Trintellix (Vortioxetine)

Name: Trintellix
Brand: Lundbeck
SKU: 7365
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Turkey

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Australia

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: United Kingdom

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Australia

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Trintellix (ON BACKORDER)

Manufacturer: Lundbeck

Country: Turkey

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Trintellix

Manufacturer: Lundbeck

Country: Australia

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Trintellix (ON BACKORDER)

Manufacturer: Lundbeck

Country: Turkey

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Trintellix (ON BACKORDER)

Manufacturer: Lundbeck

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Generic Equivalent of Trintellix

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Vortioxetine

Manufacturer: Generic

Country: India

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Vortioxetine

Manufacturer: Generic

Country: India

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Vortioxetine

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Trintellix Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on October 17, 2025.

Trintellix and Vortioxetine at CanadaPharmacyOnline.com

Vortioxetine, a product from Lundbeck, is known by two different brand names globally. It is marketed as Trintellix in the U.S. and Canada, and as Brintellix in most other international markets, including Australia, Turkey (known as Fonksera), and the United Kingdom.

Generic vortioxetine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Vortioxetine:

Generic vortioxetine contains the same active ingredients as brand-name Trintellix and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in a similar way to Trintellix. Studies have shown that generic vortioxetine is bioequivalent to brand-name Trintellix, meaning it has a similar absorption rate and reaches identical concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs.

Dosage:

The brand Trintellix and its generic equivalent, vortioxetine, are available as immediate-release tablets in the primary strengths of 5 mg, 10 mg, and 20 mg.

Your conditions will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Trintellix is a prescription medication used in adults for the treatment of Major Depressive Disorder (MDD). It also helps prevent the symptoms of depression.

Mechanism of Action:
Trintellix (vortioxetine) belongs to a class of medications known as atypical antidepressants or, more specifically, a serotonin modulator and stimulator (SMS). It functions as a multimodal antidepressant, meaning it works in a complex way in the brain by performing two main actions: it increases serotonin levels by blocking its reuptake, similar to other common antidepressants, and it also directly influences the activity of several serotonin receptors. This unique combination is believed not only to relieve multiple symptoms of depression but also to help prevent symptoms from returning over the long term.

Take Trintellix exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information summarizes some, but not all, potential side effects, risks, and interactions. Before taking Trintellix, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Trintellix (vortioxetine). It is not an exhaustive list, and individual reactions can vary.

Common side effects – The following are common side effects of Trintellix; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Constipation
• Diarrhea
• Dizziness
• Nausea
• Sexual dysfunction (e.g., decreased sex drive, ejaculation disorder)
• Vomiting

Other Potential Side Effects (less common):
• Abnormal dreams
• Dry mouth
• Headache
• Itching (pruritus)
• Insomnia (trouble sleeping)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any signs of an allergic reaction, such as:
• Activation of Mania or Hypomania: Extreme increase in energy, reckless behavior, or racing thoughts.
• Angle-Closure Glaucoma: Eye pain, vision changes, or swelling/redness around the eye.
• Increased Risk of Bleeding: Unusual bruising, nosebleeds, or internal bleeding (e.g., black or bloody stools).
• Low Sodium Levels (Hyponatremia): Confusion, difficulty concentrating, headache, or unsteadiness
• Severe Allergic Reactions (Hypersensitivity): Swelling of the face, tongue, or throat; difficulty breathing; or severe rash.
• Serotonin Syndrome: Agitation, confusion, fast heart rate, fever, hallucinations, or severe muscle stiffness/twitching.
• Suicidal Thoughts or Behaviors: Worsening depression, thoughts of self-harm, or sudden changes in behavior (especially in young adults).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Trintellix, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Trintellix should not be used under the following conditions:
• A known allergy to vortioxetine or any component of the formulation.
• You are currently being treated with the antibiotic linezolid or intravenous methylene blue.
• Monoamine Oxidase Inhibitor (MAOI) Use (Risk of Serotonin Syndrome):
o Current Use: Do not use Trintellix concomitantly with a psychiatric MAOI.
o Switching from MAOI to Trintellix: Do not start Trintellix until at least 14 days have passed after stopping a psychiatric MAOI.
o Switching from Trintellix to MAOI: Do not start a psychiatric MAOI until at least 21 days have passed after stopping Trintellix.

Tell your doctor about any medical conditions you have, past and present, before starting Trintellix. This is important because certain conditions might influence whether Trintellix is suitable for you. These conditions may include, but are not limited to:
• Activation of mania or hypomania (history or family history of bipolar disorder)
• Angle-closure glaucoma (or have anatomically narrow angles)
• Bleeding disorders or conditions that increase bleeding risk (especially if taking anticoagulants or NSAIDs)
• Hyponatremia (low sodium in the blood)
• Severe liver impairment
• Seizures or unstable epilepsy
• Suicidal thoughts or self-harm (history of or current significant ideation)

Drug Interactions:

Before taking Trintellix, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the Trintellix prescribing information | Takeda.com at https://content.takeda.com/?contenttype=PI&product=TRI&language=ENG&country=GBL&documentnumber=1.

Provide your doctor with a complete list of all your medications, including over-the-counter (OTC) drugs, vitamins, and herbal supplements. Trintellix may interact with other medicines, but is not limited to:
• Amphetamines (e.g., used for ADHD)
• Anticoagulants (e.g., Warfarin) and Antiplatelet Drugs (e.g., Clopidogrel): Trintellix can interfere with platelet function, and combining it with these drugs significantly increases the risk of bleeding (including gastrointestinal bleeding)
• Aspirin and NSAIDs (e.g., Ibuprofen, Naproxen): This also increases the risk of bleeding.
• Buspirone (Anti-anxiety medication)
• Diuretics (Water Pills): Concomitant use may increase the risk of developing hyponatremia (low sodium in the blood), especially in the elderly.
• Fentanyl (Opioid analgesic)
• Lithium (Mood stabilizer)
• Other Serotonergic Antidepressants (e.g., SSRIs, SNRIs, Tricyclic Antidepressants)
• Pain Medications (Certain opioids like Tramadol and Meperidine)
• St. John's Wort (Herbal supplement)
• Strong CYP Inducers (e.g., Carbamazepine, Phenytoin, Rifampin): These drugs speed up the breakdown of Trintellix, potentially decreasing its effectiveness.
• Strong CYP2D6 Inhibitors (e.g., Bupropion, Fluoxetine, Paroxetine, Quinidine): These drugs slow down the breakdown of Trintellix, causing its levels to build up and increasing the risk of side effects.
• Triptans (For migraines, e.g., Sumatriptan)
• Tryptophan (Supplement)

Use in Children:

Trintellix (vortioxetine) is approved for use only in adults and is not recommended for children and adolescents due to a potential increase in the risk of suicidal thoughts and actions in those under the age of 24 and younger.

Pregnancy and Breastfeeding:

Trintellix, especially in the last trimester, may pose risks to the newborn. Potential concerns include the baby experiencing short-term withdrawal symptoms (such as jitteriness, breathing problems, or constant crying) after birth, and a small, but rare, increased risk of a serious lung condition called persistent pulmonary hypertension of the newborn (PPHN). Limited data indicate that only a tiny amount of Trintellix passes into human breast milk. However, because the long-term effects on a breastfeeding infant are not fully understood, it is generally recommended to closely monitor the baby for signs of side effects, such as increased sleepiness, poor feeding, or changes in weight gain. If you are pregnant, planning to become pregnant, or breastfeeding, do not stop the medication suddenly without talking to your doctor, as this could cause a relapse of your depression.

Frequently Asked Questions about Trintellix at Canada Pharmacy Online:

Why is Trintellix more affordable in Canada than in the United States?

Prescription drug prices, including Trintellix, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784 for more information or to learn about the ordering process. Visit our How to Order page for details.

How long does it take for Trintellix to work?

Trintellix, like most antidepressants, doesn’t work immediately. It may take two weeks to notice the effects and four weeks to feel the full impact.

Can I buy Trintellix over the counter from you?

No, Trintellix requires a prescription from your doctor. We are unable to sell this product without a valid prescription from your doctor.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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