Parnate (Tranylcypromine)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Parnate

Manufacturer: GSK

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Generic Equivalent of Parnate

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Tranylcypromine

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Parnate Information

Parnate and Tranylcypromine at CanadaPharmacyOnline.com

The manufacturer of brand-name Parnate (tranylcypromine sulfate) is GlaxoSmithKline (GSK). It is available in many countries worldwide, including Canada.

Generic tranylcypromine is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards of Health Canada and the FDA. Common generic manufacturers include Novitium Pharma and Strides Pharma. Generic tranylcypromine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Tranylcypromine

Generic tranylcypromine contains the same active ingredient as brand-name Parnate. It must meet the same effectiveness and quality standards. This means it is designed to work like Parnate. Studies have shown that generic tranylcypromine is bioequivalent to brand-name Parnate, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Parnate (tranylcypromine) is available in the following strengths and forms:
• Tablet: 10 mg oral tablet

Dosage depends on the individual condition. The standard adult dose usually starts at 20 mg per day, divided if needed. If no response occurs after 2–3 weeks, the dosage is increased to 30 mg. Dosage increases are usually made gradually (every 1 to 3 weeks) to monitor for side effects, particularly changes in blood pressure.

Usage:

Parnate is used for the treatment of major depressive disorder (MDD) in adult patients who have not responded adequately to other, more commonly used antidepressants. Because of its potential for serious drug and food interactions, it is rarely used as a first-line treatment. It is especially effective for atypical depression or treatment-resistant cases where other medications have failed.

Mechanism of Action
Tranylcypromine, the active ingredient in Parnate, increases levels of important mood-regulating chemicals in the brain. It belongs to the monoamine oxidase inhibitor (MAOI) class and inhibits the enzyme monoamine oxidase (MAO). In a typical brain, this enzyme acts as a cleanup crew, breaking down neurotransmitters such as serotonin, norepinephrine, and dopamine. By inhibiting this enzyme, Parnate allows these chemicals to remain active in the brain for longer. This increase in chemical signaling helps to lift mood, improve energy levels, and reduce the deep feelings of sadness or hopelessness associated with severe depression.

Take Parnate exactly as your doctor prescribes, following the product monograph. It is crucial to follow a low-tyramine diet while taking this medication and for two weeks after stopping it, as certain foods can cause a dangerous spike in blood pressure. Avoid excess caffeine and alcohol, as they can interact with Parnate, triggering a crisis.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Parnate, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Parnate (tranylcypromine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Parnate; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Blurred vision
• Dizziness or lightheadedness (especially when standing up)
• Drowsiness
• Dry mouth
• Loss of appetite
• Nausea
• Trouble sleeping (insomnia)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Chest Pain or enlarged pupils.
• Heart Palpitations: Fast, pounding, or irregular heartbeat.
• Nausea and Vomiting accompanied by a cold sweat or fever.
• Neck Stiffness or soreness.
• Severe Headache: Especially at the back of the head.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Parnate, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Parnate/tranylcypromine if:
• Allergies: You have a known hypersensitivity to tranylcypromine

Tell your doctor about all of your medical conditions, past and present, before starting Parnate. This is crucial as certain conditions affect the drug's safety.
• A history of stroke or cerebrovascular defects
• Cardiovascular Disease: Including high blood pressure or heart disease.
• Pheochromocytoma: A specific type of adrenal gland tumor.
• Severe liver or kidney disease.

Drug Interactions:

Before taking Parnate, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://pdf.hres.ca/dpd_pm/00034400.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Parnate. You must wait at least 14 days when switching between Parnate and many other medications. Parnate may interact with other medicines, including but not limited to:
• Buspirone: Taking this medicine with Parnate can cause significant blood pressure spikes.
• Decongestants: Over-the-counter cold and flu medicines containing pseudoephedrine or phenylephrine.
• Other Antidepressants: Especially SSRIs (like Prozac), certain TCAs (like clomipramine), or SNRIs, which can cause life-threatening Serotonin Syndrome.
• Pain Medications: Specifically, meperidine (Demerol).
• Stimulants: Including ADHD medications and certain weight-loss drugs.

Pregnancy and Breastfeeding:

Parnate should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is limited data on its safety in human pregnancy. Tranylcypromine is excreted in breast milk. Due to the potential for serious adverse reactions in the nursing infant, a decision should be made whether to discontinue nursing or the drug.

Use in Children:

Parnate is not approved for use in pediatric patients. The safety and effectiveness in children under 18 years of age have not been established.

Frequently Asked Questions about Parnate at Canada Pharmacy Online

Why is Parnate more affordable in Canada than in the United States?

Prescription drug prices, including Parnate, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Parnate I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Parnate per prescription from your doctor.

Can I buy Parnate from you over the counter?

No, Parnate requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Parnate?

Yes, there is a generic alternative to Parnate: tranylcypromine.

Blog Post:

7 Natural Antidepressants That Might Surprise You

Latest News:

Depression may start with an energy problem in brain cells (news published on March 12, 2026)

Similar Drugs in the category of Antidepressant Drugs:

Wellbutrin XL Trintellix Lexapro Effexor XR Cymbalta

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers