Olmetec Plus (Olmesartan/Hydrochlorothiazide)

Name: Olmetec Plus
Brand: Generic
SKU: 7362
Availability: InStock

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Manufacturer

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Qty-Price (USD)

There is no brand product of Olmetec Plus.

Generic Equivalent of Olmetec Plus

Type

Product

Manufacturer

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Type:

Product: Olmesartan/Hydrochlorothiazide Tablet

Manufacturer: Generic

Country: Canada

Dosage: 20 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Olmesartan/Hydrochlorothiazide Tablet

Manufacturer: Generic

Country: Canada

Dosage: 40 mg/12.5 mg

Qty-Price (USD):

Type:

Product: Olmesartan/Hydrochlorothiazide Tablet

Manufacturer: Generic

Country: Canada

Dosage: 40 mg/25 mg

Qty-Price (USD):

Olmetec Plus Information

Olmesartan/Hydrochlorothiazide at CanadaPharmacyOnline.com

Brand Olmetec Plus (olmesartan medoxomil and hydrochlorothiazide) was originally developed by Daiichi Sankyo and has been distributed in Canada under various entities. The current holder of the Canadian product monograph is Organon Canada Inc. (Kirkland, Québec). The brand-name Olmetec Plus is not currently available at this pharmacy.

Generic Olmesartan/Hydrochlorothiazide is available and is produced by several reputable pharmaceutical companies that meet the rigorous standards of Health Canada and the FDA. Generic Olmesartan/Hydrochlorothiazide is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Olmesartan/Hydrochlorothiazide:

Generic olmesartan medoxomil/hydrochlorothiazide tablets contain the same active ingredients as brand-name Olmetec Plus. They must meet the same effectiveness and quality standards set by Health Canada. Studies have shown that generic olmesartan/hydrochlorothiazide is bioequivalent to brand-name Olmetec Plus, meaning it has similar absorption and achieves comparable plasma concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Olmesartan medoxomil/hydrochlorothiazide is available in the following oral strengths and forms: Tablets: 20 mg/12.5 mg tablets, 40 mg/12.5 mg tablets, and 40 mg/25 mg film-coated tablets. The dose of Olmetec Plus is one tablet once daily. More than one tablet daily is not recommended. Olmetec Plus may be administered with or without food. Dosage should be individualized. Olmetec Plus is a fixed-dose combination and is not indicated for the initial starting therapy of hypertension.

Usage:

Olmetec Plus (olmesartan medoxomil and hydrochlorothiazide) is indicated for the treatment of mild to moderate essential hypertension in patients for whom combination therapy is appropriate. It is a fixed-dose combination product containing two antihypertensive drugs from different classes: an angiotensin II receptor blocker (ARB) and a thiazide diuretic. By combining these two drugs, Olmetec Plus provides additive blood pressure-lowering effects that are generally greater than either component alone. Olmetec Plus is appropriate for patients whose blood pressure has not been adequately controlled with olmesartan medoxomil (Olmetec) or hydrochlorothiazide alone.

Mechanism of Action
Olmetec Plus is a dual-action prescription medication that manages hypertension through two complementary pathways. It combines olmesartan medoxomil, an angiotensin II receptor blocker (ARB), with hydrochlorothiazide, a thiazide diuretic. By pairing these distinct therapies, Olmetec Plus achieves a synergistic effect, lowering blood pressure more effectively than either drug taken alone.

The first component, olmesartan medoxomil, is a prodrug that blocks angiotensin II from binding to its receptors. By preventing this hormone from causing blood vessel constriction and stimulating fluid-retaining aldosterone, olmesartan induces vasodilation (vessel relaxation) and reduces fluid volume, lowering blood pressure without affecting heart rate. The second component, hydrochlorothiazide, is a diuretic that inhibits the sodium-chloride co-transporter in the distal convoluted tubule of the kidney, forcing the body to excrete excess salt and water through urine. This reduction in blood volume decreases cardiac workload. At the same time, long-term use further lowers peripheral vascular resistance, thereby relaxing blood vessels.

Take Olmetec Plus exactly as your doctor prescribes, following the instructions in the product monograph. Olmetec Plus may be taken with or without food, once daily.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Olmetec Plus, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Olmetec Plus (olmesartan medoxomil/hydrochlorothiazide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Olmetec Plus; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abdominal pain or discomfort
• Back or leg pain
• Constipation
• Cough (uncommon; ARBs are significantly less likely to cause a persistent dry cough than ACE inhibitors)
• Decreased appetite
• Diarrhea
• Dizziness or light-headedness, particularly on standing (orthostatic hypotension)
• Fatigue
• Headache
• Heartburn or indigestion
• Nausea or vomiting
• Pins and needles sensation (paraesthesia)
• Sexual difficulties
• Skin reactions, including photosensitivity (increased sensitivity to sunlight, most common with hydrochlorothiazide)
• Upper respiratory tract infection

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Acute angle-closure glaucoma (Acute Myopia and Glaucoma): Sudden blurred vision, severe eye pain, or increased pressure in the eye.
• Anaphylaxis or severe allergic reaction: Hives, rash, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Chest pain or signs of myocardial ischemia: Excessive blood pressure lowering may precipitate ischemia in patients with coronary artery or cerebrovascular disease.
• Hyperkalemia (high potassium): Muscle weakness, fatigue, palpitations, or abnormal heart rhythm.
• Hypokalaemia (low potassium): Muscle cramps, weakness, irregular heartbeat, or extreme thirst and urination.
• Hypotension (severe): Marked dizziness, near-fainting, or fainting, particularly on standing or with the first doses. More likely in patients who are volume- or salt-depleted.
• Liver problems: Jaundice (yellowing of the skin or eyes), dark urine, or severe abdominal pain.
• Non-melanoma skin cancer: Inspect your skin regularly for new or changing lesions, and report any suspicious skin changes to your doctor. Protect your skin from sunlight and avoid indoor tanning.
• Renal failure: Decreased urine output, swelling, or signs of acute kidney injury.
• Severe skin reactions: Stevens-Johnson syndrome, toxic epidermal necrolysis, or widespread blistering or peeling of the skin.
• Sprue-like enteropathy (olmesartan-specific): Severe, chronic diarrhea with substantial weight loss, which can develop months to years after starting treatment.
• Systemic lupus erythematosus (SLE): Hydrochlorothiazide has been reported to exacerbate or activate systemic lupus erythematosus in susceptible patients.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Olmetec Plus, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Olmetec Plus/olmesartan medoxomil/hydrochlorothiazide if:
• Aliskiren (Rasilez) in patients with diabetes or moderate-to-severe renal impairment: The combination of Olmetec Plus with aliskiren-containing drugs is contraindicated in patients with diabetes mellitus or moderate-to-severe renal impairment due to an increased risk of hypotension, syncope, stroke, hyperkalemia, and deterioration of renal function.
• Allergies to sulfonamide-derived drugs: Olmetec Plus is contraindicated in patients with a known hypersensitivity to other sulfonamide-derived drugs (e.g., furosemide, certain sulfonylurea diabetes medications, certain antibiotics).
• Allergies: Known hypersensitivity to olmesartan medoxomil, hydrochlorothiazide, or any ingredient in the formulation.
• Anuria (inability to produce urine)
• Breastfeeding
• Pregnancy (or if you are planning to become pregnant, due to the risk of severe fetal injury or death)

Tell your doctor about all of your medical conditions, past and present, before starting Olmetec Plus. This is crucial as certain conditions affect the drug’s safety.
• Aortic or mitral valve stenosis
• Diabetes mellitus
• Gout or hyperuricemia
• Hypercalcemia (high blood calcium)
• Hypertrophic cardiomyopathy with outflow tract obstruction
• Liver disease (moderate to severe)
• Lupus erythematosus
• Personal or family history of skin cancer, light skin, or ongoing immunosuppressive therapy
• Primary hyperaldosteronism
• Renal artery stenosis (particularly bilateral renal artery stenosis, due to the risk of acute renal failure)
• Volume or salt depletion

Drug Interactions:

Before taking Olmetec Plus, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00059258.PDF.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Olmetec Plus. Olmetec Plus may interact with other medicines, including but not limited to:
• ACE inhibitors (e.g., ramipril, enalapril, lisinopril) and other ARBs: Concurrent use of Olmetec Plus with ACE inhibitors or other ARBs increases the risk of hypotension, syncope, stroke, hyperkalemia, and renal failure without providing additional cardiovascular benefit.
• Alcohol: May increase the risk of dizziness and fainting.
• Aliskiren (Rasilez): Contraindicated in patients with diabetes or moderate-to-severe renal impairment.
• Antidiabetic agents (insulin, metformin, sulfonylureas, etc.): Hydrochlorothiazide may raise blood glucose and require adjustment of antidiabetic medication dosages.
• Antihypertensive drugs and vasodilators: Additive blood-pressure-lowering effects may require dose adjustment.
• Calcium channel blockers: may cause additive blood-pressure-lowering effects that requires monitoring during co-administration
• Cholestyramine and colestipol (bile acid sequestrant resins) may impair the absorption of hydrochlorothiazide. Use Olmetec Plus at least 4 hours before or 4 to 6 hours after the resin dose.
• Ciclosporin (cyclosporine): Concurrent use with hydrochlorothiazide may increase the risk of hyperuricemia and gout-like complications.
• Corticosteroids and ACTH: May intensify electrolyte depletion (especially potassium) caused by hydrochlorothiazide.
• Digoxin: Hypokalaemia caused by hydrochlorothiazide sensitizes the heart to digoxin toxicity (ventricular arrhythmias).
• NSAIDs (non-steroidal anti-inflammatory drugs, e.g., ibuprofen, naproxen, indomethacin): May decrease the antihypertensive effect of Olmetec Plus and increase the risk of acute kidney injury.
• Potassium-lowering drugs (amphotericin B, loop diuretics, corticosteroids)
• Potassium-raising drugs (potassium-sparing diuretics such as spironolactone, eplerenone, amiloride, triamterene; potassium supplements; salt substitutes containing potassium)
• Sympathomimetic drugs (e.g., adrenaline/epinephrine, noradrenaline): May reduce the antihypertensive effect of hydrochlorothiazide.
• Warfarin and other oral anticoagulants: Hydrochlorothiazide may decrease warfarin's anticoagulant effect, requiring close INR monitoring.

Pregnancy and Breastfeeding:

Olmetec Plus is contraindicated during pregnancy. Use of angiotensin II receptor blockers (ARBs) during the second and third trimesters of pregnancy has been shown to cause fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, renal failure, and death. Discontinue Olmetec Plus immediately if pregnancy is confirmed. Do not use Olmetec Plus when breastfeeding. It is not known whether olmesartan passes into human breast milk, but hydrochlorothiazide does, and it may suppress lactation.

Use in Children:

This medicine is not approved for use in children under 18 years of age. The safety and effectiveness of Olmetec Plus have not been established in children.

Frequently Asked Questions about Olmetec Plus at Canada Pharmacy Online

Why is Olmetec Plus more affordable in Canada than in the United States?

Prescription drug prices, including Olmetec Plus, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Olmetec Plus I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Olmetec Plus per prescription from your doctor.

Can I buy Olmetec Plus from you over the counter?

No, Olmetec Plus requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Olmetec Plus?

Yes, generic olmesartan medoxomil/hydrochlorothiazide tablets are available at this pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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