Nexletol (Bempedoic Acid)

Name: Nexletol
Brand: Daiichi Sankyo
SKU: 7633
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Nexletol Tablet

Manufacturer: Daiichi Sankyo

Country: United Kingdom

Dosage: 180 mg

Qty-Price (USD):

Type:

Product: Nexletol (UNAVAILABLE)

Manufacturer: Esperion

Country: United States

Dosage: 180 mg

Qty-Price (USD):

Generic Equivalent of Nexletol

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Bempedoic Acid Tablet

Manufacturer: Generic

Country: India

Dosage: 180 mg

Qty-Price (USD):

Nexletol Information

Nexletol and Bempedoic Acid at CanadaPharmacyOnline.com

Nexletol (bempedoic acid) is manufactured by Esperion Therapeutics in the United States and marketed in the United Kingdom (Nilemdo) by Daiichi Sankyo.

The generic bempedoic acid is also available from India. The specific manufacturer of the medication dispensed may vary based on pharmacy inventory. Generic bempedoic acid is sourced from manufacturers that meet applicable regulatory standards.

Important Information about Generic Bempedoic Acid

Generic bempedoic acid contains the same active ingredient as brand-name Nexletol. It must meet the same effectiveness and quality standards. This means it is designed to work like Nexletol. Studies have shown that generic bempedoic acid is bioequivalent to brand-name Nexletol, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

Dosage:

Nexletol (bempedoic acid) is available in the following oral strengths and forms:
• Tablets: 180 mg.

The recommended dose is 180 mg (1 tablet) taken orally once daily, with or without food.

Usage:

Nexletol is used, along with diet and other lipid-lowering medications, to treat adults with heterozygous familial hypercholesterolemia (HeFH), an inherited condition causing high LDL ("bad") cholesterol, or adults with established cardiovascular disease who need additional LDL-C lowering. It is also used to help reduce the risk of heart attack and the need for coronary revascularization in adults at increased cardiovascular risk. It is also used to help reduce the risk of heart attack and the need for coronary revascularization in adults at increased cardiovascular risk.

Mechanism of Action
Bempedoic acid, the active ingredient in Nexletol, is a prodrug that is activated only inside liver cells, where an enzyme specific to the liver converts it into its active form. Once activated, it inhibits ATP-citrate lyase, an enzyme that sits one step earlier than HMG-CoA reductase in the pathway the liver uses to make cholesterol. Because activation occurs almost exclusively in the liver rather than in muscle tissue, bempedoic acid lowers LDL cholesterol, which is generally associated with a lower risk of muscle-related side effects seen with statins.

Take Nexletol exactly as your doctor prescribes, according to the patient information leaflet. Store it in its original packaging at room temperature, and do not discard the desiccant packet, which helps keep the medication dry.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Nexletol, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Nexletol (bempedoic acid). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Nexletol; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Back, shoulder, leg, or arm pain
• Cold or flu-like symptoms
• Muscle spasms
• Stomach pain

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• High Uric Acid (Gout): Severe foot pain, especially in the toe joint, along with warm, swollen, or tender joints.
• Severe Allergic Reaction: Rash, itching, or swelling of the face, tongue, or throat.
• Tendon Rupture or Injury: Sudden pain, swelling, bruising, or difficulty moving a joint, particularly in the shoulder, hand, or heel.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Nexletol, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Nexletol if: • Allergies: You have a known hypersensitivity to bempedoic acid or any of the tablet's ingredients.

Tell your doctor about all of your medical conditions, past and present, before starting Nexletol. This is crucial as certain conditions affect the drug's safety.
• History of Gout.
• Severe Kidney or Liver Problems.
• Tendon Problems.

Drug Interactions:

Before taking Nexletol, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00082429.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Nexletol. Nexletol may interact with other medicines, including but not limited to:
• Simvastatin and Pravastatin: Nexletol raises the blood levels of these statins, increasing the risk of muscle pain or injury. Coadministration with simvastatin doses greater than 40 mg is contraindicated, and pravastatin doses above 40 mg should generally be avoided while taking Nexletol.

Pregnancy and Breastfeeding:

Nexletol has not been studied in pregnant women, and pregnancy should be ruled out before starting treatment. It is not recommended during pregnancy or while breastfeeding. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

The safety and effectiveness of Nexletol have not been established in children under 18 years of age, and no data are available to support its use in this age group.

Frequently Asked Questions about Nexletol at Canada Pharmacy Online

Why is Nexletol more affordable in Canada than in the United States?

Prescription drug prices, including Nexletol, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Nexletol I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Nexletol per prescription from your doctor.

Can I buy Nexletol from you over the counter?

No, Nexletol requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Nexletol?

Yes, the generic alternative is available.

Blog Post:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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