Cubicin (Daptomycin)

Name: Cubicin
Brand: Sunovion
SKU: 7606
Availability: InStock

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Qty-Price (USD)

Type:

Product: Cubicin (CURRENTLY UNAVAILABLE)

Manufacturer: Sunovion

Country: Canada

Dosage: 500 mg/1 vials

Qty-Price (USD):

Generic Equivalent of Cubicin

Type

Product

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There is no generic product of Cubicin.

Cubicin Information

Cubicin at CanadaPharmacyOnline.com

The manufacturer of Cubicin in Canada is Sunovion Pharmaceuticals Canada Inc. It was originally developed by Eli Lilly and later brought to market by Cubist Pharmaceuticals (which was acquired by Merck & Co.). In the Canadian market, brand-name Cubicin and its updated formulation, Cubicin RF, are distributed via Sunovion.

The generic daptomycin is currently unavailable (at this pharmacy).

Dosage:

Cubicin is available in the following form and strengths:
• Powder for solution: 500 mg single-dose vials.

The medication is administered intravenously, either as an injection over 2 minutes or an infusion over 30 to 60 minutes. Pediatric doses (ages 1–17) are calculated by weight and age, ranging from 5 mg/kg to 12 mg/kg. Crucially, for children aged 1 to 6 years, the infusion must be administered over 60 minutes to ensure safety. For children aged 7–17, a 30-minute infusion is standard.

Usage:

Cubicin is a potent, injectable antibiotic used to treat complicated infections caused by Gram-positive bacteria, including superbugs, such as Methicillin-resistant Staphylococcus aureus (MRSA). It is primarily indicated for complicated skin and soft tissue infections (cSSSI) and bloodstream infections (bacteremia). In adults, it is also used for right-sided infective endocarditis, an infection of the heart's lining or valves. Unlike broad-spectrum antibiotics, Cubicin highly targets specific severe infections often contracted in hospital settings. It is important to note that Cubicin is not used to treat pneumonia, as it is deactivated by surfactant in the lungs. Because it is an antibiotic, it treats only bacterial infections. It is ineffective against viral illnesses such as the common cold or the flu.

Mechanism of Action
Daptomycin, the active agent in Cubicin, belongs to a unique class of antibiotics called lipopeptides. It works by targeting the bacterial cell membrane rather than the cell wall. In the presence of calcium, the daptomycin molecule binds to the bacterial membrane and inserts its lipid tail into it. Multiple daptomycin molecules then cluster together to form a pore or channel. This causes a rapid efflux of potassium ions from the cell, leading to membrane depolarisation. This loss of electrical potential halts the production of DNA, RNA, and proteins, leading to rapid bacterial cell death. Because this mechanism differs from that of other antibiotics such as penicillins or vancomycin, Cubicin often remains effective against bacteria that have developed resistance to other treatments.

Take Cubicin exactly as your doctor prescribes, following the instructions in the product monograph. A healthcare professional typically administers this medication in a hospital or clinic. Ensure you complete the full course of therapy to prevent the return of the infection or the development of resistance.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Cubicin, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Cubicin (daptomycin). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Cubicin; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or constipation
• Headache or dizziness
• Insomnia (trouble sleeping)
• Nausea or vomiting
• Redness or pain at the injection site

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, lips, or throat, and difficulty breathing.
• C. diff-associated Diarrhea: Severe, watery, or bloody diarrhea with fever and stomach cramps.
• Eosinophilic Pneumonia: New or worsening cough, fever, or trouble breathing.
• Muscle Problems (Myopathy): Unexplained muscle pain, tenderness, or weakness, often accompanied by dark-colored urine.
• Peripheral Neuropathy: Numbness, tingling, or burning sensations in the hands or feet.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Cubicin, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Cubicin/daptomycin if:
• Allergies: You have a known hypersensitivity to daptomycin or any other ingredients in the vial.

Tell your doctor about all of your medical conditions, past and present, before starting Cubicin. This is crucial as certain conditions affect the drug's safety.
• Kidney Disease: The dose may need to be adjusted to once every 48 hours if your kidney function is impaired.
• Muscle Disorders: Tell your doctor if you have a history of muscle problems or elevated creatine phosphokinase (CPK) levels.
• Severe Liver Problems: While generally safe for the liver, severe impairment requires close monitoring.

Drug Interactions:

Before taking Cubicin, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://www.merck.com/product/usa/pi_circulars/c/cubicin/cubicin_pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Cubicin. Cubicin may interact with other medicines, including but not limited to:
• Statins: Medications used to lower cholesterol (e.g., atorvastatin, simvastatin) can increase the risk of muscle damage. Your doctor may advise you to stop taking statins during Cubicin treatment.
• Tobramycin: Use with caution as it may interact with daptomycin.
• Warfarin: Cubicin can interfere with certain blood-clotting tests, potentially leading to inaccurate INR readings. This is a laboratory interaction; the medication interferes with the testing reagents, potentially leading to inaccurate reporting of blood-clotting levels.

Pregnancy and Breastfeeding:

Cubicin should be used during pregnancy only if the potential benefit justifies the risk to the fetus. Daptomycin is known to be excreted in human milk. Because of the potential for adverse effects in nursing infants, it is generally recommended to discontinue breastfeeding during treatment. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

Cubicin is approved for use in children aged 1 year and older. It is contraindicated in infants under 12 months due to the potential for serious muscular or nervous system side effects observed in animal studies.

Frequently Asked Questions about Cubicin at Canada Pharmacy Online

Why is Cubicin more affordable in Canada than in the United States?

Prescription drug prices, including Cubicin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Cubicin I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Cubicin per prescription from your doctor.

Can I buy Cubicin from you over the counter?

No, Cubicin requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Cubicin?

No, the generic daptomycin is currently unavailable (at this pharmacy).

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Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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