Cymbalta (Duloxetine)

Name: Cymbalta
Brand: Eli Lilly
SKU: 2610
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Cymbalta Capsule

Manufacturer: Eli Lilly

Country: European Union

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Cymbalta Capsule (ON BACKORDER)

Manufacturer: Eli Lilly

Country: Turkey

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Cymbalta Capsule

Manufacturer: Eli Lilly

Country: European Union

Dosage: 60 mg

Qty-Price (USD):

Type:

Product: Cymbalta Capsule (ON BACKORDER)

Manufacturer: Eli Lilly

Country: Turkey

Dosage: 60 mg

Qty-Price (USD):

Type:

Product: Cymbalta Capsule (ON BACKORDER)

Manufacturer: Eli Lilly

Country: Australia

Dosage: 60 mg

Qty-Price (USD):

Generic Equivalent of Cymbalta

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Duloxetine Tablet

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: United Kingdom

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: India

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 60 mg

Qty-Price (USD):

Type:

Product: Duloxetine Capsule

Manufacturer: Generic

Country: United Kingdom

Dosage: 60 mg

Qty-Price (USD):

Cymbalta Information

medically reviewed by Carol Hou (BSc. Pharm) on April 30, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Cymbalta and Duloxetine at CanadaPharmacyOnline.com

Brand Cymbalta is manufactured by Eli Lilly and is available in many countries worldwide, including some countries within the European Union, Turkey, and Australia.

Generic duloxetine is sourced from manufacturers meeting applicable local regulatory standards. The specific manufacturer of dispensed medication may vary.

Important Information about Generic Duloxetine:

Generic duloxetine contains the same active ingredient as brand-name Cymbalta and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Cymbalta. Studies have demonstrated bioequivalence between generic and brand-name duloxetine, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about using generic duloxetine.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Brand Cymbalta and generic duloxetine are commonly available in 30 mg and 60 mg oral delayed-release capsules. Generic duloxetine is commonly available in delayed-release capsules, mirroring the brand name. The 20mg gastro-resistant tablet formulation is less common in generic forms. The availability of other formulations should be checked per country.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Cymbalta (duloxetine) is a prescription medication primarily used in adults to treat major depressive disorder (MDD). This medication is also used for generalized anxiety disorder (GAD) in adults, diabetic peripheral neuropathy (nerve pain from diabetes) in adults, fibromyalgia (widespread muscle pain and fatigue) in adults, and chronic musculoskeletal pain in adults, encompassing osteoarthritis pain and chronic lower back pain. (source: the product labeling information)

Mechanism of Action:
Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by inhibiting the reuptake of serotonin and norepinephrine in the brain and central nervous system, thereby increasing their levels in the synaptic space. This action is believed to contribute to its therapeutic effects in treating depression, anxiety, and certain pain conditions. (source: the National Library of Medicine)

Take Cymbalta exactly as your doctor prescribes, following the instructions in the patient information leaflet accompanying the medication. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Cymbalta, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Cymbalta (duloxetine). It is not an exhaustive list, and individual reactions can vary. This information is for educational purposes and should not replace professional medical advice. Before starting Cymbalta, it is crucial to discuss possible side effects and risks with your doctor or pharmacist.

Common side effects - These are some common side effects of Cymbalta, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning or if you experience any other concerning symptoms.
• Body aches or pain;
• Blurred vision;
• Gastrointestinal issues (abdominal pain, dry mouth, constipation, diarrhea, decreased appetite, nausea (very common in the first week), vomiting);
• Increased sweating;
• Muscle pain or cramps;
• Nervous system issues (anxiety, agitation, dizziness, drowsiness, headache, insomnia, tremor);
• Sore throat;
• Sexual side effects (decreased libido, erectile dysfunction, difficulty reaching orgasm);
• Weight changes (both weight loss or weight gain)

Serious or rare side effects- Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions including rash, itching, hives, swelling of the face, lips, tongue, or throat, difficulty breathing;
• Bleeding problems (unusual bruising or bleeding, blood in the stool or urine, or vomiting blood);
• Eye problems (mild and transient blurred vision can be common, while new or worsening blurred vision or other visual disturbances warrant immediate medical attention);
• Increased blood pressure (your doctor should monitor your blood pressure);
• Low sodium levels (hyponatremia) (symptoms can include headache, confusion, weakness, muscle cramps, nausea, and vomiting);
• Liver damage (symptoms may include yellowing of the skin or eyes, dark urine, pale stools, and upper abdominal pain);
• Manic episodes (symptoms can include racing thoughts, increased energy, reckless behavior, and excessive happiness or irritability);
• Seizures;
• Serotonin syndrome (symptoms can include agitation, confusion, fast heartbeat, fever, muscle stiffness, twitching, nausea, vomiting, and diarrhea);
• Suicidal thoughts or actions (especially in children, teenagers, and young adults, or during the first few months of treatment or when the dose is changed)

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Cymbalta, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Cymbalta should not be used if:
• You are allergic to duloxetine or any of the inactive ingredients;
• You have hepatic impairment (in patients with any liver disease);
• You are taking MAO inhibitors (do not take Cymbalta if you are currently taking or have taken an MAOI within the past 14 days. Also, do not start an MAOI within 5 days of stopping Cymbalta. The 5-day waiting period is to wait after stopping Cymbalta to start an MAOI)
• You have severe renal impairment (Cymbalta is contraindicated in patients with severe renal impairment, defined as a creatinine clearance of less than 30 mL/min, or in patients with end-stage renal disease);
• You have uncontrolled narrow-angle glaucoma (Cymbalta may increase the risk of mydriasis, triggering an acute angle-closure glaucoma attack); • You are taking thioridazine (using Cymbalta with thioridazine can increase the risk of serious cardiac problems)

Tell your doctor about all of your medical conditions, past and present, before starting Cymbalta. This is crucial because certain conditions can affect whether Cymbalta is right for you. These conditions may include, but are not limited to:
• Bleeding disorders or concomitant use of anticoagulants or antiplatelet drugs (may increase the risk of bleeding)
• Diabetes (Cymbalta may affect blood sugar, monitoring may be necessary);
• Glaucoma (uncontrolled narrow-angle glaucoma is a contraindication, and that caution should be used for all other forms of glaucoma);
• Heart problems (use with caution if you have cardiovascular disease);
• History of mania or bipolar disorder (Cymbalta may induce a manic or hypomanic episode in susceptible individuals);
• Hypertension (high blood pressure - Cymbalta can increase your blood pressure, so it should be monitored regularly);
• Hyponatremia (low sodium levels- Cymbalta can cause or worsen low sodium levels);
• Seizure disorders (use with caution if you have a history of seizures);
• Urinary retention (Cymbalta may urination)

Drug Interactions:

Before taking Cymbalta, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Patient Medication Information | Lilly: https://pi.lilly.com/ca/cymbalta-ca-pmi.pdf

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Cymbalta may interact with other medicines but is not limited to:
• Anticoagulants (blood thinners like warfarin, monitor closely for signs of bleeding);
• Amphetamines (may increase the risk of serotonin syndrome and cardiovascular effects);
• Buspirone (may increase the risk of serotonin syndrome);
• Cimetidine (can increase duloxetine levels);
• CYP1A2 inhibitors (such as fluvoxamine and ciprofloxacin can increase duloxetine levels);
• CYP2D6 inhibitors (such as paroxetine, fluoxetine, quinidine, and thioridazine, can increase duloxetine levels);
• Lithium (may increase the risk of side effects);
• NSAIDs & Aspirin (may increase the risk of bleeding);
• Other serotonergic antidepressants (use with caution if you are taking SSRIs, SNRIs, TCAs, trazodone, and bupropion - due to an increased risk of serotonin syndrome);
• St. John's Wort (this herbal supplement can also raise serotonin levels);
• Tramadol (affects serotonin and increases the risk)

Alcohol:
Combining Cymbalta with excessive alcohol consumption may increase the risk of liver damage. Cymbalta should not be used by individuals who regularly consume excessive amounts of alcohol. You should avoid or limit alcohol intake while taking Cymbalta to minimize the potential risk of liver issues. Alcohol can also worsen symptoms of depression and anxiety, which Cymbalta is often used to treat.

Elderly Patients:
Elderly patients may be more susceptible to certain side effects, such as falls due to dizziness and orthostatic hypotension. Avoid driving, operating machinery, or engaging in activities that require alertness until you understand how it affects you.

Pregnancy and Breastfeeding:

You must consult the risks and benefits with your doctor. Cymbalta may have potential risks to the fetus, especially in later pregnancy, and it passes into breast milk.

Frequently Asked Questions about Cymbalta at Canada Pharmacy Online:

Why is Cymbalta more affordable in Canada than in the United States?

Prescription drug prices, including Cymbalta, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can the Cymbalta pill be split or crushed?

Do not crush, chew, or split Cymbalta capsules. Swallow the capsule whole with water. Crushing, chewing, or splitting the capsules may affect how the medication is released and absorbed in the body. Consult your doctor or pharmacist if you have difficulty swallowing the capsule.

What is the difference between Cymbalta 30 mg and 60 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many capsules I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Cymbalta at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Cymbalta requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Cymbalta?

Yes, there is a generic alternative for this product called duloxetine.

How long does it take for Cymbalta to work?

You may start to see some improvement in your mood or anxiety symptoms within 1 to 4 weeks. For nerve pain, fibromyalgia, or chronic musculoskeletal pain, it may take several weeks to notice a significant reduction in pain. It's important to continue taking Cymbalta as prescribed, even if you don't feel better right away, and to discuss your progress with your doctor.

Can I stop taking Cymbalta suddenly?

No, you should not stop taking Cymbalta suddenly. Abrupt discontinuation can lead to withdrawal symptoms, which may include dizziness, nausea, headache, sensory disturbances (like "brain zaps"), anxiety, and irritability. Your doctor will provide instructions for gradually tapering off the medication to minimize these effects.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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