Prandin (Repaglinide)

Name: Prandin
Brand: Novo Nordisk
SKU: 1864
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Prandin

Manufacturer: Novo Nordisk

Country: Turkey

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Prandin

Manufacturer: Novo Nordisk

Country: Turkey

Dosage: 1 mg

Qty-Price (USD):

Generic Equivalent of Prandin

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Repaglinide

Manufacturer: Generic

Country: Canada

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Repaglinide

Manufacturer: Generic

Country: United Kingdom

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Repaglinide

Manufacturer: Generic

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Repaglinide

Manufacturer: Generic

Country: United Kingdom

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Repaglinide

Manufacturer: Generic

Country: Canada

Dosage: 2 mg

Qty-Price (USD):

Type:

Product: Repaglinide

Manufacturer: Generic

Country: United Kingdom

Dosage: 2 mg

Qty-Price (USD):

Prandin Information

medically reviewed by Carol Hou (BSc. Pharm) on June 13, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Prandin and Repaglinide at CanadaPharmacyOnline.com

Brand Prandin, manufactured by Novo Nordisk, is available in Turkey.

Generic Repaglinide is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Repaglinide:

Generic repaglinide contains the same active ingredient as the brand-name Prandin. It is required to meet the same safety, effectiveness, and quality standards.

This means it is designed to work in the same way as Prandin. While specific bioequivalence studies are conducted to ensure generic medications have comparable absorption rates and overall effects, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about using generic repaglinide.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Prandin (repaglinide) is typically available as oral tablets in strengths of 0.5 mg, 1 mg, and 2 mg.

Your doctor will determine the appropriate dosage based on your needs and medical conditions.

Usage:

Prandin (repaglinide) is a prescription medication used to help control blood sugar in adults with type 2 diabetes, in conjunction with exercise and diet. Your doctor will determine the appropriate dosage and duration of treatment. It is crucial to follow your doctor’s prescribed dosing regimen.

For more information, refer to the product labelling information, https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020741s040lbl.pdf.

Mechanism of Action:
Prandin (repaglinide) belongs to a class of medications called meglitinides, also known as “prandial glucose regulators” or “insulin secretagogues.” It helps manage blood sugar in type 2 diabetes by encouraging the pancreas to release more insulin. It works by specifically targeting and stimulating the cells in the pancreas responsible for insulin production, causing them to release insulin primarily when blood sugar levels are high, like after a meal. This action quickly helps lower the sugar in your blood, especially after eating, making it an effective way to control mealtime blood sugar spikes.

Use Prandin exactly as your doctor prescribes. Do not change your dosage or stop using the medication without consulting your doctor. Always follow the instructions on the repaglinide information | Mayo Clinic.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Prandin, it is essential to discuss all possible aspects with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Prandin, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects: These are examples of some common side effects of Prandin, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Back pain
• Diarrhea
• Headache
• Joint pain (arthralgia)
• Nausea
• Sinusitis
• Upper respiratory infection

Serious or rare side effects: Stop taking Prandin and seek immediate medical attention if you experience any of the following:
• Hemolytic Anemia: A rare type of anemia in which red blood cells are destroyed.
• Liver Problems: Severe hepatic dysfunction, including jaundice (yellowing of skin or eyes) and hepatitis (liver inflammation).
• Pancreatitis: Inflammation of the pancreas, which can cause severe upper stomach pain radiating to the back, nausea, and vomiting.
• Serious Skin Reactions: Including blistering, peeling, or spreading red or purple skin rash (e.g., Stevens-Johnson Syndrome).
• Severe Allergic Reactions: Symptoms such as hives, severe rash, swelling of the face, lips, tongue, or throat, and difficulty breathing.
• Severe Hypoglycemia (Very Low Blood Sugar): While low blood sugar is common, severe hypoglycemia can lead to seizures, unconsciousness, or be life-threatening.

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Prandin.

Prandin should not be used if:
• Concomitant use of Gemfibrozil: This is a critical drug interaction. Gemfibrozil significantly increases repaglinide levels, leading to a profound risk of severe, prolonged hypoglycemia (dangerously low blood sugar).
• Concomitant use of NPH insulin: Prandin is not indicated for use in combination with NPH insulin.
• Diabetic ketoacidosis (DKA), with or without coma: In DKA, the body needs insulin, and oral medications like Prandin are ineffective and inappropriate
• Known hypersensitivity (allergy) to repaglinide or any of its excipients (inactive ingredients): Any known severe allergic reaction to the drug itself or its components makes its use an absolute contraindication.
• Type 1 Diabetes Mellitus: Prandin requires functioning pancreatic beta cells to stimulate insulin release, which are absent or severely compromised in Type 1 diabetes.

Tell your doctor about all of your medical conditions, past and present, before starting Prandin. This is crucial because certain conditions can affect whether Prandin is right for you. These conditions may include, but are not limited to:
• Adrenal or Pituitary Insufficiency: Patients with these conditions are more susceptible to hypoglycemia because their bodies may have a diminished ability to counteract low blood sugar. Prandin use would require very careful monitoring.
• Intercurrent Conditions: During periods of stress such as fever, trauma, infection, or surgery, the blood sugar control of patients with diabetes may worsen. In such cases, it may be necessary to discontinue Prandin and administer insulin temporarily. This is more of a temporary contraindication for the duration of the acute stress.
• Malnutrition, Debilitating Conditions, or Advancing Age: These patient populations are also more prone to developing hypoglycemia due to various physiological factors. Dosage adjustments and careful monitoring are crucial.
• Patients with Hypoglycemia Unawareness: Individuals who don't experience the typical warning symptoms of low blood sugar (e.g., due to long-standing diabetes or certain medications) are at higher risk of severe hypoglycemia with Prandin, making its use more challenging.
• Severe Hepatic (Liver) Impairment: Repaglinide is extensively metabolized by the liver. Severe liver disease can lead to higher and more prolonged plasma concentrations of repaglinide, increasing the risk of hypoglycemia. Prandin is generally not recommended in these patients or should be used with extreme caution and reduced doses.
• Severe Renal (Kidney) Impairment: While not an absolute contraindication, severe kidney problems (creatinine clearance of 20 to 40 mL/min) significantly affect how repaglinide is cleared from the body. The recommended starting dose is lower (0.5 mg), and careful dose titration is necessary to avoid accumulation and increased risk of hypoglycemia. For end-stage renal disease patients on dialysis, there's limited data, and it's generally approached with extreme caution.

Drug Interactions:

Before taking Prandin, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Prandin: Package Insert / Prescribing Info | Drugs.com: https://www.drugs.com/pro/prandin.html.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Prandin may interact with other medicines, including but not limited to:
• Alcohol Intake: Alcohol can potentiate the hypoglycemic effect of repaglinide, increasing the risk of low blood sugar. Patients should be advised on cautious alcohol consumption.
• Concomitant use of certain medications (CYP2C8 and CYP3A4 inhibitors/inducers): While specific inhibitors like gemfibrozil are absolute contraindications, other less potent inhibitors or inducers of these liver enzymes (e.g., clarithromycin, cyclosporine, rifampin) can still alter repaglinide levels, requiring dose adjustments and careful monitoring. This is a precaution rather than a strict contraindication for many of these.
• Drugs that Increase Blood Glucose (Counteract Prandin's Effect):
o Corticosteroids (e.g., prednisone)
o Diuretics (water pills): Thiazide diuretics in particular.
o Estrogens and oral contraceptives
o Isoniazid (for tuberculosis)
o Niacin (nicotinic acid)
o Phenothiazines (antipsychotics)
o Sympathomimetics (e.g., decongestants, asthma medications)
o Thyroid hormones
• Gemfibrozil (a lipid-lowering agent): This is a major and contraindicated interaction. Gemfibrozil is a potent inhibitor of CYP2C8 and significantly increases repaglinide exposure (by about 8-fold), leading to a high risk of severe and prolonged hypoglycemia. Co-administration is absolutely contraindicated.
• Other Medications that may increase hypoglycemic effect:
o Aspirin and other salicylates
o Beta-blockers (e.g., propranolol, metoprolol): Can mask the symptoms of hypoglycemia (like tremors and rapid heartbeat), making it harder for patients to recognize and treat low blood sugar. They may also affect glucose metabolism.
o Monoamine oxidase inhibitors (MAOIs)
o Non-steroidal anti-inflammatory drugs (NSAIDs)
o Other antidiabetic agents: Combining Prandin with other diabetes medications (e.g., metformin, insulin, GLP-1 receptor agonists) can increase the risk of hypoglycemia, and dose adjustments may be necessary.
o Probenecid (for gout)
o Sulfonamides (sulfa drugs)

Pregnancy and Breastfeeding:

Caution is advised when taking Prandin as its safety in these situations hasn’t been fully established through human studies. For pregnant individuals with diabetes, insulin is generally the preferred treatment to safely manage blood sugar and prevent risks to both mother and baby. If you are pregnant or breastfeeding, or planning to be, it is crucial to have a thorough discussion with your doctor, who will help determine the safest and most effective approach for your diabetes management, considering all potential benefits and risks.

Use in Children:

Prandin is not recommended for use in children. Its safety and effectiveness have only been confirmed in adults with type 2 diabetes. Therefore, there’s no reliable information on how it might affect younger patients, and it shouldn’t be given to individuals under the age of 18.

Frequently Asked Questions about Prandin at CanadaPharmacyOnline.com:

Why is Prandin more affordable in Canada than in the United States?

Prescription drug prices, including Prandin, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I buy over the counter from you?

No, Prandin requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Prandin at once, per your doctor's prescription.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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