Declomycin (Demeclocycline)

Name: Declomycin
Brand: Generic
SKU: 7443
Availability: InStock

Type

Product

Manufacturer

Country

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Qty-Price (USD)

There is no brand product of Declomycin.

Generic Equivalent of Declomycin

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Demeclocycline Capsule

Manufacturer: Generic

Country: United Kingdom

Dosage: 150 mg

Qty-Price (USD):

Declomycin Information

Demeclocycline at CanadaPharmacyOnline.com

The manufacturer of Declomycin has changed over time as the product has transitioned between different pharmaceutical owners. Originally developed and marketed by Lederle (a division of Cyanamid), the brand was later acquired by Pfizer. In recent years, brand-name Declomycin has been largely discontinued in the United States and Canada (with status changes in Canada occurring between 1997 and 2007). The brand Declomycin is currently unavailable (at this pharmacy).

Generic demeclocycline is produced by specialized pharmaceutical firms that meet strict regulatory standards for efficacy and safety. In the United Kingdom, for example, it is manufactured by Mercury Pharmaceuticals Ltd. Generic demeclocycline is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Demeclocycline

Generic demeclocycline contains the same active ingredient as brand-name Declomycin. It must meet the same effectiveness and quality standards. This means it is designed to work like Declomycin. Studies have shown that generic demeclocycline is bioequivalent to brand-name Declomycin, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Demeclocycline is typically available in the following oral strengths and forms:
• Capsules: 150 mg.

For bacterial infections, the standard adult dose is 150 mg four times daily. When used for hormone-related conditions such as SIADH, the dose is often higher, ranging from 600 to 1200 mg daily in divided doses, depending on the patient's sodium levels.

Usage:

Declomycin is a tetracycline antibiotic with a dual role in medicine. It is primarily used to treat a wide range of bacterial infections, including respiratory tract infections like pneumonia, urinary tract infections, and certain skin or eye infections. It is also effective against diseases spread by ticks and lice, such as Rocky Mountain spotted fever. However, Declomycin has found a unique and significant off-label use in treating Syndrome of Inappropriate Antidiuretic Hormone (SIADH). In this condition, the body produces excess antidiuretic hormone, leading to water retention and dangerously low sodium levels (hyponatremia). Declomycin helps correct this balance by encouraging the kidneys to release excess water. Because it is an antibiotic, it will not work for viral infections like the common cold or flu.

Mechanism of Action
Demeclocycline works through two distinct biological pathways depending on the condition being treated. As an antibiotic, it is primarily bacteriostatic, meaning it stops bacteria from growing rather than killing them outright. It achieves this by binding to the 30S ribosomal subunit of bacteria, preventing the attachment of aminoacyl-tRNA and halting the production of essential proteins. Without these proteins, the bacteria cannot replicate. In its role for SIADH, the drug acts as an aquaretic. It interferes with the intracellular signalling of antidiuretic hormone (ADH) in the renal tubules. By blocking ADH action, it induces a mild state of nephrogenic diabetes insipidus, increasing the clearance of free water from the body and helping restore normal sodium concentrations in the blood.

Take Declomycin exactly as your doctor prescribes. For maximum effectiveness, it should be taken on an empty stomach, at least 1 hour before or 2 hours after meals, with a full glass of water. Avoid lying down for at least 30 minutes after taking a dose to prevent esophageal irritation.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Declomycin, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Declomycin (demeclocycline). It is not an exhaustive list, and individual reactions can vary.

Common side effects: Declomycin may cause these side effects; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Dizziness or headache
• Loss of appetite
• Nausea, vomiting, or diarrhea
• Sensitivity to sunlight (photosensitivity)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat and difficulty breathing.
• C. diff-associated Diarrhea: Severe, watery, or bloody diarrhea with fever.
• Intracranial Hypertension: Severe headache, vision changes, or ringing in the ears.
• Nephrotoxicity: Signs of kidney problems, such as changes in the amount of urine or severe thirst (diabetes insipidus symptoms).
• Tooth Discolouration: Permanent yellowing or browning of the teeth (primarily a risk in children under 8).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Declomycin, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Declomycin/demeclocycline if:
• Allergies: You have a known hypersensitivity to any tetracycline antibiotic.
• Severe Kidney or Liver Disease: The drug can worsen renal and hepatic function in these patients.

Tell your doctor about all of your medical conditions, past and present, before starting Declomycin. This is crucial as certain conditions affect the drug's safety.
• Myasthenia Gravis: Use with caution as it may cause muscle weakness.
• Systemic Lupus Erythematosus (SLE): Tetracyclines can cause a flare-up of this condition.

Drug Interactions:

Before taking Declomycin, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the drug information site at https://www.webmd.com/drugs/demeclocycline-declomycin.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Declomycin. Declomycin may interact with other medicines, including but not limited to:
• Antacids and Dairy: Products containing aluminum, magnesium, calcium (including milk), or iron can block the absorption of the drug. Take Declomycin 2 hours before or after these items.
• Birth Control: It may decrease the effectiveness of hormonal contraceptives.
• Penicillins: Tetracyclines may interfere with the bacteria-killing action of penicillin.
• Retinoids: Taking Declomycin with medications like isotretinoin (Accutane) increases the risk of pressure buildup in the brain.

Pregnancy and Breastfeeding:

Declomycin is contraindicated during pregnancy, particularly in the last half, as it can cause permanent discolouration of the baby's teeth and interfere with bone development. It also passes into breast milk. Therefore, breastfeeding is generally discouraged while taking this medication. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

Except in rare, life-threatening cases where no other antibiotic is suitable, Declomycin is avoided in children under 8 years of age.

Frequently Asked Questions about Declomycin at Canada Pharmacy Online

Why is Declomycin more affordable in Canada than in the United States?

Prescription drug prices, including Declomycin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Declomycin I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Declomycin per prescription from your doctor.

Can I buy Declomycin from you over the counter?

No, Declomycin requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Declomycin?

Yes, there is a generic alternative to Declomycin: demeclocycline.

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Latest News:

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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