Rybelsus (Semaglutide)

Name: Rybelsus
Brand: Novo Nordisk
SKU: 7645
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Rybelsus Tablet

Manufacturer: Novo Nordisk

Country: India

Dosage: 3 mg

Qty-Price (USD):

Type:

Product: Rybelsus Tablet (EXPIRY 01/26)

Manufacturer: Novo Nordisk

Country: United Kingdom

Dosage: 3 mg

Qty-Price (USD):

Type:

Product: Rybelsus Tablet

Manufacturer: Novo Nordisk

Country: Denmark

Dosage: 7 mg

Qty-Price (USD):

Type:

Product: Rybelsus Tablet

Manufacturer: Novo Nordisk

Country: United Kingdom

Dosage: 7 mg

Qty-Price (USD):

Type:

Product: Rybelsus Tablet

Manufacturer: Novo Nordisk

Country: Denmark

Dosage: 14 mg

Qty-Price (USD):

Type:

Product: Rybelsus Tablet

Manufacturer: Novo Nordisk

Country: United Kingdom

Dosage: 14 mg

Qty-Price (USD):

Generic Equivalent of Rybelsus

Type

Product

Manufacturer

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Qty-Price (USD)

There is no generic product of Rybelsus.

Rybelsus Information

medically reviewed by Carol Hou (BSc. Pharm) on August 19, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Rybelsus at CanadaPharmacyOnline.com

The brand-name medication Rybelsus, manufactured by Novo Nordisk, is available in many countries worldwide, including India and the United Kingdom.

The generic version is currently unavailable (at our this pharmacy).

Dosage:

The brand name Rybelsus is commonly available in strengths of 3 mg, 7 mg, and 14 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Rybelsus (semaglutide) is an oral medication mainly used for adults with type 2 diabetes to better control their blood sugar levels. It is often prescribed with diet and exercise, which can help with weight loss. It is important to note that Rybelsus is not designed for type 1 diabetes.

Mechanism of Action:
Rybelsus works by mimicking a natural gut hormone called GLP-1. The main ingredient, semaglutide, helps your body manage type 2 diabetes in several key ways: it signals your pancreas to release more insulin when your blood sugar is high, it reduces the amount of sugar your liver produces, and it slows down how quickly food leaves your stomach. These actions help lower blood sugar levels and can also assist with weight loss by making you feel fuller.

Take Rybelsus exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Rybelsus, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Rybelsus (semaglutide). It is not an exhaustive list, and individual reactions can vary.

Common side effects – These are common side effects of Rybelsus, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain
• Constipation
• Decreased appetite
• Diarrhea
• Nausea
• Vomiting

Other Potential Side Effects (less common):
• Acid or sour stomach
• Belching
• Bloating
• Dizziness
• Excess air or gas in the stomach
• Fatigue
• Feeling pressure in the stomach
• Gastritis
• Gastroesophageal reflux disease (GERD)
• Headache
• Heartburn
• Indigestion
• Low blood sugar (hypoglycemia) (mainly when used with insulin or sulfonylureas)
• Passing gas
• Stomach discomfort, swelling, tenderness, or upset
• Weight loss (can be a beneficial effect, but is also listed as a side effect)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions (severe, including anaphylaxis, angioedema, hives, rash, swelling of face/lips/tongue/throat, difficulty breathing)
• Changes in vision (worsening of diabetic retinopathy)
• Gallbladder problems (e.g., gallstones, inflammation, with symptoms like severe upper stomach pain, fever, clay-colored stools, jaundice)
• Kidney problems (including kidney failure, with symptoms like decreased urination, swelling, unusual tiredness)
• Low blood sugar (hypoglycemia, particularly if taking other diabetes medications like insulin or sulfonylureas, with symptoms like anxiety, blurred vision, confusion, dizziness, fast heartbeat, feeling jittery, hunger, irritability, light-headedness, mood changes, shakiness, slurred speech, sweating, weakness)
• Pancreatitis (inflammation of the pancreas, with symptoms like severe and constant stomach pain radiating to your back, with or without vomiting, fast heart rate)
• Possible thyroid tumors, including cancer (symptoms may include a lump or swelling in the neck, trouble swallowing, hoarse voice, shortness of breath)
• Pulmonary aspiration (food or liquid getting into the lungs during surgery or procedures requiring anesthesia)
• Severe stomach problems (e.g., severe nausea, vomiting, or diarrhea leading to dehydration)

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Rybelsus, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Rybelsus should not be used if you:
• You have a personal or family history of medullary thyroid carcinoma (MTC).
• You have multiple endocrine neoplasia syndrome type 2 (MEN 2).
• You have a known hypersensitivity or allergic reaction to semaglutide or any of the ingredients in Rybelsus.

Drug Interactions:

Before taking Rybelsus, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official Rybelsus website: https://www.rybelsus.com/.

Provide your doctor with a complete list of all your medications, including over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Rybelsus. Rybelsus may interact with other medicines, but is not limited to: • Angiotensin II Receptor Blockers (ARBs), such as candesartan or losartan, may increase the risk of low blood sugar.
• Beta-blockers, such as metoprolol or propranolol, can hide some typical symptoms of low blood sugar, like a fast heartbeat, making it harder to recognize hypoglycemia.
• Bismuth Subsalicylate (e.g., Pepto-Bismol): Could raise the risk of low blood sugar.
• CE Inhibitors (Angiotensin-Converting Enzyme Inhibitors): Lisinopril or ramipril may increase the risk of low blood sugar.
• Corticosteroids, such as prednisone or dexamethasone, can raise blood sugar levels, potentially making Rybelsus less effective at controlling blood sugar.
• Diuretics (Water Pills): Furosemide or torsemide may increase blood sugar, making Rybelsus less effective.
• Insulin: Taking Rybelsus with insulin can significantly increase the risk of low blood sugar (hypoglycemia). Your doctor may need to adjust your insulin dose.
• Levothyroxine: Rybelsus can affect the absorption of levothyroxine (a thyroid hormone medication), potentially increasing its levels in the body. Close monitoring is advised.
• Meglitinides: Repaglinide or nateglinide, which stimulate insulin release, can increase the risk of low blood sugar when taken with Rybelsus. Your doctor may need to lower your meglitinide dose.
• Other Oral Medications: Because Rybelsus slows down gastric emptying, it can affect how other oral medications are absorbed. This is particularly important for drugs with a narrow therapeutic window (where small changes in dose can have significant effects). Always tell your doctor about all oral medications you are taking.
• Salicylates, Such as aspirin, may increase the risk of low blood sugar.
• Sulfonylureas: Glipizide or glyburide, which stimulate insulin release, can significantly increase the risk of low blood sugar when taken with Rybelsus. Your doctor may need to lower your sulfonylurea dose.
• Warfarin: Rybelsus may affect the absorption of warfarin (a blood thinner), increasing the risk of side effects. Close monitoring of blood clotting is necessary.

Pregnancy and Breastfeeding:

Rybelsus is generally not recommended if you are pregnant, planning to become pregnant, or breastfeeding. For women who could become pregnant, it's advised to stop taking Rybelsus at least two months before a planned pregnancy because the medication stays in your system for some time, and there isn't enough human data to confirm its safety during pregnancy. Similarly, breastfeeding is not recommended while on Rybelsus, as it's unknown if the medication passes into breast milk and could potentially affect a nursing infant. Discuss the risks and benefits with your doctor.

Use in Children:

Rybelsus is not approved for use in children or adolescents under 18. Its safety and effectiveness in this younger age group have not been studied, so it is only prescribed for adults with type 2 diabetes. If a child or teenager needs diabetes management or weight support, their doctor will consider other treatments specifically approved and proven safe for their age.

Frequently Asked Questions about Rybelsus at Canada Pharmacy Online:

Why is Rybelsus more affordable in Canada than in the United States?

Prescription drug prices, including Rybelsus, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Can I buy Rybelsus over the counter from you?

No, Rybelsus requires a prescription from your doctor. We are unable to sell this product without a valid prescription.

Is there a limit on how many Rybelsus tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Rybelsus at once, per your doctor's prescription.

Can you take two 7 mg tablets of Rybelsus if your doctor prescribes Rybelsus 14 mg?

No, this is not recommended. If you are prescribed 14 mg daily, you should take one 14 mg tablet daily. Always follow the prescription and instructions from your physician or healthcare provider.

Blog Posts:

Insulin Resistance: Are You at Risk for Developing Diabetes?
Why is Fatty Liver Disease on The Rise?

Latest News:

Diabetes patients could be offered weight loss jabs sooner in major shake-up (article published August 19, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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