Lotrel (Amlodipine/Benazepril)

Name: Lotrel
Brand: Generic
SKU: 1625
Availability: InStock

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Product

Manufacturer

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Qty-Price (USD)

There is no brand product of Lotrel.

Generic Equivalent of Lotrel

Type

Product

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Type:

Product: Amlodipine/Benazepril Capsule

Manufacturer: Generic

Country: United States

Dosage: 5 mg/20 mg

Qty-Price (USD):

Type:

Product: Amlodipine/Benazepril Capsule

Manufacturer: Generic

Country: United States

Dosage: 5 mg/40 mg

Qty-Price (USD):

Type:

Product: Amlodipine/Benazepril Capsule

Manufacturer: Generic

Country: United States

Dosage: 10 mg/20 mg

Qty-Price (USD):

Type:

Product: Amlodipine/Benazepril Capsule

Manufacturer: Generic

Country: United States

Dosage: 10 mg/40 mg

Qty-Price (USD):

Lotrel Information

Amlodipine/Benazepril at CanadaPharmacyOnline.com

The manufacturer of brand-name Lotrel is Novartis Pharmaceuticals Corporation. The brand Lotrel is currently unavailable (at this pharmacy).

Generic amlodipine/benazepril capsules are manufactured in the United States by various manufacturers that meet FDA quality and safety standards. The specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Amlodipine/Benazepril

Generic amlodipine/benazepril contains the same active ingredients as brand-name Lotrel. It must meet the same effectiveness and quality standards. This means it is designed to work like Lotrel. Studies have shown that generic amlodipine/benazepril is bioequivalent to brand-name Lotrel, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Lotrel (amlodipine/benazepril) is available in the following oral strengths:
• Capsules: 5 mg/20 mg, 5 mg/40 mg, 10 mg/20 mg, and 10 mg/40 mg.

The dose is one capsule taken once daily, with or without food. Dosage should be adjusted according to your doctor's instructions.

Usage:

Lotrel is a combination blood pressure medication used to treat hypertension (high blood pressure) in patients not adequately controlled on monotherapy with either amlodipine or benazepril alone. Amlodipine is a calcium channel blocker, and benazepril is an angiotensin-converting enzyme (ACE) inhibitor. Together, they lower blood pressure through two complementary mechanisms. Lotrel is not recommended as initial (first-line) treatment for high blood pressure.

High blood pressure often has no symptoms, but if left untreated, it can lead to serious conditions such as a heart attack, stroke, and kidney damage. Controlling your blood pressure reduces these risks. Take Lotrel daily as directed by your doctor, even if you feel fine.

Mechanism of Action
Amlodipine works by relaxing the walls of blood vessels, allowing them to widen and making it easier for the heart to pump blood. Benazepril works by blocking an enzyme (ACE) that the body uses to produce angiotensin II, a hormone that tightens blood vessels. By blocking this enzyme, benazepril helps relax blood vessels and reduce fluid retention. Together, these two actions produce a greater reduction in blood pressure than either drug alone. An added benefit of combining the two drugs is that amlodipine-associated leg swelling (ankle edema) is significantly reduced with the addition of benazepril.

Take Lotrel exactly as your doctor prescribes, according to the highlights of prescribing information. Lotrel can be taken with or without food.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Lotrel, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Lotrel (amlodipine/benazepril). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Lotrel; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Cough (dry, persistent cough)
• Dizziness or headache
• Fatigue
• Flushing
• Nausea or stomach upset.
• Swelling of the ankles or feet (edema)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Angioedema (Severe Allergic Swelling): Swelling of the face, lips, tongue, or throat that may cause difficulty breathing or swallowing. This can occur at any time during treatment and requires immediate emergency care. Lotrel must not be restarted if you have experienced angioedema.
• High Potassium (Hyperkalemia): Muscle weakness, an irregular or slow heartbeat. The benazepril component can raise potassium levels, particularly in patients with kidney problems or those taking potassium supplements.
• Jaundice or Liver Problems: Yellowing of the skin or eyes, dark urine, or severe stomach pain.
• Low Blood Pressure (Hypotension): Severe dizziness or fainting, especially after the first dose or if you are dehydrated.
• Worsening Chest Pain or Heart Attack: Patients with coronary artery disease may experience increased angina or a heart attack when starting or increasing the amlodipine dose. Seek emergency care immediately if you have chest pain.
• Worsening Kidney Function: Decreased urine output or sudden swelling. ACE inhibitors can affect kidney function, especially in patients with pre-existing kidney or blood vessel conditions.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Lotrel, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Lotrel/amlodipine/benazepril if:
• Allergies: You have a known hypersensitivity to amlodipine, benazepril, any other ACE inhibitor, or any ingredient in the capsule.
• Angioedema History: You have a history of angioedema (swelling of the face or throat) related to previous ACE inhibitor therapy, or hereditary or idiopathic angioedema.
• Diabetes with Aliskiren: You are taking aliskiren (Rasilez) and have diabetes. ACE inhibitors must not be combined with aliskiren in patients with diabetes.
• Sacubitril/Valsartan (Entresto): Do not take Lotrel within 36 hours of switching to or from sacubitril/valsartan.
• Severe aortic stenosis

Tell your doctor about all of your medical conditions, past and present, before starting Lotrel. This is crucial as certain conditions affect the drug's safety.
• Congestive heart failure or a history of heart disease
• Diabetes
• Kidney or liver disease
• If you are on a low-sodium diet

Drug Interactions:

Before taking Lotrel, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the patient information leaflet at https://www.novartis.com/us-en/sites/novartis_us/files/lotrel_PPI.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Lotrel. Lotrel may interact with other medicines, including but not limited to:
• Aliskiren: Increases the risk of kidney failure, low blood pressure, and high potassium. Contraindicated in patients with diabetes.
• Diuretics (water pills): May cause an excessive drop in blood pressure, particularly with the first dose of Lotrel.
• NSAIDs (e.g., ibuprofen, naproxen): May reduce the blood pressure-lowering effect of Lotrel and can worsen kidney function.
• Other antihypertensive drugs: Additive blood pressure-lowering effects. Dose adjustments may be required.
• Potassium supplements or potassium-sparing diuretics (e.g., spironolactone): May raise potassium levels to dangerous levels when combined with benazepril.
• Simvastatin (Zocor): Amlodipine increases simvastatin concentrations in your blood, significantly increasing the risk of muscle pain and severe muscle breakdown (myopathy/rhabdomyolysis). Daily simvastatin doses should not exceed 20 mg when taken with Lotrel.

Pregnancy and Breastfeeding:

Lotrel can cause serious harm or death to an unborn baby, particularly if taken during the second or third trimester of pregnancy. Stop taking Lotrel as soon as you know you are pregnant and contact your doctor immediately. If you are planning to become pregnant, speak to your doctor before continuing treatment with Lotrel.

Amlodipine passes into breast milk. Benazepril has been detected at low levels in breast milk. Discuss the risks and benefits of breastfeeding with your doctor before taking Lotrel.

Use in Children:

Lotrel is approved for use in adults aged 18 years or older. The safety and efficacy of Lotrel in patients under 18 years of age have not been established. It should not be given to children.

Frequently Asked Questions about Lotrel at Canada Pharmacy Online

Why is Lotrel more affordable in Canada than in the United States?

Prescription drug prices, including Lotrel, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Lotrel capsules I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Lotrel per your doctor’s prescription.

Can I buy Lotrel from you over the counter?

No, Lotrel requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Lotrel?

Yes, the generic amlodipine/benazepril capsules are available.

Blog Post:

Hypertension: Don't Let the Silent Killer Lurk in Your Body

Latest News:

Antihypertensive treatment effect of amlodipine/benazepril versus benazepril/hydrochlorothiazide in patients with hypertension – Hypertension Research (published October 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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