Prozac (Fluoxetine)

Name: Prozac
Brand: Eli Lilly
SKU: 1926
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Prozac Capsule (Discontinued)

Manufacturer: Eli Lilly

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Prozac Capsule (Discontinued)

Manufacturer: Eli Lilly

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Prozac Capsule (ON BACKORDER)

Manufacturer: Eli Lilly

Country: Australia

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Prozac Capsule (ON BACKORDER)

Manufacturer: Eli Lilly

Country: Turkey

Dosage: 20 mg

Qty-Price (USD):

Generic Equivalent of Prozac

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: India

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: India

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: United States

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Fluoxetine Capsule

Manufacturer: Generic

Country: India

Dosage: 60 mg

Qty-Price (USD):

Prozac Information

medically reviewed by Carol Hou (BSc. Pharm) on July 2, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Prozac and Fluoxetine at CanadaPharmacyOnline.com

The brand-name Prozac (fluoxetine) is manufactured by Eli Lilly and is available in various countries worldwide, including Australia and Turkey.

Generic fluoxetine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Fluoxetine:

Generic fluoxetine contains the same active ingredient as brand-name Prozac and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Prozac. Studies have shown that generic fluoxetine is bioequivalent to brand-name Prozac, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

The brand Prozac and generic fluoxetine are commonly available in 10 mg and 20 mg oral capsules (at this pharmacy).

The generic fluoxetine is available in 40 mg and 60 mg oral capsules.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) primarily prescribed to treat mental health conditions by increasing serotonin levels in the brain. Its main uses include major depressive disorder, obsessive-compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder (PMDD). It can also be used in combination with olanzapine for bipolar I disorder and treatment-resistant depression. Prozac is a prescription medication, and its full effects may take several weeks to become apparent.

Mechanism of Action
Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) that primarily blocks the reabsorption of serotonin into presynaptic neurons in the brain. This inhibition of the serotonin transporter protein leads to an increased concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. While the immediate effect is increased serotonin availability, the full therapeutic benefits, such as mood elevation and anxiety reduction, typically develop over several weeks. This suggests that downstream adaptive changes in neural circuits also contribute to its antidepressant and anxiolytic effects.

Take Prozac exactly as your doctor prescribes, following the instructions in the official Prozac product monograph. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Prozac, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Prozac (fluoxetine). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Prozac, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.

Very Common Side Effects ((affecting >10% of people)):
• Diarrhea: Drink plenty of fluids.
• Headache: Usually improves over time. If persistent or severe, consult your doctor.
• Insomnia (sleep problems): Often recommended to take in the morning.
• Nausea: Try taking it with or after food.

Common Side Effects (affecting 1%−10% of people):
• Abnormal dreams
• Anxiety and nervousness
• Dizziness
• Dry mouth
• Drowsiness/fatigue/weakness
• Flu-like symptoms (e.g., general aches, malaise)
• Increased sweating/hot flashes
• Loss of appetite and potential weight loss
• Rash/itching
• Sexual side effects:
o Decreased sex drive (libido)
o Difficulty achieving orgasm (anorgasmia)
o Erectile dysfunction (in men)
o Delayed or absent ejaculation (in men)
• Tremor or shaking
• Yawning

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Abnormal bleeding or bruising: Including nosebleeds, blood in vomit, and black or red stool.
• Angle-closure glaucoma: Fluoxetine can precipitate an acute angle-closure glaucoma attack, particularly in individuals anatomically predisposed to the condition. This risk is related to the drug's potential anticholinergic effects, which can cause pupillary dilation. Symptoms include sudden, severe eye pain, blurred vision, seeing colored rings around lights, and swelling or redness in or around the eye. Seek immediate medical attention if these symptoms occur. • Heart rhythm problems (QT prolongation): Dizziness, fainting, irregular heartbeat.
• Low sodium levels (hyponatremia): Headache, confusion, slurred speech, severe weakness, memory problems, feeling unsteady, seizures.
• Mania or Hypomania: Greatly increased energy, extreme irritability, racing thoughts, severe trouble sleeping, reckless behavior.
• Painful or prolonged erections (priapism): Lasting longer than 4 hours (seek immediate medical attention)
• Seizures.
• Serotonin Syndrome: A potentially life-threatening condition where too much serotonin builds up in the body. Symptoms include:
o Agitation, restlessness, confusion
o Fast heart rate
o Fever
o Hallucinations
o Nausea, vomiting, diarrhea
o Overactive reflexes
o Severe muscle stiffness or twitching
• Severe allergic reaction (anaphylaxis): Hives, difficulty breathing, swelling of the face, lips, tongue, or throat.
• Worsening depression or suicidal thoughts/behavior: This is particularly a risk in children, teenagers, and young adults (up to 24 years of age), especially at the beginning of treatment or with dose changes.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Prozac, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Prozac should not be used if you:
• Have a known allergy to fluoxetine or any of its ingredients.
• Take Monoamine Oxidase Inhibitors (MAOIs): Prozac should NOT be taken with or within 14 days of stopping an MAOI (such as isocarboxazid, phenelzine, selegiline, tranylcypromine, linezolid, or intravenous methylene blue). Taking them together can lead to a life-threatening condition called serotonin syndrome, which involves symptoms like agitation, hallucinations, rapid heart rate, confusion, muscle rigidity, and fever. You also need to wait at least 5 weeks after stopping Prozac before starting an MAOI. This extended washout period is crucial due to fluoxetine's long half-life and that of its active metabolite, norfluoxetine, ensuring adequate clearance of the drug from the body to prevent serotonin syndrome.
• Take Pimozide or Thioridazine: These antipsychotic medications are contraindicated with Prozac because fluoxetine is a potent inhibitor of the CYP2D6 enzyme, which metabolizes both pimozide and thioridazine. This significantly increases their plasma concentrations, leading to a heightened risk of serious and life-threatening heart problems, including irregular heart rhythms (QT prolongation). A washout period of at least 5 weeks after stopping Prozac is required before initiating thioridazine.

Tell your doctor about all of your medical conditions, past and present, before starting Prozac. This is crucial because certain conditions affect whether Prozac is right for you. These conditions may include, but are not limited to:
• Bipolar Disorder/Mania: Prozac, when taken alone, can trigger manic or mixed episodes in individuals with bipolar disorder. It's often prescribed in combination with other medications (like olanzapine) for bipolar depression.
• Bleeding Problems: Prozac can increase the risk of bleeding. If you have a bleeding disorder (e.g., hemophilia) or are taking blood thinners (anticoagulants like warfarin or NSAIDs), your risk of bleeding may be higher.
• Diabetes: Prozac can affect blood sugar levels, making it harder to manage diabetes. More frequent blood sugar monitoring may be necessary. • Electroconvulsive Therapy (ECT): Combining Prozac with ECT may increase the risk of seizures.
• Glaucoma (Angle-Closure Type): Prozac can increase pressure in the eye, potentially worsening angle-closure glaucoma.
• Heart Problems: If you have certain heart conditions, such as heart failure, a recent heart attack, or an irregular heart rhythm (especially long QT syndrome), Prozac can worsen these conditions or increase the risk of abnormal heart rhythms.
• Liver Problems: Prozac is metabolized by the liver. If you have liver disease (e.g., cirrhosis), the drug can build up in your body, increasing the risk of side effects. Your doctor may prescribe a lower dose.
• Low Electrolyte Levels: Low sodium, potassium, or magnesium levels in the blood can increase the risk of heart problems when taking Prozac. Your doctor may check these levels before treatment.
• Older Adults (over 65): Elderly patients may be more sensitive to side effects like low sodium levels. • Seizure Disorders: Prozac can increase the risk of seizures. If you have a history of epilepsy or other seizure disorders, your doctor will need to weigh the risks and benefits carefully.
• Young age (under 25): There is a 'boxed warning' (the most serious warning from the FDA) regarding an increased risk of suicidal thoughts and behaviors, as well as an 'activation syndrome' (characterized by agitation, anxiety, and restlessness), in children, adolescents, and young adults (up to age 24) taking antidepressants like Prozac. Close monitoring is essential for these age groups, especially at the beginning of treatment or with dose changes.

Alcohol
Combining Prozac and alcohol can lead to increased sedative effects, dizziness, impaired motor function, and poor decision-making. It's generally advised to avoid alcohol while on Prozac.

Driving and operating machinery
Prozac can cause drowsiness and dizziness, or affect judgment and motor skills. Do not drive or use machinery until you know how it affects you.

Drug Interactions:

Before taking Prozac, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00077360.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Prozac. Prozac may interact with other medicines, but is not limited to:

Do NOT Combine with Prozac (High Risk of Severe Side Effects):
• MAO Inhibitors (MAOIs): These are certain antidepressants (e.g., phenelzine, tranylcypromine) or other drugs like linezolid or methylene blue. Combining them with Prozac can cause a life-threatening condition called serotonin syndrome (symptoms: confusion, agitation, high fever, muscle rigidity, rapid heart rate). There MUST be a "washout" period. Wait at least 2 weeks after stopping an MAOI before starting Prozac, and at least 5 weeks after stopping Prozac before starting an MAOI.
• Pimozide and Thioridazine (Antipsychotics): Combining these with Prozac can lead to serious and potentially fatal heart rhythm problems. Be Very Cautious and Inform Your Doctor (Increased Risk of Side Effects or Reduced Effectiveness):
• Blood Thinners & NSAIDs: Prozac can increase the risk of bleeding. If you take blood thinners (like warfarin, apixaban, rivaroxaban, clopidogrel) or regular NSAIDs (like ibuprofen, naproxen, aspirin), there's an increased risk of bruising or bleeding, especially stomach bleeding.
• Benzodiazepines (e.g., alprazolam, diazepam): Prozac can increase the levels of these drugs, potentially increasing their side effects, such as drowsiness.
• Certain Anticonvulsants (e.g., phenytoin, carbamazepine): Prozac can increase the levels of these drugs, potentially leading to increased side effects. Your doctor may need to adjust doses or monitor blood levels.
• Certain Pain Medications (e.g., Codeine, Tramadol): Prozac can reduce the effectiveness of these opioids by interfering with how your body activates them.
• Medications Affecting Heart Rhythm (QT Prolongation): Prozac can affect heart rhythm. Combining it with other drugs that can prolong the "QT interval" on an EKG can increase the risk of serious irregular heartbeats. Examples include:
o Antipsychotics (e.g., ziprasidone, haloperidol)
o Antiarrhythmic medications (e.g., amiodarone, sotalol)
o Antibiotics (e.g., azithromycin, erythromycin, moxifloxacin)
o Antifungals (e.g., voriconazole)
• Other Serotonin-Increasing Drugs: Taking Prozac with other medications that also increase serotonin can lead to serotonin syndrome, though usually less severe than with MAOIs. These include:
o Other antidepressants (SSRIs, SNRIs, TCAs)
o Certain pain medications (e.g., tramadol, fentanyl, meperidine)
o Migraine medications called "triptans" (e.g., sumatriptan)
o St. John's Wort (herbal supplement)
o Dextromethorphan (in many cough and cold medicines)
o Lithium, Buspirone
• Tamoxifen (Breast Cancer Drug): Prozac can reduce the effectiveness of tamoxifen. Your doctor may recommend a different antidepressant if you are taking tamoxifen.

Other Drugs
Marijuana may cause increased sedative effects, altered mental status, and a potential for hypomania. Using stimulants (e.g., Cocaine, Methamphetamines, or even some prescription stimulants not taken as prescribed) with Prozac is highly dangerous and should be strictly effects (e.g., dangerously high blood pressure, heart attack, arrhythmia), excessive central nervous system stimulation, and a heightened risk of developing life-threatening serotonin syndrome.

Pregnancy and Breastfeeding

The safety of Prozac during pregnancy is not fully established, and it can pass into breast milk, potentially causing side effects in a breastfed infant. The risks and benefits should be discussed with your doctor.

Frequently Asked Questions about Prozac at Canada Pharmacy Online:

Why is Prozac more affordable in Canada than in the United States?

Prescription drug prices, including Prozac, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Prozac 10 mg and 20 mg?

The difference in dosage represents the different amounts of the same active ingredient (fluoxetine) present in each capsule.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many capsules I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Prozac at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Prozac requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Prozac?

Yes, there is a generic alternative for this product called fluoxetine.

Can I stop taking Prozac suddenly?

No, it is generally recommended to gradually reduce your dosage under the guidance of your doctor when stopping Prozac. Suddenly stopping can lead to withdrawal symptoms (sometimes called "discontinuation syndrome"), which may include dizziness, nausea, numbness or tingling, trouble sleeping, agitation, anxiety, headaches, and shaking.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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