One-Alpha (Alfacalcidol)

Name: One-Alpha
Brand: CheplaPharm
SKU: 7327
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: One-Alpha (ON BACKORDER)

Manufacturer: CheplaPharm

Country: Canada

Dosage: 0.25 mcg

Qty-Price (USD):

Type:

Product: One-Alpha (ON BACKORDER)

Manufacturer: CheplaPharm

Country: Canada

Dosage: 1 mcg

Qty-Price (USD):

Generic Equivalent of One-Alpha

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Alfacalcidol

Manufacturer: Generic

Country: Canada

Dosage: 0.25 mcg

Qty-Price (USD):

Type:

Product: Alfacalcidol

Manufacturer: Generic

Country: Canada

Dosage: 1 mcg

Qty-Price (USD):

One-Alpha Information

One-Alpha at CanadaPharmacyOnline.com

Brand One-Alpha (alfacalcidol) is manufactured by CheplaPharm and is available in many countries worldwide, including Canada. Generic alfacalcidol is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Alfacalcidol:

Generic alfacalcidol contains the same active ingredient as brand-name and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as One-Alpha. Studies have shown that generic alfacalcidol is bioequivalent to brand-name One-Alpha, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please refer to Access to Generic Drugs in Canada | Canada.ca

Dosage:

Brand One-Alpha is commonly available in 0.25 mcg and 1 mcg capsules. Generic alfacalcidol is available in 0.25 mcg and 1 mcg capsules.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

One-Alpha (alfacalcidol) is a prescription medication primarily used to help the body maintain healthy levels of calcium and phosphate. It is often prescribed when the body cannot properly activate natural vitamin D, which is essential for strong bones and muscles. One-Alpha is commonly used in people with chronic kidney disease, where the kidneys lose their ability to convert vitamin D into its active form. It is also used to treat low calcium levels (hypocalcemia) and disorders such as hypoparathyroidism, where the parathyroid glands do not produce enough hormone to regulate calcium. Additionally, One-Alpha helps prevent and treat bone-softening conditions like rickets in children and osteomalacia in adults. In some cases, it may also be prescribed to support bone strength in osteoporosis or to manage secondary hyperparathyroidism.

Mechanism of Action:
One-Alpha (alfacalcidol) is a vitamin D analogue. It is a synthetic prodrug of the active vitamin D hormone, calcitriol, that helps regulate calcium and phosphate balance in the body. Once taken, One-Alpha (alfacalcidol) is converted in the liver to its active form, calcitriol, which is the hormone responsible for the biological effects of vitamin D. Calcitriol binds to vitamin D receptors found in the intestines, bones, and kidneys. This interaction increases the absorption of calcium and phosphate from the intestines, helping to maintain normal levels of these minerals in the blood. It also enhances calcium reabsorption in the kidneys, preventing excessive loss through urine.

Take One-Alpha exactly as your doctor prescribes, following the instructions in the product monograph accompanying the medication. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking One-Alpha, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below outlines potential side effects associated with One-Alpha (alfacalcidol). It is not an exhaustive list, and individual reactions can vary. This information is for educational purposes and should not replace professional medical advice. Before starting One-Alpha, it is crucial to discuss possible side effects and risks with your doctor or pharmacist.

Common side effects - The following are some common side effects of One-Alpha; others may occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Abdominal pain;
• Appetite loss;
• Constipation;
• Dry mouth;
• Headache;
• Muscle pain;
• Nausea

Serious or rare side effects- Seek immediate medical attention or call emergency services if you experience any of the following: • Hypercalcemia – signs include increased thirst and frequent urination, muscle weakness, nausea, vomiting, headache, and confusion. • Irregular heartbeat.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting One-Alpha, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

One-Alpha should not be used if:
• You have a known allergy to alfacalcidol or any of the ingredients in the medication.
• You have hypercalcemia.
• You have hypervitaminosis D (vitamin D toxicity).
• You have uncontrolled hyperphosphatemia (high phosphate levels).

Tell your doctor about all of your medical conditions, past and present, before starting One-Alpha. This is crucial because certain conditions can affect whether One-Alpha is right for you. These conditions may include, but are not limited to:
• A history of kidney stones;
• A history of sarcoidosis;
• Heart disease;
• Liver disease;
• Parathyroid disorders

Drug Interactions:

Before taking One-Alpha, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Product Monograph | Sandoz.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with One-Alpha. One-Alpha may interact with other medicines, but is not limited to:
• Anticonvulsants like phenytoin, phenobarbital, or carbamazepine - These medications increase the breakdown of vitamin D analogues, which may reduce the effectiveness of One-Alpha and require dosage adjustments.
• Corticosteroids like prednisone - Steroids can counteract the effects of vitamin D by reducing calcium absorption, potentially making One-Alpha less effective.
• Digitalis, such as digoxin, can have high calcium levels caused by One-Alpha enhances its toxic effects, potentially leading to irregular heartbeats or cardiac arrhythmias.
• Other vitamin D products or calcium supplements – additional vitamin D, calcium, or phosphate supplements can increase the risk of hypercalcemia or hyperphosphatemia.
• Thiazide diuretics like hydrochlorothiazide can reduce calcium excretion through urine, leading to dangerously high calcium levels.

Pregnancy and Breastfeeding:
The safety and effectiveness of One-Alpha in pregnancy have not been established. In animal studies, high doses of vitamin D-related drugs have been linked to problems with bone development and growth in unborn babies. Doctors usually prescribe One-Alpha during pregnancy only if the benefits clearly outweigh the risks. If you do need to take it, your calcium levels will be closely monitored to prevent complications such as high calcium levels, which can affect both you and your baby. During breastfeeding, One-Alpha can pass into breast milk and may cause high calcium levels in the infant. If you're nursing, your doctor may recommend regular checks of both your calcium levels and your baby's. In some cases, they might suggest switching to formula feeding or using an alternative treatment.

Frequently Asked Questions about One-Alpha at Canada Pharmacy Online

Why is One-Alpha more affordable in Canada than in the United States?

Prescription drug prices, including One-Alpha, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is committed to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of capsules I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of One-Alpha at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, One-Alpha requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It typically takes 7-18 business days to receive your order from our pharmacy.

Is there a generic for One-Alpha?

The generic alfacalcidol is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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