Nexlizet (Bempedoic Acid/Ezetimibe)

Name: Nexlizet
Brand: Daiichi Sankyo
SKU: 7643
Availability: InStock

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Qty-Price (USD)

Type:

Product: Nexlizet Tablet

Manufacturer: Daiichi Sankyo

Country: United Kingdom

Dosage: 180 mg/10 mg

Qty-Price (USD):

Generic Equivalent of Nexlizet

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There is no generic product of Nexlizet.

Nexlizet Information

medically reviewed by Carol Hou (BSc. Pharm) on July 18, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Nexlizet at CanadaPharmacyOnline.com

Nexlizet is a brand-name medication developed and marketed by Esperion Therapeutics in the United States. The same medication is available in the United Kingdom and other European regions under the brand name Nustendi, where Daiichi Sankyo commercializes it through a licensing agreement with Esperion.

Generic bempedoic acid/ezetimibe is currently unavailable (at this pharmacy).

Dosage

Nexlizet is commonly available in 180 mg/10 mg oral tablets (180 mg bempedoic acid and 10 mg ezetimibe).

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage

Nexlizet (bempedoic acid/ezetimibe) is a prescription medication used, along with diet and exercise, to lower low-density lipoprotein (LDL, or "bad") cholesterol in adults. It is typically prescribed for individuals with: • Established atherosclerotic cardiovascular disease (ASCVD) or those at high risk for a cardiovascular event but without established ASCVD, who need additional lowering of LDL-C, with or without a statin. • Heterozygous familial hypercholesterolemia (HeFH).

Esperion filed a New Drug Submission (NDS) with Health Canada in December 2024 for Nexlizet (bempedoic acid and ezetimibe). This medication is designed to reduce low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk. Health Canada approval for NEXLIZET is anticipated by the end of 2025, with HLS Therapeutics Inc. responsible for its commercialization in Canada.

Mechanism of Action
Nexlizet (bempedoic acid/ezetimibe) works to reduce elevated LDL-C through a dual mechanism of action. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver. Ezetimibe is a dietary cholesterol absorption inhibitor that acts at the brush border of the small intestine, blocking the absorption of dietary cholesterol and cholesterol from bile. The combination of these two active ingredients provides complementary mechanisms to lower cholesterol levels.

Take Nexlizet exactly as your doctor prescribes, following the instructions in the patient information leaflet | Esperion. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Nexlizet, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Nexlizet, it's crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects - These are some common side effects of Nexlizet; other side effects are also possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Anemia
• Back pain
• Bronchitis
• Constipation
• Diarrhea
• Fatigue
• Flu-like symptoms or common cold symptoms
• Increased liver enzymes
• Increased uric acid levels in the blood (hyperuricemia)
• Joint pain (arthralgia)
• Muscle spasms
• Nasopharyngitis (swelling of the nose and throat)
• Pain in the shoulder, legs, or arms
• Sinusitis (swelling of the sinuses)
• Stomach pain, abdominal pain, or discomfort
• Urinary tract infection

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Swelling of your face, lips, mouth, or tongue, wheezing, severe itching, fast heartbeat or pounding in your chest, trouble breathing, skin rashes, redness, or swelling, dizziness or fainting.
• Gallstones (cholelithiasis).
• Gout: Symptoms include severe foot pain (especially in the toe joint), warm joints, swelling, tender joints, or joint redness, due to increased uric acid levels in the blood.
• Kidney problems: Can include decreased glomerular filtration rate, increased blood creatinine levels, and hematuria.
• Tendon rupture or injury: This can happen in people taking bempedoic acid. Symptoms may include a sudden snap or pop, pain, swelling, or bruising in a tendon area (e.g., the Achilles tendon or rotator cuff).

Long-Term Side Effects - Long-term use of Nexlizet requires monitoring for:
• Increased liver enzymes.
• Increased uric acid levels can lead to the development of gout.
• Potential for kidney problems and gallstones.
• Tendon rupture or injury.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Nexlizet, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Nexlizet should not be used if you:
• Have a known hypersensitivity or allergic reaction to bempedoic acid, ezetimibe, or any of its ingredients. Hypersensitivity reactions, including anaphylaxis, angioedema, rash, and urticaria, have been reported with ezetimibe.

Tell your doctor about all of your medical conditions, past and present, before starting Nexlizet. This is crucial because certain conditions affect whether Nexlizet is right for you. These conditions may include, but are not limited to:
• Gout: Nexlizet may increase blood uric acid levels, potentially leading to or worsening gout attacks.
• History of tendon problems or tendon rupture: Nexlizet can increase the risk of tendon rupture.
• Kidney problems: Nexlizet may cause or worsen kidney problems.
• Liver problems: Nexlizet can cause elevated liver enzymes. Use with caution in individuals with moderate to severe liver problems.

Drug Interactions

Before taking Nexlizet, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official Nexlizet website at https://www.nexlizethcp.com/.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Nexlizet. Nexlizet may interact with other medicines, but is not limited to:
• Bile Acid Sequestrants (e.g., cholestyramine, colesevelam, colestipol): These can decrease the absorption and effectiveness of ezetimibe. Nexlizet should be administered at least 2 hours before or at least 4 hours after taking bile acid sequestrants.
• Certain Statins (e.g., simvastatin, pravastatin, lovastatin): Coadministration of Nexlizet with certain statins can increase the risk of muscle pain or weakness (myopathy). Specifically, doses of simvastatin exceeding 20 mg, pravastatin exceeding 40 mg, and lovastatin exceeding 20 mg should be avoided due to an increased risk of muscle pain or weakness (myopathy). Careful monitoring for adverse effects is recommended when using atorvastatin and rosuvastatin. • Cyclosporine: Concurrent use with Nexlizet can increase exposure to both ezetimibe and cyclosporine. Caution is advised, and cyclosporine conc
entrations should be monitored.
• Fibrates (e.g., gemfibrozil, fenofibrate): Coadministration of Nexlizet with fibrates (other than fenofibrate) is not recommended. Fenofibrate and ezetimibe may increase cholesterol excretion into the bile, potentially leading to the formation of gallstones.
• Fluoroquinolone antibiotics (e.g., ciprofloxacin, levofloxacin): concomitant use with Nexlizet may increase the risk of tendon rupture or injury as both medications can lead to this adverse effect.
• Warfarin: Monitoring of International Normalized Ratio (INR) may be necessary.

Pregnancy and Breastfeeding

The safety of Nexlizet during pregnancy has not been fully established. Based on its mechanism of action (decreasing cholesterol synthesis), Nexlizet may cause fetal harm and should be discontinued once pregnancy is recognized, unless the benefits of therapy outweigh the potential risks to the fetus. Hyperlipidemia is generally not a condition that needs to be treated during pregnancy. The effects of bempedoic acid and ezetimibe on breast milk are unknown. Due to the potential for severe adverse reactions in a breastfed infant (as Nexlizet decreases cholesterol synthesis and possibly other biologically active substances derived from cholesterol), breastfeeding is not recommended during treatment with Nexlizet.

Use in Children

The safety and effectiveness of Nexlizet in pediatric patients (under 18 years of age) have not been established.

Use in Older Adults

Elderly patients on Nexlizet must be closely monitored by their healthcare provider. Older adults may be at an increased risk of tendon rupture or injury. They may also be more susceptible to other side effects due to age-related changes in kidney and liver function, as well as the use of concomitant medications. The risk of tendon problems while taking Nexlizet is higher in individuals over 60 years of age.

Frequently Asked Questions about Nexlizet at Canada Pharmacy Online:

Why is Nexlizet more affordable in Canada than in the United States?

Prescription drug prices, including Nexlizet, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Nexlizet at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Nexlizet requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take bempedoic acid and ezetimibe?

Nexlizet should be taken once daily. It can be taken with or without food. If you are also taking a bile acid sequestrant, take Nexlizet at least 2 hours before or 4 hours after the bile acid sequestrant.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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