Paxil (Paroxetine)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Paxil

Manufacturer: GSK

Country: United Kingdom

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Paxil

Manufacturer: GSK

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Paxil (ON BACKORDER)

Manufacturer: GSK

Country: United Kingdom

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Paxil

Manufacturer: GSK

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Paxil

Manufacturer: GSK

Country: United Kingdom

Dosage: 30 mg

Qty-Price (USD):

Generic Equivalent of Paxil

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Paroxetine

Manufacturer: Generic

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Paroxetine

Manufacturer: Generic

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Paroxetine

Manufacturer: Generic

Country: India

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Paroxetine

Manufacturer: Generic

Country: Canada

Dosage: 30 mg

Qty-Price (USD):

Type:

Product: Paroxetine

Manufacturer: Generic

Country: India

Dosage: 40 mg

Qty-Price (USD):

Paxil Information

medically reviewed by Dr. HaVy Ngo, Pharmacist on July 31, 2025.

Paxil and Paroxetine at CanadaPharmacyOnline.com

Paroxetine is marketed under the brand name Paxil in many regions. In Canada, GSK manufactures Paxil. GSK also produces paroxetine in Turkey, where it's sold as Seroxat.

Generic paroxetine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Paroxetine:

Generic paroxetine contains the same active ingredient as the brand-name Paxil and is required to meet the same safety, effectiveness, and quality standards as the brand-name product. This means it is designed to work in the same way as paroxetine, also known as Paxil. Studies have demonstrated bioequivalence between generic and brand-name paroxetine, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic paroxetine, talk to your doctor or pharmacist. For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage

Paxil and generic paroxetine are available in various oral formulations and strengths. At this pharmacy, common forms typically include:
• Oral Tablets (Immediate-Release):
o 10 mg
o 20 mg
o 30 mg
o 40 mg
• Oral Tablets (Controlled-Release, please visit Paxil CR at https://www.canadapharmacyonline.com/DrugInfo.aspx?name=Paxil+CR2522):

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage

Paxil (paroxetine) is a prescription medication used to treat a variety of mental health conditions by helping to restore the balance of a natural substance (serotonin) in the brain. Common uses include:
• Generalized Anxiety Disorder (GAD): Treatment of excessive worry and anxiety.
• Major Depressive Disorder (MDD): Treatment of depression in adults.
• Obsessive-Compulsive Disorder (OCD): Management of obsessive thoughts and compulsive behaviors.
• Panic Disorder: Prevention of panic attacks, with or without agoraphobia (fear of open or public places).
• Post-Traumatic Stress Disorder (PTSD): Treatment of anxiety symptoms following a traumatic event.
• Social Anxiety Disorder (Social Phobia): Management of extreme fear in social situations.

Mechanism of Action
Paxil (paroxetine) primarily exerts its therapeutic effects by selectively inhibiting the reuptake of serotonin (5-HT) in central nervous system (CNS) neurons. By blocking the serotonin transporter protein, paroxetine increases the concentration of serotonin in the synaptic cleft, thereby enhancing serotonergic neurotransmission. This modulation of serotonin levels is believed to contribute to its antidepressant, anxiolytic, and anti-obsessive effects. Paroxetine has a relatively high affinity for the serotonin transporter and has minimal affinity for other neurotransmitter receptors.

Take Paxil exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Paxil, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Paxil, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects - The following are some common side effects of Paxil; other side effects may also occur. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abnormal ejaculation/erection difficulties (men)
• Anxiety
• Blurry vision
• Constipation
• Decreased libido (sex drive)
• Diarrhea
• Dizziness
• Drowsiness/Sedation
• Dry mouth
• Fatigue/Weakness
• Headache
• Insomnia (difficulty sleeping)
• Nausea
• Nervousness
• Sexual dysfunction (e.g., anorgasmia)
• Sweating
• Tremor
• Yawning

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions: Severe rash, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, wheezing, and itching.
• Bleeding problems: Easy bruising, unusual bleeding (e.g., nosebleeds, bleeding gums, stomach bleeding), particularly if taking other medications that affect bleeding (e.g., NSAIDs, warfarin). Increased risk of postpartum hemorrhage if used in late pregnancy.
• Bone Fractures: Increased risk of bone fractures with long-term paroxetine use, especially in the elderly.
• Central Nervous System (CNS) effects:
o Agitation, hallucinations, delirium
o Akathisia (restlessness, inability to sit still)
o Confusion
o Difficulty concentrating
o Mania or hypomania (excessively elevated mood, increased energy, racing thoughts, decreased need for sleep)
o Seizures/Convulsions
• Hyponatremia (low sodium levels in blood): Symptoms include headache, confusion, weakness, unsteadiness, or seizures. This is more common in elderly patients and those taking diuretics.
• Neuroleptic Malignant Syndrome (NMS)-like reactions: Rare but serious condition characterized by fever, muscle rigidity, altered mental status, and autonomic instability (e.g., irregular pulse or blood pressure, excessive sweating, tachycardia).
• Ocular effects:
o Angle-closure glaucoma: Eye pain, changes in vision, swelling, or redness in or around the eye.
o Mydriasis (dilation of pupil): Can precipitate angle-closure glaucoma in susceptible individuals.
• Serotonin Syndrome: A potentially life-threatening condition caused by an excess of serotonin. Symptoms include agitation, hallucinations, rapid heartbeat, fever, sweating, shivering, severe muscle stiffness or spasms, loss of coordination, nausea, vomiting, or diarrhea.
• Sexual Dysfunction, Persistent: In some cases, sexual dysfunction (e.g., decreased libido, anorgasmia, erectile dysfunction) may persist after discontinuation of SSRIs
• Suicidal Thoughts or Behavior: New or worsening depression, suicidal thoughts or behavior (especially in children, adolescents, and young adults under 25, particularly during initial treatment or dose changes). This is a Black Box Warning for Paxil.
• Withdrawal symptoms (Discontinuation Syndrome): Symptoms that occur upon abrupt discontinuation, especially after long-term use, can include dizziness, sensory disturbances (e.g., "electric shock" sensations), sleep disturbances, agitation, anxiety, nausea, sweating, and tremors. Tapering the dose slowly is recommended.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Paxil, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Paxil should not be used if:
• You are allergic to paroxetine or any other ingredient in Paxil.
• You are taking a monoamine oxidase inhibitor (MAOI) or have taken one within the last 14 days (e.g., isocarboxazid, phenelzine, selegiline, tranylcypromine, linezolid, methylene blue injection). A dangerous drug interaction (Serotonin Syndrome) can occur.
• You are taking pimozide (an antipsychotic). Concomitant use can lead to QT prolongation and severe cardiac events.
• You are taking thioridazine (an antipsychotic). Concomitant use can lead to serious ventricular arrhythmias and sudden death due to elevated thioridazine plasma levels.

Tell your doctor about all of your medical conditions, past and present, before starting Paxil. This is crucial because certain conditions affect whether Paxil is right for you. These conditions may include, but are not limited to:
• Bipolar disorder (or a family history of)
• Bleeding disorders
• Cardiac disease (history of, especially QT prolongation or recent myocardial infarction)
• Conditions that predispose to hypovolemia or dehydration.
• Diabetes
• Epilepsy or history of seizures
• Glaucoma (especially narrow-angle glaucoma)
• History of neuroleptic malignant syndrome (NMS)
• History of suicidal attempts or ideation
• Kidney impairment
• Liver impairment
• Mania or hypomania (history of)
• Sodium imbalance (low sodium levels)
• Stroke or transient ischemic attack (TIA)

Drug Interactions

Before taking Paxil, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the official product monograph for Paxil | GSK.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also essential to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Paxil. Paxil may interact with other medicines, but is not limited to:
• Amphetamines
• Anticoagulants (blood thinners, e.g., warfarin) and Antiplatelet Agents (e.g., aspirin, NSAIDs): Increased risk of bleeding. Monitor closely.
• Antidepressants (other SSRIs, SNRIs, TCAs) and Serotonergic Drugs: Increased risk of Serotonin Syndrome. Examples include:
o Linezolid (antibiotic)
o Lithium
o SNRIs (e.g., venlafaxine, duloxetine)
o SSRIs (e.g., fluoxetine, sertraline, citalopram)
o St. John's Wort (herbal supplement)
o Tramadol, Fentanyl, Meperidine (opioid pain relievers)
o Tricyclic Antidepressants (TCAs) (e.g., amitriptyline, imipramine)
o Triptans (for migraines, e.g., sumatriptan, zolmitriptan)
o Tryptophan
• Antipsychotics (e.g., thioridazine, pimozide): Concomitant use with thioridazine and pimozide is contraindicated. May increase plasma levels of other antipsychotics (e.g., risperidone, perphenazine) due to CYP2D6 inhibition.
• Cimetidine (H2 blocker): Can significantly increase paroxetine levels.
• CYP2D6 Substrates (e.g., metoprolol, flecainide, propafenone, atomoxetine, some TCAs): Paroxetine is a potent inhibitor of CYP2D6 and can significantly increase the plasma levels of drugs metabolized by this enzyme, potentially leading to increased side effects or toxicity of the co-administered drug.
• Fosamprenavir/Ritonavir: These can significantly increase paroxetine levels.
• Monoamine Oxidase Inhibitors (MAOIs): Contraindicated. Risk of Serotonin Syndrome.
• Phenobarbital, Phenytoin: Can reduce paroxetine levels.
• Procyclidine: Paroxetine may increase procyclidine levels.
• Tamoxifen: Concomitant use may reduce the effectiveness of tamoxifen (as paroxetine is a potent inhibitor of CYP2D6, which is crucial for tamoxifen activation). Avoid if possible.
• Theophylline: Paroxetine may increase theophylline levels. Avoid alcohol use while taking Paxil. Concomitant use with alcohol may worsen central nervous system side effects such as drowsiness and dizziness.

Pregnancy and Breastfeeding

Pregnancy and Breastfeeding Use of paroxetine during pregnancy, particularly in the first trimester, has been associated with an increased risk of congenital malformations, especially cardiovascular defects (e.g., ventricular septal defects). Use in late pregnancy (third trimester) has been associated with an increased risk of persistent pulmonary hypertension of the newborn (PPHN) and neonatal withdrawal symptoms (also known as Neonatal Abstinence Syndrome or poor neonatal adaptation syndrome) (e.g., respiratory distress, feeding difficulties, jitteriness, hypotonia, persistent crying, seizures). Paxil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. If you are pregnant or planning to become pregnant, discuss this with your doctor.

Paroxetine is excreted into human milk. While the amount transferred is generally low, potential risks to the infant cannot be excluded, especially for very young or premature infants. A decision should be made whether to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Consult your doctor for personalized advice.

Use in the Elderly

Elderly patients may be more sensitive to the effects of Paxil, particularly side effects such as hyponatremia and CNS effects (e.g., dizziness, somnolence, gait disturbance), which can increase the risk of falls. Lower starting doses and careful titration are often recommended. The risk of bleeding (especially upper GI bleeding) and bone fractures may also be increased.

Use in Children

Paxil is not approved for use in pediatric patients for major depressive disorder or generalized anxiety disorder in Canada. Its use in children and adolescents for MDD is generally discouraged due to the increased risk of suicidality. It is approved for Obsessive-Compulsive Disorder (OCD) and Social Anxiety Disorder in certain pediatric age groups, but only after careful consideration by a specialist. All patients, especially children, adolescents, and young adults (up to age 24), should be closely monitored for worsening depression, suicidal thoughts, or unusual changes in behavior, particularly when starting treatment or changing dosage.

Frequently Asked Questions about Paxil at Canada Pharmacy Online:

Why is Paxil more affordable in Canada than in the United States?

Prescription drug prices, including Paxil, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to providing you with the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Paxil at a time, as per your doctor's prescription.

Can I buy over the counter from you?

No, Paxil requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the best time to take Paxil?

Paxil is usually taken once daily, typically in the morning with or without food. Taking it at the same time each day helps maintain a consistent level of the medication in your body. If you experience drowsiness, your doctor might suggest taking it in the evening. Follow your doctor's specific instructions.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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