Dificid (Fidaxomicin)

Name: Dificid
Brand: Merck
SKU: 7087
Availability: InStock

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Product

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Dosage

Qty-Price (USD)

Type:

Product: Dificid Tablet

Manufacturer: Merck

Country: Canada

Dosage: 200 mg

Qty-Price (USD):

Type:

Product: Dificid Tablet

Manufacturer: Astellas Pharma

Country: United Kingdom

Dosage: 200 mg

Qty-Price (USD):

Generic Equivalent of Dificid

Type

Product

Manufacturer

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Qty-Price (USD)

There is no generic product of Dificid.

Dificid Information

Dificid at CanadaPharmacyOnline.com

The manufacturer of Dificid (fidaxomicin) is Merck & Co. (known as MSD outside the U.S. and Canada). In Canada, Dificid is marketed by Merck Canada Inc. It is a specialized, narrow-spectrum macrocyclic antibiotic specifically developed to treat targeted gastrointestinal infections.

The generic fidaxomicin is currently unavailable (at this pharmacy).

Dosage:

Dificid is available in the following oral strengths and forms:
• Tablets: 200 mg (typically film-coated, capsule-shaped, and white to off-white).

The standard adult dosage for treating Clostridioides difficile infection is one 200 mg tablet taken twice daily (every 12 hours) for 10 days.

Usage:

Dificid is primarily used to treat Clostridioides difficile-associated diarrhoea (CDAD), a severe infection of the colon that often occurs after a patient has taken other antibiotics. C. diff can cause symptoms ranging from mild diarrhea to life-threatening inflammation of the bowel. Dificid is unique because it is minimally absorbed by the bloodstream. Instead, it stays within the gastrointestinal tract where the infection is located. This allows the drug to reach very high concentrations exactly where it is needed. Because it is an antibiotic, Dificid only works against bacterial infections; it will not treat viral infections like the stomach flu or the common cold. It is essential to finish the entire 10-day course, even if symptoms improve quickly, to ensure the bacteria are fully eliminated.

Mechanism of Action
Fidaxomicin, the active ingredient in Dificid, is a macrocyclic antibiotic that inhibits the production of essential bacterial proteins. It acts as a potent inhibitor of the bacterial enzyme RNA polymerase. Specifically, it binds to a part of the enzyme that prevents it from initiating transcription of DNA into RNA. Without RNA, the bacteria cannot produce the proteins they need to survive, grow, or release harmful toxins. Because fidaxomicin targets a specific site on the enzyme that is different from that targeted by other antibiotics (like rifampin), it is effective even against strains that may be resistant to other treatments. Its bactericidal (bacteria-killing) action is highly selective for C. diff, helping preserve the natural, healthy gut flora during treatment.

Take Dificid exactly as your doctor prescribes, following the instructions in the product monograph. You can take the tablets with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Dificid, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Dificid (fidaxomicin). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Dificid; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal (stomach) pain
• Anemia
• Gastrointestinal hemorrhage (rare but reported)
• Nausea
• Vomiting

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, lips, or throat, hives, and difficulty breathing.
• Severe Skin Reactions: Widespread rash, blistering, or peeling of the skin.
• Worsening Symptoms: If diarrhea worsens significantly, or if you develop a high fever and severe stomach cramping, seek medical attention.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Dificid, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Dificid/fidaxomicin if:
• Allergies: You have a known hypersensitivity to fidaxomicin or any other ingredients in the medication.

Tell your doctor about all of your medical conditions, past and present, before starting Dificid. This is crucial as certain conditions affect the drug's safety.
• Inflammatory Bowel Disease: Tell your doctor if you have conditions such as Crohn's disease or Ulcerative Colitis.
• Macrolide Allergy: If you are allergic to macrolide antibiotics (like erythromycin or azithromycin), use caution, as there is a potential for cross-sensitivity.
• Severe Kidney or Liver Disease: While the drug is not absorbed significantly into the blood, patients with severe organ impairment should be monitored.

Drug Interactions:

Before taking Dificid, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the product monograph at https://www.merck.ca/en/wp-content/uploads/sites/20/2021/04/DIFICID-PM_E.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Dificid. Dificid may interact with other medicines, including but not limited to:
• Cyclosporine: May slightly increase fidaxomicin levels in some patients.
• Other Antibiotics: Discuss if you are taking other treatments for C. diff, such as vancomycin, as they can affect how Dificid is processed in your body.

Pregnancy and Breastfeeding:

Dificid should be used during pregnancy only if clearly needed. There is limited data on its use in pregnant women, though animal studies have not shown harm. It is unknown if fidaxomicin passes into breast milk. However, because absorption into the mother's blood is so low, the risk to the infant is considered minimal. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

Dificid is approved for use in pediatric patients as young as 6 months old. For children, the dose is determined by the healthcare provider based on the child's weight, often utilizing the oral suspension form.

Frequently Asked Questions about Dificid at Canada Pharmacy Online

Why is Dificid more affordable in Canada than in the United States?

Prescription drug prices, including Dificid, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Dificid I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Dificid per prescription from your doctor.

Can I buy Dificid from you over the counter?

No, Dificid requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Dificid?

No, the generic fidaxomicin is currently unavailable (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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