Zoloft (Sertraline)

Name: Zoloft
Brand: Viatris
SKU: 2640
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Zoloft Capsule

Manufacturer: Viatris

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Zoloft Tablet

Manufacturer: Pfizer

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Zoloft Tablet

Manufacturer: Viatris

Country: Turkey

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Zoloft (ON BACKORDER)

Manufacturer: Pfizer

Country: India

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Zoloft Capsule

Manufacturer: Viatris

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Zoloft Tablet

Manufacturer: Viatris

Country: Turkey

Dosage: 100 mg

Qty-Price (USD):

Generic Equivalent of Zoloft

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Sertraline Capsule

Manufacturer: Generic

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Sertraline Capsule

Manufacturer: Generic

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Sertraline Tablet

Manufacturer: Generic

Country: United Kingdom

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Sertraline Capsule

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Sertraline Tablet

Manufacturer: Generic

Country: United Kingdom

Dosage: 100 mg

Qty-Price (USD):

Zoloft Information

medically reviewed by Carol Hou (BSc. Pharm) on June 23, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Zoloft and Sertraline at CanadaPharmacyOnline.com

The brand name Zoloft is manufactured by Viatris in Canada. In India, sertraline is marketed under various brand names such as Daxid by multiple manufacturers, including Pfizer. In Turkey, another brand, Lustral, is primarily associated with Viatris in that region.

Generic sertraline is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Sertraline:

Generic sertraline contains the same active ingredient as brand-name Zoloft and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Zoloft. Studies have shown that generic sertraline is bioequivalent to brand-name Zoloft, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

Brand Zoloft and generic sertraline are commonly available in oral tablets and capsules of various strengths, including 25 mg, 50 mg, and 100 mg. Other strengths may also be available.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Zoloft (sertraline) is approved in adults for the treatment of Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder (PD), Post-traumatic Stress Disorder (PTSD), Social Anxiety Disorder (SAD), and Premenstrual Dysphoric Disorder (PMDD). In pediatric populations, sertraline is approved for the treatment of Obsessive-Compulsive Disorder in children and adolescents aged 6 to 17 years.

Mechanism of Action:
Sertraline is classified as a selective serotonin reuptake inhibitor (SSRI). Its primary mechanism of action involves elevating serotonin levels in the brain by blocking the serotonin transporter (SERT) on presynaptic nerve cells. This inhibition prevents serotonin reuptake from the synaptic cleft, leading to increased serotonin availability and enhanced neurotransmission at postsynaptic receptors. Sertraline also binds to the sigma-1 receptor and acts as an antagonist (inhibitor). While sertraline exhibits high selectivity for SERT, it has minimal direct impact on norepinephrine reuptake at therapeutic doses and only weak inhibition of dopamine reuptake, the clinical relevance of which for its approved indications is not well-established.

Take Zoloft exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Zoloft, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Zoloft. It is not an exhaustive list, and individual reactions can vary.

Common Side Effects - These are some common side effects of Zoloft, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms. • Gastrointestinal Issues: Nausea, diarrhea, indigestion, decreased appetite, constipation, vomiting, stomach cramps, gas, or pain. • Nervous System Issues: Dizziness, tremors or shaking, agitation, anxiety, nervousness, headache, fatigue or tiredness. • Other: Increased sweating, dry mouth, weight loss or gain, acid or sour stomach, heartburn, nosebleeds. • Sleep Disturbances: Insomnia (trouble sleeping) or drowsiness. • Sexual Problems: Decreased sex drive, erectile dysfunction (inability to get or keep an erection), delayed or absent ejaculation (in men), difficulty reaching orgasm (in women).

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic Reactions: Skin rash, itching, hives, swelling of the face, lips, tongue, or throat, difficulty breathing.
• Angle-Closure Glaucoma Risk: Sertraline can cause pupillary dilation, which may trigger an episode of angle-closure glaucoma in individuals with narrow eye angles. Symptoms of acute angle-closure glaucoma include sudden eye pain, changes in vision (such as blurred vision or seeing halos around lights), and swelling or redness in or around the eye.
• Blood Pressure Changes: May include orthostatic hypotension (dizziness upon standing). Significant and sustained changes in blood pressure (hypertension or hypotension) are less common but should be monitored.
• Changes in Appetite or Weight: Significant weight gain or loss. Height and weight should be monitored in children and adolescents.
• Heart Rhythm Changes: Sertraline has been associated with a potential, though generally considered low at typical therapeutic doses, for QTc interval prolongation. This risk can be increased in individuals with pre-existing cardiac conditions, particularly a history of QTc prolongation or arrhythmias, or when used concomitantly with other medications that prolong the QTc interval. Careful assessment of individual cardiac risk factors and potential drug interactions is essential before and during treatment.
• Increased Risk of Bleeding: Unusual bleeding or bruising, bloody or black tarry stools, red or dark brown urine, vomiting blood or brown material.
• Liver Problems: In individuals with mild to moderate hepatic impairment, a lower starting dose and careful titration of sertraline are often necessary due to reduced metabolism and an increased risk of side effects. In severe hepatic impairment, sertraline is generally avoided. If, in rare cases, it is deemed essential, it must be used under strict medical supervision with frequent monitoring of liver function and for adverse effects, with a careful assessment of risks versus benefits.
• Low Sodium Levels (Hyponatremia): Headache, weakness, unsteadiness, confusion, trouble concentrating, memory problems. This is more common in elderly patients.
• Manic Episodes: Greatly increased energy, racing thoughts, unusually grand ideas, severe trouble sleeping, reckless behavior, excessive happiness or irritability, talking more or faster than usual.
• Serotonin Syndrome: Can be life-threatening. Symptoms include agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea.
• Seizures or Convulsions.
• Suicidal Thoughts or Actions: New or worsening thoughts of suicide or death, suicide attempts. This is a serious risk, especially in children, adolescents, and young adults under 25 years of age, and during the first few months of treatment or when the dose is changed.
• Unusual Changes in Mood or Behavior: Feeling more depressed, irritable, agitated, hostile, aggressive, impulsive, or restless.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Zoloft, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Zoloft should not be used if:
• You've had a previous allergic reaction to sertraline or its ingredients.
• You are taking MAOIs (Monoamine Oxidase Inhibitors): Do not use sertraline concomitantly with MAOIs or within a washout period after stopping an MAOI. For most non-selective irreversible MAOIs (e.g., phenelzine, isocarboxazid), this washout period is typically at least 14 days due to the risk of serotonin syndrome. While selegiline is primarily a selective MAO-B inhibitor at lower doses, caution is still advised, and your doctor should determine the appropriate washout period.
• You are taking pimozide: This antipsychotic medication should not be used with sertraline due to the increased risk of irregular heart rhythm.

Tell your doctor about all your medical conditions, past and present, before starting Zoloft. This is crucial because certain conditions affect whether Zoloft is right for you. These conditions may include, but are not limited to:
• Bleeding Disorders or Concomitant Use of Blood Thinners: SSRIs, including sertraline, can impair platelet aggregation and increase the risk of bleeding, mainly when used with anticoagulants (e.g., warfarin), antiplatelet agents (e.g., aspirin, clopidogrel), or NSAIDs.
• Heart Problems: Sertraline has been associated with a potential for dose-dependent QTc interval prolongation. While the risk is generally low at typical therapeutic doses, it can be increased in individuals with pre-existing cardiac conditions, particularly a history of QTc prolongation or arrhythmias, or when used concomitantly with other medications that prolong the QTc interval. Careful assessment of individual cardiac risk factors and potential drug interactions is essential before and during treatment.
• History of Bipolar Disorder or Mania: Antidepressants, including sertraline, may increase the risk of a manic or mixed episode in individuals with bipolar disorder. Therefore, a doctor must screen for a history of bipolar disorder before prescribing sertraline.
• Liver Problems: Due to the potential for increased side effects, a lower dose of Zoloft is often necessary in individuals with mild to moderate liver impairment. Zoloft is generally not recommended in severe hepatic impairment. Close monitoring by a healthcare professional is crucial in individuals with liver conditions.
• Low Sodium Levels (Hyponatremia): Zoloft can further lower sodium levels. Your doctor may treat the low sodium before starting Zoloft.
• Narrow Eye Angles (Glaucoma): Zoloft can dilate pupils and may trigger closed-angle glaucoma. An eye exam before starting Zoloft might be recommended.
• Seizures: Zoloft should be used with caution in individuals with seizure disorders as it may lower the seizure threshold, potentially increasing the risk of seizures. The decision to use Zoloft in such individuals requires careful evaluation of the risks and benefits by a physician.
• Suicidal Thoughts and Behavior: Antidepressants may increase the risk of suicidal thoughts and behavior in children, adolescents, and young adults, especially during the initial months of treatment or when the dosage is changed. Close monitoring is necessary.

Drug Interactions:

Before taking Zoloft, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Zoloft prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Zoloft. Zoloft may interact with other medicines but is not limited to:
• Drugs that Prolong the QTc Interval: Concurrent use with other drugs that prolong the QTc interval (e.g., certain antiarrhythmics, antipsychotics, and antibiotics) may increase the risk of ventricular arrhythmias.
• Drugs Metabolized by CYP2D6: Sertraline is a weak to moderate inhibitor of the cytochrome P450 2D6 (CYP2D6) enzyme. This inhibition can potentially lead to increased plasma concentrations of co-administered drugs that are primarily metabolized by CYP2D6, such as some beta-blockers, some tricyclic antidepressants, and some other selective serotonin reuptake inhibitors (SSRIs). The clinical significance of this interaction depends on the specific co-administered drug, its dosage, and the individual patient. Careful consideration by the prescribing physician, including potential dose adjustments and monitoring for adverse effects of the co-administered medications, is crucial.
• Other Serotonergic Drugs: Combining sertraline with other serotonergic drugs necessitates caution due to the increased risk of serotonin syndrome, a potentially life-threatening condition. This includes other selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOIs - contraindicated for concurrent use due to high risk), triptans, tramadol, fentanyl, St. John's Wort, and buspirone. The risk and severity of serotonin syndrome can vary depending on the specific drugs involved and their dosages. Lithium's interaction with SSRIs is complex and can increase the risk of various adverse effects, requiring close monitoring. Similarly, the interaction with amphetamines is complex and warrants careful clinical evaluation.
• Phenytoin: Sertraline can have a complex and unpredictable effect on phenytoin levels. It has been reported to both increase and decrease phenytoin concentrations in different individuals, potentially leading to either phenytoin toxicity or loss of seizure control. Therefore, careful monitoring of phenytoin serum levels is mandatory when sertraline and phenytoin are used concurrently, and dosage adjustments of either medication may be necessary.

Alcohol
It is generally recommended to avoid or limit alcohol consumption while taking Zoloft, as alcohol can worsen some side effects, such as drowsiness and dizziness. It may also exacerbate the symptoms of the condition being treated.

Pregnancy and Breastfeeding

Discuss with your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking Zoloft. Some studies suggest a potential increased risk of specific congenital disabilities or complications in newborns exposed to Zoloft during the later stages of pregnancy. Zoloft can also pass into breast milk. Your doctor can help you weigh the risks and benefits based on your situation.

Frequently Asked Questions about Zoloft at Canada Pharmacy Online:

Why is Zoloft more affordable in Canada than in the United States?

Prescription drug prices, including Zoloft, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

What is the difference between Zoloft 25 mg and 100 mg?

The difference in dosage represents the different amount of the same active ingredient (sertraline) present in each tablet.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets or capsules I can order at once?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Zoloft at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Zoloft requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Zoloft?

Yes, there is a generic alternative for this product called sertraline.

Can I stop taking Zoloft suddenly?

Suddenly stopping Zoloft can cause withdrawal symptoms like nausea, sweating, mood changes, anxiety, confusion, dizziness, headache, and electric shock-like sensations. Always talk to your doctor before stopping Zoloft.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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