Polytrim Drops (Polymyxin B Sulfate/Trimethoprim)

Name: Polytrim Drops
Brand: Generic
SKU: 7334
Availability: InStock

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There is no brand product of Polytrim Drops.

Generic Equivalent of Polytrim Drops

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Type:

Product: Polymyxin B Sulfate/Trimethoprim

Manufacturer: Generic

Country: Canada

Dosage: 10000 IU/ml/0.1 %/10 ml

Qty-Price (USD):

Polytrim Drops Information

Polymyxin B sulfate/trimethoprim at CanadaPharmacyOnline.com

The manufacturer of Polytrim (polymyxin B sulfate and trimethoprim) is Allergan, a global pharmaceutical leader in eye care. Polytrim is a widely used prescription antibiotic eye drop designed to treat bacterial infections of the eye. In Canada, it is marketed under the same brand name and remains a standard treatment for surface-level ocular infections. The brand Polytrim Drops is currently unavailable (at this pharmacy).

Generic polymyxin B sulfate/trimethoprim ophthalmic solution is produced by several manufacturers that meet the strict regulatory standards for safety and quality set by Health Canada and the FDA. Common generic producers include Sandoz, Apotex, and Bausch and Lomb. Generic versions are sourced from manufacturers that meet applicable regulatory standards. However, the specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Polymyxin B sulfate/trimethoprim

Generic polymyxin B sulfate/trimethoprim contains the same active ingredient as brand-name Polytrim Drops. It must meet the same effectiveness and quality standards. This means it is designed to work like Polytrim Drops. Studies have shown that generic polymyxin B sulfate/trimethoprim is bioequivalent to brand-name Polytrim Drops, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Polymyxin B sulfate/trimethoprim is available in the following strengths and forms:
• Eye Drops: 10,000 units/mL polymyxin B sulfate and 1 mg/mL trimethoprim. It is usually supplied in 5 mL or 10 mL plastic dropper bottles.

In adults and children (2 months and older), the standard dosage is 1 drop in the affected eye(s) every 3 hours (up to 6 times daily) for 7 to 10 days, depending on the severity of the infection.

Usage:

Polytrim Drops is a combination antibiotic eye drop used to treat surface-level bacterial infections of the eye, most commonly bacterial conjunctivitis (pink eye). It combines two different antibiotics to provide broad-spectrum coverage against a wide variety of Gram-positive and Gram-negative bacteria. By clearing the infection, Polytrim helps resolve symptoms like eye redness, discharge (pus), swelling, and irritation. Because it is an antibiotic, it is only effective against bacterial infections. It will not work for viral pink eye, allergic reactions, or fungal infections. It is essential to complete the full course of treatment as prescribed by your doctor, even if your symptoms improve after a few days, to ensure the infection is completely eradicated.

Mechanism of Action
Polytrim works through the synergistic action of its two components, which attack bacteria differently. Polymyxin B acts as a bactericidal agent by targeting the bacterial cell membrane. It acts like a detergent, binding to the membrane and disrupting its integrity, causing the cell's contents to leak and leading to rapid cell death. Trimethoprim is a bacteriostatic agent that inhibits bacterial protein synthesis. It blocks a specific enzyme (dihydrofolate reductase) that is necessary for the production of folic acid, which the bacteria need to synthesize DNA. Together, these two mechanisms make it very difficult for bacteria to survive or reproduce, effectively clearing the infection from the surface of the eye.

Use Polytrim exactly as your doctor prescribes, following the instructions in the product monograph. To avoid contamination, do not touch the dropper tip to your eye, eyelid, or any other surface. Complete the full course of therapy to prevent the infection from returning.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Polytrim Drops, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Polytrim Drops (polymyxin B sulfate/trimethoprim). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Polytrim Drops; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Blurred vision (immediately after application)
• Eye redness or itching
• Eyelid swelling (blepharitis)
• Temporary stinging or burning when the drops are applied

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat, hives, and difficulty breathing.
• Secondary Infection: If the condition does not improve or gets worse after several days of treatment, a secondary fungal or viral infection may be present.
• Severe Local Irritation: Intense pain, burning, or worsening redness that does not go away.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Polytrim Drops, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Polytrim Drops/polymyxin B sulfate/trimethoprim if:
• Allergies: You have a known hypersensitivity to polymyxin B, trimethoprim, or any other ingredients in the solution.

Tell your doctor about all of your medical conditions, past and present, before starting Polytrim Drops. This is crucial as certain conditions affect the drug's safety.
• Contact Lens Use: You should not wear contact lenses while you have symptoms of an eye infection. Polytrim contains benzalkonium chloride, a preservative that soft contact lenses can absorb.
• Pregnancy or Nursing: Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Drug Interactions:

Before taking Polytrim Drops, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the manufacturer’s website at https://www.rxabbvie.com/pdf/polytrim_pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Polytrim Drops. Polytrim Drops may interact with other medicines, including but not limited to:
• Other Eye Medications: If you are using other eye drops or ointments, wait at least 5 to 10 minutes between applications to prevent the first medication from being washed out.

Pregnancy and Breastfeeding:

Polytrim should be used during pregnancy only if the potential benefit justifies the risk to the fetus. It is unknown if the ingredients pass into breast milk in significant amounts. Consult your doctor before breastfeeding while using these drops.

Use in Children:

Polytrim is approved for use in children 2 months of age and older. The safety and effectiveness in infants under 2 months have not been established.

Frequently Asked Questions about Polytrim Drops at Canada Pharmacy Online

Why is Polytrim Drops more affordable in Canada than in the United States?

Prescription drug prices, including Polytrim Drops, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Polytrim Drops I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Polytrim Drops per prescription from your doctor.

Can I buy Polytrim Drops from you over the counter?

No, Polytrim Drops requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Polytrim Drops?

Yes, there is a generic alternative to Polytrim Drops: polymyxin B sulfate/trimethoprim.

Blog Post:

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Latest News:

NIH grant to Wayne State supports research into mitigating the lasting effects from eye infections (news published on November 3, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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