Dapsone (Dapsone)

Name: Dapsone
Brand: Link Healthcare
SKU: 6419
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Dapsone Tablet

Manufacturer: Link Healthcare

Country: New Zealand

Dosage: 25 mg

Qty-Price (USD):

Type:

Product: Dapsone Tablet

Manufacturer: GSK

Country: India

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Dapsone Tablet

Manufacturer: Marcan

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Generic Equivalent of Dapsone

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Dapsone.

Dapsone Information

medically reviewed by Carol Hou (BSc. Pharm) on May 7, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Dapsone at CanadaPharmacyOnline.com

Brand Dapsone is manufactured by Link Healthcare, GSK, and Marcan, and is available in New Zealand, India, and Canada.

Generic dapsone is currently unavailable (at this pharmacy).

Dosage:

Dapsone is sold in strengths of 25 mg and 100 mg oral tablets.

Your doctor will determine your safe and effective dosage based on your individual needs.

Usage:

Dapsone is a prescription medication used to treat infections and skin problems such as leprosy and dermatitis herpetiformis.

Mechanism of Action:
Dapsone is a prescription medication with a dual mechanism of action, involving both antimicrobial and anti-inflammatory properties. As an antibacterial agent, dapsone primarily works by inhibiting dihydropteroate synthase, an enzyme essential for bacterial synthesis of dihydrofolic acid, thereby preventing the growth of certain bacteria. In addition, it demonstrates anti-inflammatory effects, including inhibiting myeloperoxidase (MPO), reducing reactive oxygen species (ROS) production, and suppressing neutrophil-mediated inflammatory responses. Dapsone is used to treat various dermatologic conditions, including leprosy and dermatitis herpetiformis, and has off-label uses for autoimmune and bullous diseases.

It is crucial to take Dapsone exactly as your doctor prescribes and read the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

Side Effects:

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Dapsone it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Common Side effects – these are some frequently reported side effects of Dapsone, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or if you experience any other concerning symptoms.
• Nausea
• Vomiting
• Loss of appetite
• Abdominal pain
• Headache
• Dizziness
• Blurred vision
• Skin rash
• Itching
• Fatigue
• Insomnia
• Ringing in the ears (tinnitus)
• Increased sensitivity of the skin to sunlight
• Tiredness or weakness (hemolysis usually mild)
• Bluish discoloration of the lips, fingertips, or skin (due to changes in hemoglobin)

Serious or rare side effects - Stop taking Dapsone and seek immediate medical attention if you experience any of the following:
• Hemolytic anemia: This is a potentially serious condition where red blood cells are destroyed faster than they can be made, leading to fatigue, weakness, jaundice (yellowing of the skin and eyes), and dark urine. Individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency are at higher risk.
• Agranulocytosis: A severe and dangerous decrease in white blood cells (specifically neutrophils), which increases the risk of serious infections. Symptoms can include fever, chills, sore throat, and mouth ulcers.
• Methemoglobinemia: A condition where the iron in hemoglobin cannot effectively carry oxygen, leading to bluish discoloration of the skin and lips (cyanosis), shortness of breath, and fatigue.
• Dapsone hypersensitivity syndrome (DHS): A severe and potentially life-threatening reaction that typically occurs within the first few weeks of treatment. Symptoms can include fever, rash (which can be severe and involve blistering and peeling), lymphadenopathy (swollen lymph nodes), hepatitis (inflammation of the liver), and sometimes involvement of other organs like the kidneys and lungs.
• Peripheral neuropathy: Nerve damage that can cause numbness, tingling, pain, and weakness, especially in the hands and feet. This can sometimes be irreversible.
• Liver problems (hepatitis): Inflammation of the liver, which can cause jaundice, abdominal pain, nausea, and fatigue.
• Motor neuropathy: Weakness of muscles.
• Sore throat
• Fever

Individual reactions can vary. It’s crucial to discuss potential side effects and risks with your doctor for a complete and up to date list.

Contraindications:

The following is not an exhaustive list of contraindications. It is crucial to discuss all of your medical conditions, past and present, and all the medications you are taking with your doctor or pharmacist before taking Dapsone.

Dapsone is CONTRAINDICATED in the following and should not be used if:
• Hypersensitivity to dapsone or any of its excipients: Dapsone should not be used in patients with a known allergy or hypersensitivity to the drug or any of the inactive ingredients in the formulation. Allergic reactions can range from mild skin rashes to severe, life-threatening reactions like Dapsone Hypersensitivity Syndrome.
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency: Dapsone can cause hemolytic anemia (destruction of red blood cells), and this risk is significantly increased in individuals with G6PD deficiency. Therefore, dapsone is generally contraindicated in patients with G6PD deficiency due to the high risk of severe hemolysis.

Tell your doctor about all your medical conditions, past and present, before starting Dapsone. This is crucial because certain conditions can affect whether Dapsone is right for you. These conditions may include but are not limited to:
• Severe anemia: Dapsone can exacerbate anemia due to its potential to cause hemolysis.
• Significant liver disease: Dapsone is metabolized by the liver, and impaired liver function may affect drug clearance and increase the risk of adverse effects.
• Significant kidney disease: Dapsone is also partly excreted by the kidneys, and severe renal impairment may lead to drug accumulation.

Drug Interactions:

Before taking Dapsone, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information refer to Dapsone Drug Information | MedlinePlus.gov

Drugs that may increase the risk of dapsone toxicity:
o Probenecid: Can inhibit the renal excretion of dapsone, leading to increased dapsone levels and a higher risk of adverse effects, particularly methemoglobinemia.
o Trimethoprim: Can increase serum levels of both drugs and potentially increase the risk of methemoglobinemia.
o Pyrimethamine: Similar to trimethoprim, may increase the risk of hematologic toxicity, including methemoglobinemia and bone marrow suppression.

Drugs that may decrease the efficacy of dapsone:
o Rifampicin: Can induce hepatic enzymes that metabolize dapsone, potentially leading to lower dapsone concentrations and reduced efficacy, especially in the treatment of leprosy. Dosage adjustments of dapsone may be necessary when used concurrently with rifampicin.

Drugs whose effects may be altered by dapsone:
o Didanosine (ddI): Dapsone can increase the risk of peripheral neuropathy.

Other potential interactions:
Drugs that can cause hemolysis: Concurrent use with other drugs that can cause hemolysis (e.g., primaquine, quinidine) may increase the risk of this adverse effect, especially in individuals with G6PD deficiency.

Drugs that can cause methemoglobinemia: Using dapsone with other drugs that can induce methemoglobinemia (e.g., nitrites, some local anaesthetics) may increase the risk of this condition.

Important Considerations:
Individuals with G6PD deficiency: Drug interactions that increase the risk of hemolysis are particularly important to consider in patients with G6PD deficiency, as they are already at higher risk of this adverse effect.

Monitoring: When dapsone is used in combination with other medications, close monitoring for potential drug interactions and adverse effects is essential. Dosage adjustments of dapsone or the co-administered drugs may be necessary.

Pregnancy and Breastfeeding:

While dapsone may be used in pregnancy and breastfeeding in certain circumstances, the potential risks and benefits should be carefully evaluated by a healthcare provider. Dapsone crosses the placenta and is excreted in breast milk, and there are potential risks to the fetus and nursing infant, including hemolysis, especially if the infant has G6PD deficiency.

Frequently Asked Questions about Dapsone at Canada Pharmacy Online:

Why is Dapsone more affordable in Canada than in the United States?

Prescription drug prices, including Dapsone, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on getting you the lowest prices on high quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Dapsone tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Dapsone at one time, as per your doctor’s prescription.

Can I buy Dapsone over the counter from you?

No, Dapsone requires a prescription from your doctor. We are unable to sell this product without a valid prescription from your doctor.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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