Mycobutin (Rifabutin)

Name: Mycobutin
Brand: Pfizer
SKU: 1728
Availability: InStock

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Qty-Price (USD)

Type:

Product: Mycobutin (ON BACKORDER)

Manufacturer: Pfizer

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Mycobutin Capsule

Manufacturer: Pfizer

Country: Australia

Dosage: 150 mg

Qty-Price (USD):

Generic Equivalent of Mycobutin

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There is no generic product of Mycobutin.

Mycobutin Information

Mycobutin at CanadaPharmacyOnline.com

The manufacturer of Mycobutin (rifabutin) is Pfizer Inc., a global leader in pharmaceutical innovation. Rifabutin was developed as an effective alternative for patients who may not tolerate other rifamycin medications. In Canada, brand-name Mycobutin is marketed by Pfizer Canada ULC.

Generic rifabutin is currently unavailable (at this pharmacy)

Dosage:

Mycobutin is available in the following oral strengths and forms:
• Capsules: 150 mg.

For the prevention of MAC in adults, the standard dose is 300 mg once daily. For the treatment of active tuberculosis or other infections, the dosage is determined by a doctor or pharmacist. It is almost always taken in combination with other antimicrobial drugs.

Usage:

Mycobutin is a specialized antibiotic primarily used for the prevention of Mycobacterium avium complex (MAC) disease in patients with advanced HIV infection. It is also a vital component in combination therapy for the treatment of active tuberculosis (TB) and other mycobacterial infections. Because it belongs to the rifamycin family, it is often utilized when patients cannot tolerate rifampin or when a drug with fewer interactions is required. It is important to note that Mycobutin only treats bacterial infections; it will not work for viral illnesses like the common cold or the flu. Completing the full course of therapy is essential to ensure the bacteria are fully eradicated and to prevent the development of drug resistance.

Mechanism of Action

Rifabutin, the active agent in Mycobutin, works by aggressively disrupting the bacteria's genetic "blueprint" process. It is a potent inhibitor of DNA-dependent RNA polymerase, an enzyme essential for bacteria to transcribe their DNA into RNA. By binding to the beta-subunit of this enzyme, the medication physically blocks the production of RNA, preventing the bacteria from making the proteins they need to grow, repair themselves, and reproduce. This bactericidal (bacteria-killing) action is highly selective for mycobacteria. Interestingly, rifabutin also has a high degree of "tissue distribution," meaning it penetrates deeply into the body's cells and tissues where these specific bacteria often hide, making it highly effective for systemic infections.

Take Mycobutin exactly as your doctor prescribes, following the instructions in the product monograph. You can take this medication with food if it causes stomach upset, but it is important to take it consistently to maintain steady blood levels.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Mycobutin, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Mycobutin (rifabutin). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Mycobutin; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Discoloration of urine, sweat, saliva, and tears (typically a harmless orange-red color)
• Headache or muscle pain
• Nausea, vomiting, or stomach pain
• Skin rash

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat, and difficulty breathing.
• C. diff-associated Diarrhea: Severe, watery, or bloody diarrhea with stomach cramps.
• Liver Problems: Yellowing of the eyes or skin (jaundice), dark urine, or severe upper stomach pain.
• Neutropenia/Leukopenia: Signs of infection like fever, chills, or sore throat (indicating low white blood cell counts).
• Uveitis: Eye pain, redness, or blurred vision (inflammation of the eye).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Mycobutin, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Mycobutin/rifabutin if:
• Active Tuberculosis: It should not be used as a standalone treatment (monotherapy) for active TB, as this can lead to drug resistance.
• Allergies: You have a known hypersensitivity to rifabutin (e.g., rifampin or rifapentine).

Tell your doctor about all of your medical conditions, past and present, before starting Mycobutin. This is crucial as certain conditions affect the drug's safety.
• Blood Disorders: If you have a history of low white blood cell or platelet counts.
• Eye Issues: A history of uveitis or other inflammatory eye conditions.
• Liver or Kidney Disease: These organs process and clear the medication; you may require closer monitoring.

Drug Interactions:

Before taking Mycobutin, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the manufacturer’s site at https://labeling.pfizer.com/showlabeling.aspx?id=635.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Mycobutin. Mycobutin may interact with other medicines, including but not limited to:
• Antifungals, such as fluconazole or itraconazole, can increase Mycobutin levels in your blood.
• Antiretrovirals: Certain HIV medications (like protease inhibitors) can significantly interact with Mycobutin, requiring careful dose adjustments.
• Oral Contraceptives: Mycobutin may decrease the effectiveness of birth control pills. Discuss using a backup method.
• Warfarin: It may decrease the blood-thinning effect of warfarin, requiring more frequent monitoring.

Pregnancy and Breastfeeding:

Use Mycobutin in pregnancy only if the potential benefit justifies the risk to the fetus. There is limited data on its use in pregnant women. It is unknown if rifabutin passes into breast milk; however, because of the potential for adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or the drug.

Use in Children:

The safety and effectiveness of Mycobutin for the prevention of MAC in children have not been fully established. However, it has been used in pediatric patients under specialist guidance.

Frequently Asked Questions about Mycobutin at Canada Pharmacy Online

Why is Mycobutin more affordable in Canada than in the United States?

Prescription drug prices, including Mycobutin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Mycobutin I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Mycobutin per prescription from your doctor.

Can I buy Mycobutin from you over the counter?

No, Mycobutin requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Mycobutin?

No, the generic alternative is not available (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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