate passes into breast milk and may harm a nursing infant. Breastfeeding isn't recommended while taking Topamax. Women who are breastfeeding should discuss the risks and benefits with their doctor.

Use in Older Adults

Older adults may be more susceptible to specific side effects, such as dizziness, cognitive impairment, or bone problems. Dosage adjustments and careful monitoring may be necessary, particularly in older patients with kidney impairment.

Drug Interactions

Before taking Topamax, it's essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Prescribing Information | Janssen.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Topamax can interact with several medications, including (but not limited to):
• Alcohol: Can significantly increase dizziness, drowsiness, confusion, and difficulty speaking.
• Antacids (e.g., containing magnesium or aluminum hydroxide) May affect the absorption of topiramate.
• Antidepressants (e.g., amitriptyline, SSRIs like fluoxetine, sertraline, escitalopram, and bupropion) May increase the risk of side effects or seizures. • Antihistamines (sedating, e.g., diphenhydramine, hydroxyzine): Can increase drowsiness.
• Antipsychotics (e.g., risperidone)
• Carbonic Anhydrase Inhibitors (e.g., acetazolamide, zonisamide): Increased risk of kidney stones and metabolic acidosis.
• Central Nervous System (CNS) Depressants (e.g., sedatives, tranquillizers, opioid pain medications, other anticonvulsants) Can increase drowsiness and other central nervous system (CNS) side effects.
• Diabetes Medications (e.g., metformin, glyburide, pioglitazone) May increase the risk of metabolic acidosis or reduce the effectiveness of diabetes drugs.
• Digoxin: May decrease digoxin levels.
• Hormonal Contraceptives (birth control pills containing estrogen): Topamax can make hormonal birth control less effective, leading to an unexpected pregnancy. Non-hormonal contraception should be considered, or your doctor may adjust your contraceptive method.
• Hydrochlorothiazide (HCTZ): May increase topiramate blood levels.
• Lithium: This may increase lithium levels and toxicity.
• Phenytoin, Carbamazepine, Phenobarbital, Valproic Acid (Valproate/Divalproex): These other anti-epileptic drugs can affect topiramate levels or increase the risk of specific side effects (e.g., hyperammonemia with valproic acid).
• St. John's Wort: Can decrease topiramate levels, reducing its effectiveness.
• Vitamin C and Calcium supplements (high doses) May increase the risk of kidney stones.

Frequently Asked Questions about Topamax at Canada Pharmacy Online

Why is Topamax more affordable in Canada than in the United States?

Prescription drug prices, including Topamax, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I take Topamax with food?

Topamax can be taken with or without food. However, if it upsets your stomach, taking it with food may help alleviate the discomfort.

Can I crush or chew Topamax tablets?

Topamax tablets should be swallowed whole. Do not crush, chew, or break them, as they have a bitter taste. If you're prescribed Topamax sprinkle capsules, you can open them and sprinkle the entire contents on a small amount of soft food (like applesauce), then swallow immediately without chewing.

Will Topamax cure my epilepsy or migraines?

Topamax helps to control seizures and prevent migraine headaches. It is not a cure for epilepsy or migraines and will only work to manage symptoms as long as you continue to take it.

How quickly does Topamax start working?

It takes time for Topamax to reach effective levels in your body due to the gradual dosing schedule. You may start to notice some effects within a few weeks. However, the full therapeutic benefits for seizure control or migraine prevention may take several weeks to months to become apparent.

What should I do if I miss a dose of Topamax?

If you miss a dose of Topamax, take it as soon as you can unless it is within 6 hours of your next scheduled dose. If it is within 6 hours of your next dose, skip the missed dose and take your next dose at the expected time. Do not take a double or extra dose.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Blog Posts:

Suffering From Migraines? Make Sure You’re Not Deficient in This Important Mineral

Latest News:

Epilepsy and Sleep: Understanding the Relationship (article published on July 15, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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