Evista (Raloxifene)

Name: Evista
Brand: Eli Lilly
SKU: 0452
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Evista

Manufacturer: Eli Lilly

Country: Canada

Dosage: 60 mg

Qty-Price (USD):

Generic Equivalent of Evista

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Raloxifene

Manufacturer: Generic

Country: Canada

Dosage: 60 mg

Qty-Price (USD):

Type:

Product: Raloxifene

Manufacturer: Generic

Country: United Kingdom

Dosage: 60 mg

Qty-Price (USD):

Evista Information

medically reviewed by Carol Hou (BSc. Pharm) on September 4, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Evista and Raloxifene at CanadaPharmacyOnline.com

Eli Lilly manufactures the brand Evista in various countries, including Canada.

Generic raloxifene is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Evista:

Generic raloxifene contains the same active ingredient as the brand-name Evista and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it's designed to work in the same way as raloxifene, also known as Evista. Studies have demonstrated bioequivalence between generic and brand-name raloxifene, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic raloxifene, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Evista and its generic equivalent, raloxifene, are available as a 60 mg oral tablet.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Evista (raloxifene) is a prescription medication primarily used for estrogen-related conditions in postmenopausal women. It is not indicated for use in premenopausal women.

Uses:
• Prevention and Treatment of Osteoporosis: Evista is used to prevent and treat osteoporosis in postmenopausal women.
• Reduction of Invasive Breast Cancer Risk: It is also indicated to reduce the risk of invasive breast cancer in postmenopausal women who either have osteoporosis or are at a high risk for the disease.

Mechanism of Action
Raloxifene belongs to a class of drugs known as Selective Estrogen Receptor Modulators (SERMs). It works by selectively interacting with estrogen receptors throughout the body.
• In bone tissue, raloxifene acts like estrogen, helping to slow down bone breakdown and maintain or increase bone mineral density. This action helps to reduce the risk of fractures.
• In breast and uterine tissues, it acts as an anti-estrogen, blocking the effects of estrogen. This selective action helps to reduce the risk of invasive breast cancer without stimulating the growth of the breast and uterine lining.

Always take Evista exactly as your doctor prescribes. It is crucial to follow the instructions in the Details for Evista | Drug and Health Products Portal. Additionally, to support bone health, it is often recommended to take calcium and vitamin D supplements, as directed by your doctor, while taking this medication.

Consult your healthcare provider for personalized guidance and to ensure safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Evista, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Evista, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Evista; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Flu-like symptoms
• Hot flashes
• Joint pain
• Leg cramps
• Swelling of the hands, ankles, or feet

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing.
• Unusual Vaginal Bleeding: Any unexplained or abnormal vaginal bleeding should be reported to your doctor immediately.
Evista (raloxifene) carries a boxed warning due to an increased risk of severe, life-threatening events.
• Stroke: There is an increased risk of fatal stroke in postmenopausal women with a history of coronary heart disease or who are at increased risk for major coronary events.
o Symptoms include: sudden numbness or weakness, trouble speaking, confusion, or a sudden, severe headache.
• Venous Thromboembolic Events (VTEs): There is an increased risk of developing blood clots, including deep vein thrombosis (DVT) and pulmonary embolism (PE). The risk is highest during the first four months of treatment.
o Symptoms include: sudden chest pain, shortness of breath, or coughing up blood (PE); or swelling, warmth, or pain in the leg (DVT).

Contraindications

The following is not an exhaustive list of contraindications. Before starting Evista, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do NOT use Evista if you have any of the following conditions. These are considered absolute contraindications due to the high risk of severe adverse effects.
• A history of venous thromboembolic events (VTEs), including deep vein thrombosis (DVT), pulmonary embolism (PE), or retinal vein thrombosis.
• A known allergy to raloxifene or any of the ingredients in the medication.
• Active or a recent history of arterial thromboembolic events, such as stroke or a mini-stroke (TIA).
• Liver dysfunction or active liver disease.
• You are a premenopausal woman.
• You are pregnant, could become pregnant, or are breastfeeding.

Tell your doctor about all of your medical conditions, past and present, before starting Evista. This is crucial because certain conditions affect whether Evista is right for you. These conditions may include, but are not limited to:
• A history of breast cancer or breast lumps (regular mammograms are still required, as raloxifene is not a treatment for existing cancer).
• A history of heart disease, especially coronary artery disease.
• A history of high cholesterol, particularly high triglycerides.
• Immobilization: You must stop taking Evista at least 72 hours (3 days) before and during any period of prolonged immobilization, such as post-surgical recovery or long bed rest. Therapy should only be resumed after you are fully mobile.
• Kidney disease.
• Smoking: Smoking significantly increases the risk of blood clots and stroke. This risk-benefit balance must be carefully considered in women who smoke.

Drug Interactions

Before taking Evista, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information from Eli Lilly at https://pi.lilly.com/us/evista-pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Evista may interact with other medicines, but is not limited to:
• Cholestyramine: This medication can significantly reduce the absorption of raloxifene, which may make Evista less effective. Co-administration is generally not recommended.
• Highly Protein-Bound Drugs: Raloxifene is highly protein-bound in the blood. When used with other highly protein-bound drugs (such as diazepam, diazoxide, or lidocaine), a potential interaction may occur, affecting the levels of one or both drugs.
• Systemic Estrogens: The safety and effectiveness of using Evista in combination with other forms of estrogen (e.g., hormone replacement therapy) have not been established. This combination is generally not recommended.
• Warfarin or Other Blood Thinners: Evista can affect certain blood-clotting factors. When used in conjunction with anticoagulants, blood-thinning levels should be monitored more closely to ensure safety and effectiveness.

Pregnancy and Breastfeeding

Evista is contraindicated for use in women who are or may become pregnant. If you become pregnant while taking Evista, you should contact your doctor immediately. Based on its mechanism of action, raloxifene could cause fetal harm.

It is not known whether raloxifene is excreted in human milk. However, due to the potential for serious adverse effects in a nursing infant, Evista is contraindicated for use in breastfeeding women.

Use in the Elderly

While no specific dose adjustment is necessary for Evista (raloxifene) in elderly patients, the medication should be used with caution in this population. This is because older individuals, especially those over 60, have an increased baseline risk of venous thromboembolic events (VTEs) and stroke. Given that Evista itself carries a boxed warning for these same risks, healthcare providers must carefully consider the risk-benefit balance before prescribing the medication to an elderly patient.

Use in Children

The safety and efficacy of Evista (raloxifene) have not been established in the pediatric population, and therefore, it is not indicated for use in children.

Frequently Asked Questions about Evista at Canada Pharmacy Online:

Why is Evista more affordable in Canada than in the United States?

Prescription drug prices, including Evista, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Evista at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Evista requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Blog Posts:

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Latest News:

Why women over 30 are at higher risk of bone loss and osteoporosis; know the risks and ways to prevent (article published on September 4, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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