Factive (Gemifloxacin Mesylate)

Name: Factive
Brand: Brand
SKU: 6449
Availability: InStock

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Type:

Product: Factive

Manufacturer: Brand

Country: Turkey

Dosage: 320 mg

Qty-Price (USD):

Generic Equivalent of Factive

Type

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There is no generic product of Factive.

Factive Information

Factive at CanadaPharmacyOnline.com

The manufacturer of Factive is LG Chem Ltd. (formerly LG Life Sciences), based in the Republic of Korea. While LG Chem developed the drug, it has been distributed in Canada through regional partners such as Merus Labs International Inc. In the United States, Factive has been discontinued and is no longer available as of late 2022.

The generic gemifloxacin mesylate is currently unavailable (at this pharmacy).

Dosage:

Factive is available in the following strengths and forms:
• Oral Tablets: 320 mg (white to off-white, oval, film-coated tablets).

The recommended dose is one 320 mg tablet daily, taken for 5 to 7 days depending on the infection. You can take it with or without food and should swallow it whole with a liberal amount of liquid.

Usage:

Factive is a fluoroquinolone antibiotic used to treat bacterial lung infections in adults. It is primarily indicated for Acute Bacterial Exacerbation of Chronic Bronchitis (ABECB), where it is typically used for a short 5-day course. It is also highly effective for Community-Acquired Pneumonia (CAP) of mild to moderate severity, particularly cases caused by multidrug-resistant Streptococcus pneumoniae (MDRSP). Because it is a respiratory quinolone, Factive penetrates deeply into lung tissue and bronchial fluids. Like all antibiotics, Factive is only effective against bacterial infections. It will not treat viral illnesses such as the common cold, flu, or COVID-19. Complete the full course of therapy, even if you feel better, to prevent the infection from returning.

Mechanism of Action
Factive acts as a bactericidal agent by disrupting the essential machinery that bacteria use to replicate their genetic material. It targets two specific enzymes: DNA gyrase and topoisomerase IV. These enzymes are responsible for managing the supercoiling and separation of bacterial DNA during cell division. By binding to these targets, gemifloxacin prevents bacteria from unzipping their DNA during replication and from newly synthesized DNA separating into daughter cells. This leads to irreversible DNA damage and rapid bacterial cell death. Factive is considered dual-targeting because it inhibits both enzymes at therapeutically relevant levels, thereby significantly slowing the rate at which bacteria can develop resistance compared to single-target antibiotics.

Take Factive exactly as your doctor prescribes, following the instructions in the product monograph. Do not exceed the recommended dose or duration of treatment.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Factive, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Factive (gemifloxacin mesylate). It is not an exhaustive list, and individual reactions can vary.
Common side effects: These are common side effects of Factive; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or nausea
• Headache or dizziness
• Rash (more common in women under 40 and with longer treatment)
• Stomach pain or upset stomach

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face/throat and difficulty breathing.
• Central Nervous System Effects: Seizures, hallucinations, confusion, depression, or suicidal thoughts.
• Heart Rhythm Changes: Fast, pounding, or irregular heartbeat (QT prolongation).
• Liver Problems: Yellowing of the eyes/skin (jaundice), dark urine, or upper stomach pain.
• Peripheral Neuropathy: Pain, burning, tingling, numbness, or weakness in the arms or legs.
• Tendon Rupture/Tendinitis: Sudden pain, swelling, or a "pop" in a tendon (e.g., Achilles, shoulder, or hand).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Factive, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Factive/gemifloxacin mesylate if:
• Allergies: You have a known hypersensitivity to gemifloxacin or other fluoroquinolones (like Cipro or Levaquin).
• Myasthenia Gravis: Factive may exacerbate muscle weakness in patients with this condition.
• QT Prolongation: You have a history of prolonged QT interval or are taking heart rhythm medications.

Tell your doctor about all of your medical conditions, past and present, before starting Factive. This is crucial as certain conditions affect the drug's safety.
• Diabetes: This medication may cause changes in blood sugar (hypoglycemia).
• Kidney Disease: You may need a reduced dose (160 mg daily) if your creatinine clearance is <= 40 mL/min.
• Seizure History: Use with caution as fluoroquinolones can trigger CNS events.

Drug Interactions:

Before taking Factive, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the manufacturer's site at http://www.factive.com/factive/healthcare/healthcare_dosing-and-administration.jsp.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Factive. Factive may interact with other medicines, including but not limited to:
• Antacids and Supplements: Products containing aluminum, magnesium, iron, or zinc can block absorption. Take Factive 2 hours before or 3 hours after these products.
• Blood Thinners: May increase warfarin's effects, increasing the risk of bleeding.
• Probenecid: Increases the levels of Factive in your blood.
• Steroids: Increases the risk of tendon rupture.

Pregnancy and Breastfeeding:

Avoid Factive during pregnancy due to potential risks to the baby's developing joints. It passes into breast milk in small amounts. While generally acceptable, monitor the infant for diarrhea or yeast infection. Inform your doctor if you are breastfeeding, planning to become pregnant, or breastfeeding.

Use in Children:

The safety and effectiveness of Factive in patients under 18 years of age have not been established. Use in children is generally avoided.

Frequently Asked Questions about Factive at Canada Pharmacy Online

Why is Factive more affordable in Canada than in the United States?

Prescription drug prices, including Factive, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Factive I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Factive per prescription from your doctor.

Can I buy Factive from you over the counter?

No, Factive requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Factive?

No, the generic gemifloxacin mesylate is unavailable (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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