Trelegy (Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: United Kingdom

Dosage: 92 mcg/55 mcg/22 mcg/30 dose

Qty-Price (USD):

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: Canada

Dosage: 100 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: United Kingdom

Dosage: 100 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: Australia

Dosage: 100 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: Canada

Dosage: 200 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Type:

Product: Trelegy Ellipta

Manufacturer: GSK

Country: Australia

Dosage: 200 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Generic Equivalent of Trelegy

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate Ellipta

Manufacturer: Generic

Country: India

Dosage: 100 mcg/62.5 mcg/25 mcg/30 dose

Qty-Price (USD):

Trelegy Information

medically reviewed by Carol Hou (BSc. Pharm) on August 21, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Trelegy Ellipta and (Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate) at CanadaPharmacy.com

The brand Trelegy Ellipta, manufactured by GSK, is available in numerous countries globally, including Australia, India, Turkey, the United Kingdom, and Canada.

Generic fluticasone furoate/umeclidinium bromide/vilanterol trifenatate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturers of your dispensed medication may vary.

Important Information about Generic Fluticasone Furoate/Umeclidinium Bromide/Vilanterol Trifenatate

Generic fluticasone furoate/umeclidinium bromide/vilanterol trifenatate contains the same active ingredients as brand-name Trelegy Ellipta and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Trelegy Ellipta. Studies have shown that generic fluticasone furoate/umeclidinium bromide/vilanterol trifenatate is bioequivalent to brand-name Trelegy, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts.

Dosage:

The brand Trelegy Ellipta and its generic components fluticasone furoate, umeclidinium, and vilanterol trifenatate are dry powder inhalers. The available strengths and sizes vary by country. For example, in the United States, the medication is available in strengths of 100 mcg/62.5 mcg/25 mcg/30 dose and 200 mcg/62.5 mcg/25 mcg/30 dose. In Canada, it is available as 92 mcg/55 mcg/22 mcg/30 dose.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol trifenatate) is a dry powder inhaler prescribed for the long-term maintenance treatment of both Chronic Obstructive Pulmonary Disease (COPD) and asthma in adult patients. For COPD, it is indicated to improve lung function and reduce exacerbations in moderate to severe cases, particularly when simpler dual therapies are insufficient. In asthma, it serves as a maintenance therapy for adults whose condition remains inadequately controlled with an inhaled corticosteroid and a long-acting beta-2 agonist combination. It is crucial to note that Trelegy Ellipta functions as a preventive medication and should not be used as a rescue inhaler for acute bronchospasm.

Mechanism of Action:
Trelegy Ellipta works by combining three different medications to help you breathe easier and reduce lung inflammation. One part, fluticasone furoate, is an inhaled steroid that calms inflammation and swelling in your airways. The other two parts are bronchodilators: umeclidinium and vilanterol. Umeclidinium relaxes the airway muscles by blocking specific signals that cause tightening, while vilanterol relaxes them by activating different receptors that open the airways. Together, these three ingredients provide a comprehensive approach to keep your airways open, reduce inflammation, and improve airflow, helping to manage chronic lung conditions like COPD and asthma with a single daily dose.

Take Trelegy Ellipta exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Trelegy Ellipta, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Trelegy Ellipta (fluticasone furoate/umeclidinium bromide/vilanterol trifenatate). It is not an exhaustive list, and individual reactions can vary.

Common side effects - The following are some common side effects of Trelegy Ellipta; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Bronchitis
• Cough
• Diarrhea
• Dry mouth
• Fast heart rate (tachycardia) or tremor
• Headache
• Infections of the upper respiratory tract (e.g., common cold)
• Oral thrush (a fungal infection in the mouth and throat) - Rinsing your mouth with water after each use and spitting it out can help prevent this.
• Urinary tract infection

Other Potential Side Effects (Less Common):
• Anxiety
• Back pain
• Blurred vision or eye irritation
• Chest discomfort
• Constipation
• Dizziness
• High blood pressure (hypertension)
• Muscle spasms
• Nasal congestion or sinusitis
• Nausea or vomiting
• Pain in the mouth or throat
• Sore throat or mouth pain
• Voice changes or hoarseness

Serious and Rare Side Effects: These side effects are rare but potentially severe. Seek immediate medical attention or call emergency services if you experience any of the following:
• Adrenal suppression, which is a reduction in the body's ability to produce natural steroid hormones.
• Cardiovascular events, such as a heart attack, stroke, or severe heart rhythm problems, particularly in patients with pre-existing heart conditions.
• Eye problems, such as an increase in pressure within the eye that may lead to glaucoma.
• High blood sugar (hyperglycemia) or low potassium levels (hypokalemia).
• Immunosuppression and an increased risk of serious infections, such as pneumonia.
• Severe allergic reactions (e.g., hives, swelling of the face, lips, tongue, or throat, or difficulty breathing).
• Sudden worsening of breathing or wheezing immediately after use (paradoxical bronchospasm).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Trelegy Ellipta, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do NOT Use Trelegy Ellipta If:
• You are already taking another medication that contains a long-acting beta2-adrenergic agonist (LABA), as this can increase the risk of serious side effects.
• You are experiencing an acute, life-threatening episode of asthma or COPD. Trelegy Ellipta is a maintenance medication and is NOT a rescue inhaler for sudden breathing problems.
• You have a severe hypersensitivity or a history of allergic reaction to milk proteins, fluticasone furoate, umeclidinium, vilanterol trifenatate, or any other ingredients in the product.

Tell your doctor about all of your medical conditions, past and present, before starting Trelegy Ellipta. This is crucial because certain conditions can affect whether Trelegy Ellipta is right for you. These conditions may include, but are not limited to:
• Cardiovascular disorders, including heart problems, high blood pressure, or irregular heartbeats.
• Convulsive disorders (seizures).
• Diabetes, as Trelegy Ellipta can increase blood sugar levels.
• Eye problems, such as glaucoma, cataracts, or a history of increased eye pressure. Trelegy Ellipta can worsen narrow-angle glaucoma.
• Infections, including active or latent tuberculosis, or any other systemic fungal, bacterial, viral, or parasitic infections. The inhaled steroid component may weaken your immune system.
• Liver impairment, as your body may not clear the medication properly.
• Osteoporosis or other risk factors for weakened bones.
• Thyroid problems, such as hyperthyroidism.
• Urinary problems, such as an enlarged prostate or bladder-neck obstruction, as Trelegy Ellipta can worsen urinary retention.

Drug Interactions:

Before taking Trelegy Ellipta, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official patient medication information by GSK Canada at: https://ca.gsk.com/media/xkcbsuxm/trelegy-ellipta_pm-part-3_en.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, or significant dietary changes, as these could interact with Trelegy Ellipta. Trelegy Ellipta may interact with other medicines, but is not limited to:
• Antidepressants (MAOIs and TCAs) and drugs that prolong the QTc interval can enhance the cardiovascular effects of Trelegy, increasing the risk of severe heart problems.
• Beta-Blockers: can counteract the bronchodilating effect of Trelegy, potentially causing severe breathing problems.
• Diuretics: Using certain diuretics with Trelegy can increase the risk of low potassium levels and heart rhythm problems.
• Other Anticholinergics: Combining Trelegy with other anticholinergic drugs can increase the risk of side effects like dry mouth and urinary retention.
• Strong CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir) can significantly increase the levels of Trelegy in your body, raising the risk of systemic side effects like adrenal suppression.

Pregnancy and Breastfeeding:

The safety of Trelegy Ellipta during pregnancy has not been established. It is unknown if the components of Trelegy Ellipta pass into breast milk in clinically relevant amounts. For both pregnant and breastfeeding individuals, the decision to use Trelegy Ellipta should be made after a careful discussion with a healthcare provider. The risks of uncontrolled asthma or COPD can outweigh the potential risks of the medication to the baby. For this reason, a doctor will weigh the benefits and risks of using Trelegy Ellipta to determine the safest and most effective course of treatment for both you and your baby.

Frequently Asked Questions about Trelegy Ellipta at Canada Pharmacy Online:

Why is Trelegy Ellipta more affordable in Canada than in the United States?

Prescription drug prices, including Trelegy Ellipta, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

How long does it take for Trelegy to work?

A single inhalation of Trelegy once a day can provide 24 hours of improved breathing. It is also proven to reduce COPD flare-ups (exacerbations). The results may vary (source).

Is there a limit on the number of Trelegy I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Trelegy at one time, as per your doctor's prescription.

Can I buy Trelegy over the counter from you?

No, Trelegy requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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