Arthrotec (Diclofenac/Misoprostol)

Name: Arthrotec
Brand: Pfizer
SKU: 0110
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Arthrotec

Manufacturer: Pfizer

Country: Canada

Dosage: 50 mg/200 mcg

Qty-Price (USD):

Type:

Product: Arthrotec

Manufacturer: Pfizer

Country: Canada

Dosage: 75 mg/200 mcg

Qty-Price (USD):

Generic Equivalent of Arthrotec

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Diclofenac/Misoprostol (Expiry Note)

Manufacturer: Generic

Country: Canada

Dosage: 50 mg/200 mcg

Qty-Price (USD):

Type:

Product: Diclofenac/Misoprostol (Expiry Note)

Manufacturer: Generic

Country: Canada

Dosage: 75 mg/200 mcg

Qty-Price (USD):

Arthrotec Information

Arthrotec and Diclofenac/misoprostol at CanadaPharmacyOnline.com

The manufacturer of brand-name Arthrotec is Pfizer Inc. Arthrotec is a combination medication designed to provide powerful pain relief while protecting the stomach. In Canada, brand-name Arthrotec remains a standard treatment for chronic inflammatory conditions.

While the brand name is a trusted choice, generic diclofenac/misoprostol is produced by several manufacturers that meet Health Canada's strict safety and quality standards. Common generic producers in Canada include AA Pharma and Sandoz. Generic versions are sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Diclofenac/misoprostol

Generic diclofenac/misoprostol contains the same active ingredient as brand-name Arthrotec. It must meet the same effectiveness and quality standards. This means it is designed to work like Arthrotec. Studies have shown that generic diclofenac/misoprostol is bioequivalent to brand-name Arthrotec, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Arthrotec (diclofenac/misoprostol) is available in two specific combination strengths, typically provided as delayed-release tablets:
• Arthrotec 50: 50 mg diclofenac sodium and 200 mcg misoprostol.
• Arthrotec 75: 75 mg diclofenac sodium and 200 mcg misoprostol.

The standard adult dose is 1 tablet taken 3 to 4 times daily for Arthrotec 50, or 1 tablet twice daily for Arthrotec 75. Swallow the tablets whole. Do not crush or chew to preserve the protective coating.

Usage:

Arthrotec is used to treat the signs and symptoms of osteoarthritis and rheumatoid arthritis. It is specifically prescribed for patients who are at high risk of developing stomach ulcers or complications from traditional non-steroidal anti-inflammatory drugs (NSAIDs). By combining a pain reliever with a protective agent, Arthrotec enables effective arthritis management while reducing the risk of serious gastrointestinal complications. It is intended for daily use as directed by a doctor.

Mechanism of Action
Diclofenac and misoprostol, the active ingredients in Arthrotec, work together using a strike-and-shield approach to manage pain safely. The first ingredient, diclofenac, belongs to a group of medicines called NSAIDs. It works by blocking the production of natural chemicals (prostaglandins) that cause pain, fever, and joint inflammation. While NSAIDs are effective, they can reduce the natural protective lining of the stomach. The second ingredient, misoprostol, is a synthetic prostaglandin that replaces the protection lost. It works by decreasing the amount of acid your stomach produces and increasing the production of protective mucus and bicarbonate, helping to prevent ulcers from forming.

Take Arthrotec exactly as your doctor prescribes, according to the product monograph. It is best taken with food to further minimize stomach upset. Do not take antacids containing magnesium while taking Arthrotec, as they can worsen diarrhea.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Arthrotec, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Arthrotec (diclofenac/misoprostol). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Arthrotec; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain or diarrhea (common in the first few weeks)
• Dizziness
• Headache
• Nausea or gas

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Heart/circulation issues: Chest pain, shortness of breath, or sudden weakness on one side of the body.
• Liver problems: Yellowing of the eyes/skin or dark urine.
• Severe allergic reaction: Swelling of the face or throat and difficulty breathing.
• Signs of stomach bleeding: Black/tarry stools, coffee-ground vomit, or severe stomach pain.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Arthrotec, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Arthrotec/diclofenac/misoprostol if:
• Allergies: You have a known hypersensitivity to diclofenac, misoprostol, aspirin, or other NSAIDs.
• Pregnancy: Do not use Arthrotec if you are pregnant. The misoprostol component can cause severe congenital disabilities, premature birth, or uterine rupture and is used in other contexts to induce labor or abortion.

Tell your doctor about all of your medical conditions, past and present, before starting Arthrotec. This is crucial as certain conditions affect the drug's safety.
• History of asthma or allergies: If you have had a severe reaction to aspirin or other NSAIDs.
• Recent heart surgery: Specifically, before or after heart bypass surgery (CABG).
• Active bleeding: If you have an active stomach ulcer or intestinal bleeding.

Drug Interactions:

Before taking Arthrotec, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://labeling.pfizer.com/showlabeling.aspx?format=PDF&id=526.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Arthrotec. Arthrotec may interact with other medicines, including but not limited to:
• Blood thinners: Taking Arthrotec with blood thinners like warfarin can increase the risk of bleeding.
• Diuretics: Arthrotec may reduce the effectiveness of water pills used to treat high blood pressure.
• Other NSAIDs: Avoid taking with aspirin or ibuprofen unless directed by a doctor.

Pregnancy and Breastfeeding:

Arthrotec is not recommended during pregnancy. The misoprostol component is known to cause miscarriages, premature birth, and severe congenital disabilities. It can also cause the uterus to tear (uterine rupture) if taken during pregnancy. If you are a person of childbearing age, your doctor will likely require a negative pregnancy test within two weeks before starting treatment and will insist on the use of effective contraception throughout the duration of therapy. It is generally not recommended to breastfeed while taking Arthrotec. Diclofenac passes into breast milk in small amounts, and misoprostol could potentially cause diarrhea in a nursing infant.

Use in Children:

The safety and effectiveness of Arthrotec in children under 18 years of age have not been established. Because of the risks associated with both the potent anti-inflammatory (diclofenac) and the stomach-protecting agent (misoprostol), this combination is typically reserved for use in adults.

Frequently Asked Questions about Arthrotec at Canada Pharmacy Online

Why is Arthrotec more affordable in Canada than in the United States?

Prescription drug prices, including Arthrotec, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Arthrotec I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Arthrotec per prescription from your doctor.

Can I buy Arthrotec from you over the counter?

No, Arthrotec requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Arthrotec?

Yes, there is a generic alternative to Arthrotec: diclofenac/misoprostol.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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