Advair Inhaler (Fluticasone/Salmeterol)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Advair Inhaler

Manufacturer: GSK

Country: New Zealand

Dosage: 50 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler

Manufacturer: GSK

Country: Canada

Dosage: 125 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler ((ON BACKORDER)

Manufacturer: GSK

Country: Turkey

Dosage: 125 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler (ON BACKORDER)

Manufacturer: GSK

Country: Turkey

Dosage: 125 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler

Manufacturer: GSK

Country: Canada

Dosage: 250 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler

Manufacturer: GSK

Country: New Zealand

Dosage: 250 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Advair Inhaler (ON BACKORDER)

Manufacturer: GSK

Country: Turkey

Dosage: 250 mcg/25 mcg/120 dose

Qty-Price (USD):

Generic Equivalent of Advair Inhaler

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Fluticasone/Salmeterol

Manufacturer: Generic

Country: India

Dosage: 50 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Fluticasone/Salmeterol

Manufacturer: Generic

Country: India

Dosage: 125 mcg/25 mcg/120 dose

Qty-Price (USD):

Type:

Product: Fluticasone/Salmeterol

Manufacturer: Generic

Country: India

Dosage: 250 mcg/25 mcg/120 dose

Qty-Price (USD):

Advair Inhaler Information

medically reviewed by Carol Hou (BSc. Pharm) on July 2, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

ADVAIR HFA and Fluticasone/Salmeterol at CanadaPharmacyOnline.com

Brand name ADVAIR HFA (fluticasone/salmeterol) is available from New Zealand (also known as Seretide MDI Inhaler), Turkey (also known as Seretide Inhaler), and Canada by GSK.

Generic fluticasone/salmeterol is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Fluticasone/Salmeterol:

Generic fluticasone/salmeterol contains the same active ingredient as brand-name ADVAIR HFA and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as ADVAIR HFA. Studies have shown that generic fluticasone/salmeterol is bioequivalent to brand-name ADVAIR HFA, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

ADVAIR HFA and its generic equivalents are fluticasone propionate/salmeterol metered-dose inhalers that utilize hydrofluoroalkane (HFA) as a propellant. It is commonly available in the following strengths:
• 50 mcg fluticasone propionate / 25 mcg salmeterol per actuation: delivers approximately 45 mcg of fluticasone and 21 mcg of salmeterol from the mouthpiece.
• 125 mcg fluticasone propionate / 25 mcg salmeterol per actuation: delivers approximately 115 mcg of fluticasone and 21 mcg of salmeterol from the mouthpiece.
• 250 mcg fluticasone propionate / 25 mcg salmeterol per actuation: delivers approximately 230 mcg of fluticasone and 21 mcg of salmeterol from the mouthpiece.

All presentations are typically in a 120-actuation inhaler.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

ADVAIR HFA (fluticasone/salmeterol) is a prescription medication used for the long-term treatment of asthma in adult and adolescent patients aged 12 years and older. ADVAIR HFA helps control asthma symptoms, such as wheezing, shortness of breath, coughing, and chest tightness. It is used as a maintenance treatment to prevent asthma attacks. ADVAIR HFA is typically prescribed for individuals with persistent asthma requiring both an inhaled corticosteroid and a long-acting beta2-adrenergic agonist (LABA) for adequate control. This may include patients whose asthma is not adequately controlled on an inhaled corticosteroid alone or those whose initial presentation warrants combination therapy. Use ADVAIR HFA every day as your doctor prescribes to help prevent symptoms. ADVAIR HFA does not replace a rescue inhaler for sudden breathing problems.

Mechanism of Action:
ADVAIR HFA contains two active ingredients that work together. Fluticasone propionate is an inhaled corticosteroid that reduces inflammation in the lungs and airways by binding to glucocorticoid receptors, leading to a decrease in the release of inflammatory mediators (e.g., cytokines, chemokines) and reducing the activity of inflammatory cells (e.g., eosinophils, mast cells). Salmeterol is a long-acting beta-agonist (LABA) that relaxes the muscles around the airways, helping to open them up and make breathing easier. Salmeterol is a selective beta2-adrenergic receptor agonist. Binding to these receptors on airway smooth muscle cells activates adenylyl cyclase, increasing intracellular cyclic AMP (cAMP) levels. This increase in cAMP leads to bronchodilation by relaxing the smooth muscle. Its long-acting nature is due to its lipophilic side chain, which anchors it to the cell membrane, allowing for prolonged receptor stimulation.

Use ADVAIR HFA exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Always consult your doctor for personalized guidance and to ensure safe and effective use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking ADVAIR HFA, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with ADVAIR HFA (fluticasone/salmeterol). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of ADVAIR HFA, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms.
• Cough
• Dizziness
• Headache
• Hoarseness and voice changes: Your voice may sound different or hoarse.
• Nausea and vomiting
• Oral thrush: This is a fungal infection in the mouth or throat. Rinsing your mouth with water without swallowing after each use can help prevent this.
• Throat irritation: You may experience a scratchy or sore throat.
• Upper respiratory tract infection can include symptoms like a sore throat, runny nose, or cough.

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Symptoms can include rash, hives, swelling of the face, mouth, and tongue, or breathing problems.
• Changes in laboratory blood levels (e.g., sugar, potassium).
• Eye problems include blurred vision, increased pressure in the eye (glaucoma), or cataracts.
• Heart problems include increased blood pressure, fast or irregular heartbeat, or chest pain.
• Increased risk of bone thinning or weakness (osteoporosis) with long-term use.
• Nervous system effects: Including tremors or nervousness.
• Reduced adrenal function: This can occur, particularly when switching from oral to inhaled corticosteroids. The body may have difficulty producing enough natural cortisol, leading to fatigue, lack of energy, weakness, nausea, vomiting, and low blood pressure.
• Signs of infection: Such as fever, chills, increased mucus production, change in mucus color, or increased cough.
• Slowed growth in children. Your child's growth should be monitored regularly by a healthcare provider.
• Worsening breathing problems: Wheezing, chest tightness, or shortness of breath that worsens after using Advair HFA.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting ADVAIR HFA, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

ADVAIR HFA should not be used if you:
• Are allergic to fluticasone, salmeterol, or any of the ingredients in this medication.
• Have acute asthma attack or severe COPD exacerbation: ADVAIR HFA should not be used for acute asthma attacks or severe COPD exacerbations because it contains salmeterol, a long-acting beta2-adrenergic agonist (LABA) with a slower onset of action (typically 20-30 minutes). During acute breathing problems, a fast-acting rescue inhaler (short-acting beta2-agonist like albuterol) is required to provide immediate bronchodilation and relieve symptoms quickly.

Tell your doctor about all your medical conditions, past and present, before starting ADVAIR HFA. This is crucial because certain conditions affect whether ADVAIR HFA is right for you. These conditions may include, but are not limited to:
• Active infections: Before starting Advair HFA, it's important to tell your doctor about any current infections (bacterial, fungal, viral, or parasitic), as it may make it harder for your body to fight them.
• Diabetes: Advair HFA can potentially increase blood sugar levels, making diabetes management more challenging.
• Glaucoma or cataracts: Advair HFA might worsen these eye conditions.
• Heart problems or high blood pressure: Salmeterol, a long-acting beta-agonist in Advair HFA, can sometimes cause heart-related side effects like increased heart rate or blood pressure, which could be problematic for individuals with pre-existing heart conditions.
• High thyroid hormone levels (hyperthyroidism): Advair HFA might worsen symptoms of hyperthyroidism, such as a fast heartbeat.
• Liver problems: The liver helps clear Advair HFA from the body. Liver impairment could lead to a buildup of the drug, increasing the risk of side effects.
• Osteoporosis or risk factors for osteoporosis: Long-term use of inhaled corticosteroids like fluticasone may weaken bones.
• Seizure disorders: In rare cases, Advair HFA may increase the risk of seizures in people with epilepsy or other seizure disorders.
• Weakened immune system: Fluticasone, a corticosteroid in Advair HFA, can weaken the immune system, potentially increasing the risk of infections or worsening existing ones.

Drug Interactions:

Before taking ADVAIR HFA, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official ADVAIR HFA prescribing information | GSK.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with ADVAIR HFA. ADVAIR HFA may interact with other medicines but is not limited to:

Caffeine:
• Combining salmeterol with caffeine may increase blood pressure and heart rate.

Certain antidepressants:
• Monoamine oxidase inhibitors (MAOIs): Using Advair HFA with MAOIs (or within 2 weeks of stopping them) may potentiate salmeterol's effects on the vascular system. Examples include selegiline, phenelzine, and tranylcypromine.
• Tricyclic antidepressants: These can also increase the risk of cardiovascular side effects when used with salmeterol. Examples include amitriptyline, nortriptyline, and clomipramine.

Drugs that can decrease the effectiveness of Advair HFA:
Non-selective beta-adrenergic receptor blocking agents (beta-blockers), such as propranolol, can block beta2-adrenergic receptors in the airways, counteracting the bronchodilatory effects of salmeterol in Advair HFA. Cardioselective beta-blockers (e.g., metoprolol, atenolol), which preferentially target beta-1 receptors, may have less of an antagonistic effect on salmeterol, but should still be used with caution in patients requiring beta-agonists.

Drugs that can increase the risk of side effects of Advair HFA:
• Certain antibiotics: clarithromycin, telithromycin.
• Certain antifungal medications: ketoconazole, itraconazole, posaconazole, voriconazole.
• Certain HIV protease inhibitors: ritonavir, atazanavir, indinavir, nelfinavir, saquinavir, lopinavir.
• Strong CYP3A4 inhibitors: Fluticasone and salmeterol, the active components of Advair HFA, are metabolized by the CYP3A4 enzyme in the liver and intestines. Drugs that strongly inhibit this enzyme can lead to increased blood levels of both fluticasone (potentially increasing the risk of systemic corticosteroid effects like Cushing's syndrome and adrenal suppression) and salmeterol (potentially increasing the risk of cardiovascular side effects).
• The antidepressant nefazodone.
• The small-molecule inhibitor drugs: adagrasib, idelalisib.

Non–potassium–sparing diuretics (water pills):
Non–potassium–sparing diuretics, particularly loop diuretics (e.g., furosemide) and high doses of thiazide diuretics (e.g., hydrochlorothiazide), can increase potassium excretion and lower blood potassium levels. Salmeterol, a component of Advair HFA, can also cause a small decrease in serum potassium. The concurrent use of these medications may increase the risk of hypokalemia (low potassium), which can lead to cardiac arrhythmias. Careful monitoring of potassium levels is advisable in patients using this combination.

Other long-acting beta-agonists (LABAs):
Using Advair HFA with other medications containing LABAs (such as formoterol or arformoterol) can result in an excessive amount of LABA in the body, increasing the risk of cardiovascular side effects.

Other potential interactions:
• Drugs that can prolong the QTc interval: Salmeterol can sometimes prolong the QTc interval (an electrical event in the heart). Using it with other drugs that also prolong the QTc interval may increase the risk of serious heart rhythm problems.
• Dehydroepiandrosterone (DHEA): This supplement might become less effective when used with Advair.
• Echinacea: There's limited evidence, but using echinacea with Advair might potentially make Advair less effective.

Pregnancy and Breastfeeding

Using Advair HFA during pregnancy requires careful consideration and discussion with your doctor, as uncontrolled asthma poses risks to both mother and baby. While not typically first-line, it may be considered if other asthma medications are insufficient. Limited human studies exist, and animal studies suggest potential fetal harm at high doses. For breastfeeding, minimal amounts of fluticasone and salmeterol will likely pass into breast milk. Experts generally consider them acceptable, though monitoring your baby for any unusual symptoms is advised. Ultimately, your doctor will weigh the benefits of Advair HFA for your health against any potential risks to your baby during pregnancy and breastfeeding.

Frequently Asked Questions about ADVAIR HFA at Canada Pharmacy Online:

Why is ADVAIR HFA more affordable in Canada than in the United States?

Prescription drug prices, including ADVAIR HFA, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many inhalers I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of ADVAIR HFA at once, per your doctor's prescription.

Can I buy over the counter from you?

No, ADVAIR HFA requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for ADVAIR HFA?

Yes, there is a generic alternative for this product called fluticasone/salmeterol.

Is Advair HFA a steroid?

Yes, fluticasone propionate, one of the active ingredients in Advair HFA, is a corticosteroid (steroid medication) that reduces lung inflammation. Compared to oral steroids, inhaled steroids have a lower risk of systemic side effects.

What should I do if I miss a dose of Advair HFA?

If you miss a dose, skip that dose and take your next dose at the usual time. Do not take two doses at one time to make up for the missed dose.

How should I store Advair HFA?

Store Advair HFA at room temperature (between 68°F and 77°F or 20°C and 25°C) with the mouthpiece down. The contents are under pressure, so do not puncture or expose them to high heat or open flame. Keep it out of reach of children.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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