Anafranil (Clomipramine)

Name: Anafranil
Brand: Apotex
SKU: 0092
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Anafranil Tablet

Manufacturer: Apotex

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Anafranil

Manufacturer: Teofarma Pharma

Country: Turkey

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Anafranil Tablet

Manufacturer: Apotex

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Anafranil Tablet

Manufacturer: Apotex

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Anafranil Extended Release Tablets

Manufacturer: Teofarma Pharma

Country: Turkey

Dosage: 75 mg

Qty-Price (USD):

Generic Equivalent of Anafranil

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Clomipramine

Manufacturer: Generic

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Clomipramine

Manufacturer: Generic

Country: United Kingdom

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Clomipramine (Clofranil - Sun Pharma)

Manufacturer: Generic

Country: India

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Clomipramine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Clomipramine

Manufacturer: Generic

Country: India

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Clomipramine Capsule

Manufacturer: Generic

Country: Canada

Dosage: 50 mg

Qty-Price (USD):

Type:

Product: Clomipramine SR (ON BACKORDER)

Manufacturer: Generic

Country: India

Dosage: 75 mg

Qty-Price (USD):

Anafranil Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on July 22, 2025.

Anafranil and Clomipramine at CanadaPharmacyOnline.com

The brand Anafranil (clomipramine hydrochloride) is manufactured and marketed by Apotex Inc. in Canada. It is also manufactured by Teofarma Pharma in Turkey.

Generic clomipramine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Anafranil:

Generic clomipramine contains the same active ingredient as the brand-name Anafranil and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it is designed to work in the same way as clomipramine, also known as Anafranil. Studies have demonstrated bioequivalence between generic and brand-name clomipramine, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic clomipramine, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Anafranil (clomipramine hydrochloride) is available in oral tablets of 10 mg, 25 mg, and 50 mg.

Generic clomipramine is also commonly available in these strengths, often as oral capsules. Additionally, clomipramine is available in a 75 mg extended-release tablet formulation.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Anafranil (clomipramine) is a prescription medication used to treat various psychiatric conditions by affecting certain natural substances in the brain. Common uses include:
• Depression: Treatment of major depressive disorder. It may also have a mild sedative effect that can help alleviate anxiety, which is often accompanied by depression.
• Obsessive-Compulsive Disorder (OCD): Treatment of obsessions and compulsions that cause marked distress, are time-consuming, or significantly interfere with social or occupational functioning. Anafranil was the first FDA-approved medication for OCD.
• Other Off-Label Uses: Sometimes used off-label for conditions such as panic disorder, chronic pain, cataplexy associated with narcolepsy, trichotillomania (hair-pulling disorder), and premature ejaculation.

Mechanism of Action
Anafranil (clomipramine) is a tricyclic antidepressant that primarily influences its therapeutic effects through potent inhibition of the reuptake of serotonin (5-HT) into central nerve terminals. It also weakly inhibits the reuptake of norepinephrine. By blocking the reuptake of these neurotransmitters, clomipramine increases their concentration at receptor sites in the brain, thereby influencing mood and behavior. Clomipramine also has some antihistamine and anticholinergic properties.

Take Anafranil exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Anafranil, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Anafranil, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Anafranil; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Blurred vision
• Changes in appetite/weight
• Constipation
• Decreased sexual desire
• Dizziness
• Drowsiness
• Dry mouth
• Fatigue/Tiredness
• Headache
• Impotence (in men)
• Increased light sensitivity
• Nausea
• Nervousness
• Problems with ejaculation (in men)
• Sweating
• Tremor
• Urination problems
• Vomiting

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.
• Cardiovascular effects: Arrhythmias (irregular heartbeat, including QT prolongation, Torsades de pointes), fast heartbeat, chest pain, hypotension (low blood pressure), fainting, heart failure, cardiac arrest.
• Liver problems: Symptoms like yellowing of the skin or eyes (jaundice), dark urine, persistent nausea or vomiting.
• Maniac or hypomanic episodes: Extreme increases in activity or talking, frenzied or abnormally excited mood.
• Neuroleptic Malignant Syndrome (NMS): A Rare but life-threatening reaction with symptoms like high fever, severe muscle stiffness, confusion, sweating, rapid heart rate, and blood pressure changes.
• Neurological effects: Convulsions/seizures, ataxia (loss of coordination), confusion, memory impairment, disorientation, hallucinations (particularly in elderly patients and those with Parkinson's disease), muscle twitching, muscle rigidity.
• Serotonin Syndrome: Agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, severe nausea/vomiting/diarrhea.
• Suicidal thoughts or behavior: Especially in children, adolescents, and young adults (up to 24 years of age), particularly at the beginning of treatment or with dose changes.
• Urinary retention: Trouble urinating.
• Vision changes: Eye pain/swelling/redness, widened pupils, seeing halos around lights, narrow-angle glaucoma.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Anafranil, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Anafranil should not be used if:
• You are allergic to clomipramine or any other tricyclic antidepressants (e.g., imipramine, amitriptyline, nortriptyline) or any other ingredient in Anafranil.
• You are in the acute recovery phase following a myocardial infarction (heart attack).
• You have acute congestive heart failure.
• You have existing severe liver or kidney damage.
• You have a history of blood dyscrasias.
• You have taken a monoamine oxidase inhibitor (MAOI) within the last 14 days (e.g., isocarboxazid, phenelzine, selegiline, tranylcypromine, linezolid, methylene blue injection). A dangerous drug interaction, including hyperpyretic crisis, seizures, coma, and death, can occur.
• You have untreated narrow-angle glaucoma.

Tell your doctor about all of your medical conditions, past and present, before starting Anafranil. This is crucial because certain conditions affect whether Anafranil is right for you. These conditions may include, but are not limited to:
• Alcoholism or sedative dependency
• Bipolar disorder (manic-depression)
• Blood pressure issues (low blood pressure or labile circulation)
• Cardiovascular disorders (e.g., heart failure, conduction disorders like AV block, arrhythmias)
• Conditions that may increase your risk of seizures (e.g., brain injury/disease, history of seizures, electroconvulsive therapy)
• Family history of specific heart problems (e.g., QT prolongation, sudden cardiac death)
• Gastrointestinal motility issues or urinary retention (e.g., enlarged prostate)
• Hyperthyroidism (overactive thyroid)
• Increased intraocular pressure
• Liver impairment
• Pheochromocytoma or neuroblastoma (adrenal gland tumor)
• Schizophrenia or other mental illnesses

Dizziness and Drowsiness:
Anafranil may cause dizziness, drowsiness, or blurred vision. Avoid driving, operating machinery, or engaging in activities that require alertness until you understand how it affects you.

Drug Interactions

Before taking Anafranil, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit Details for: ANAFRANIL | Drug and Health Products Portal at https://dhpp.hpfb-dgpsa.ca/dhpp/resource/2164.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Anafranil. Anafranil may interact with other medicines, but is not limited to:
• Anticholinergic drugs (e.g., atropine, certain antihistamines, antiparkinsonian medications): May increase the risk of anticholinergic side effects, including dry mouth, blurred vision, constipation, and urinary retention.
• Anticoagulants (blood thinners, e.g., warfarin): Tricyclic antidepressants can sometimes alter the effects of anticoagulants; close monitoring of INR may be advised.
• Antidepressants (SSRIs, SNRIs, other TCAs):
• SSRIs (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline): May increase clomipramine levels and the risk of side effects, including serotonin syndrome, due to inhibition of clomipramine metabolism.
• Other TCAs: Concomitant use with other tricyclic antidepressants is generally not recommended due to the increased risk of side effects.
• Antihypertensives (blood pressure medications): May cause additive hypotensive effects, particularly orthostatic hypotension.
• CNS Depressants (e.g., benzodiazepines, opioids, sedatives, hypnotics): May cause additive CNS depression, leading to increased drowsiness, dizziness, and impaired coordination.
• CYP2D6 inhibitors (e.g., quinidine, fluoxetine, paroxetine, thioridazine, propafenone): Can significantly increase clomipramine plasma concentrations and the risk of adverse effects.
• Monoamine Oxidase Inhibitors (MAOIs) (e.g., phenelzine, selegiline, isocarboxazid, tranylcypromine, linezolid, methylene blue injection): Contraindicated. Concomitant use or use within 14 days of discontinuing an MAOI can lead to severe, potentially fatal reactions (e.g., serotonin syndrome, hyperpyretic crisis, seizures, coma).
• QT-prolonging drugs (e.g., certain antiarrhythmics like quinidine, procainamide, amiodarone, sotalol; some antipsychotics like thioridazine; some antibiotics; certain antihistamines): May increase the risk of serious cardiac arrhythmias (QT prolongation).
• Stimulants (e.g., methylphenidate): May potentiate the effects of clomipramine.
• Sympathomimetics (e.g., epinephrine, norepinephrine, decongestants): May potentiate the cardiovascular effects of sympathomimetic agents.
• Thyroid hormones: May increase the risk of cardiac arrhythmias.

Anafranil may also interact with grapefruit, grapefruit juice, or grapefruit products. Avoid consuming grapefruit or products that contain grapefruit juice while using this medication.

Pregnancy and Breastfeeding

Anafranil is generally not recommended during pregnancy unless the potential benefit outweighs the potential risk to the fetus, as animal studies and human data have suggested an association with congenital heart defects and reversible withdrawal effects in the newborn. If you are pregnant or planning to become pregnant, discuss this with your doctor. Clomipramine is excreted into breast milk. Nursing while taking clomipramine is generally advised against due to potential risks to the infant. Consult your doctor for personalized advice.

Use in Children

Anafranil is indicated for the treatment of obsessive-compulsive disorder (OCD) in children and adolescents aged 10 years and older. The safety and effectiveness of OCD in children younger than 10 years have not been established. For depression, Health Canada has not authorized an indication for pediatric use in children under 18 years of age. In pediatric patients, the dosage is based on body weight, with careful titration and monitoring.

Use in Elderly

Elderly patients taking Anafranil should be monitored closely, especially for dizziness, orthostatic hypotension, confusion or impaired memory, and urinary retention, as they may be more susceptible to these side effects and have a potential increased risk of falls. Lower initial doses and careful titration are often recommended.

Frequently Asked Questions about Anafranil at Canada Pharmacy Online:

Why is Anafranil more affordable in Canada than in the United States?

Prescription drug prices, including Anafranil, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Anafranil at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Anafranil requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Anafranil?

Anafranil can be taken with or without food. To reduce stomach upset, it is recommended to take it with food, especially when first starting to use it. If taking once daily, it's often recommended to take it at bedtime to minimize daytime drowsiness. Your doctor will provide specific instructions on the timing of your dose.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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