Proamatine (Midodrine)

Name: Proamatine
Brand: Generic
SKU: 5486
Availability: InStock

Type

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Qty-Price (USD)

There is no brand product of Proamatine.

Generic Equivalent of Proamatine

Type

Product

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Type:

Product: Midodrine

Manufacturer: Generic

Country: Canada

Dosage: 2.5 mg

Qty-Price (USD):

Type:

Product: Midodrine

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Proamatine Information

Midodrine at CanadaPharmacyOnline.com

In Canada, the brand-name version of midodrine hydrochloride is historically known as Amatine or Proamatine. The brand Proamatine is currently unavailable at this pharmacy.

Generic midodrine is also available and is produced by several reputable pharmaceutical companies that meet the rigorous standards. Generic midodrine is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Midodrine

Generic midodrine contains the same active ingredient as brand-name Proamatine. It must meet the same effectiveness and quality standards. This means it is designed to work like Proamatine. Studies have shown that generic midodrine is bioequivalent to brand-name Proamatine, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information on generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Midodrine is available in the following oral strengths at this pharmacy:
• Tablets: 2.5 mg and 5 mg.

The usual starting dose is 2.5 mg three times daily during the hours when the patient is upright (typically in the morning, midday, and early afternoon). The dose may be increased if needed. Midodrine must not be taken within 4 hours of bedtime, as it can cause dangerously high blood pressure while lying down (supine hypertension).

Usage:

Proamatine (midodrine hydrochloride) is indicated for the treatment of symptomatic orthostatic hypotension (low blood pressure on standing) that is severe enough to significantly impair daily activities, in patients who have not responded adequately to non-pharmacological measures. Orthostatic hypotension causes dizziness or fainting when standing up because blood pressure drops too much with the change in position. Midodrine is used only when low blood pressure is significantly affecting the patient's daily life.

Mechanism of Action
Midodrine, the active ingredient in Proamatine, is a prodrug that is converted in the body to its active form, desglymidodrine, an alpha-1 adrenergic receptor agonist. It activates alpha-1 receptors. This causes blood vessels, particularly the peripheral arteries and veins, to constrict, raising blood pressure and reducing blood pooling in the lower limbs when standing. This helps to maintain blood pressure when the patient moves from lying down to standing.

Take Proamatine exactly as your doctor prescribes, as directed in the Product Monograph. Do not take within 4 hours of bedtime. Take only during the waking, upright hours of the day.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Proamatine, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Proamatine (midodrine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Proamatine; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning.
• Chills or goosebumps (piloerection)
• Headache or feeling of pressure in the head
• Increased urination
• Nausea
• Tingling or itching of the scalp

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Severe Allergic Reaction: Hives, swelling of the face, lips, tongue, or throat, or difficulty breathing.
• Supine Hypertension (High Blood Pressure While Lying Down): Severe headache, pounding heartbeat, blurred vision, or slow pulse when lying down. Midodrine should never be taken close to bedtime. Blood pressure must be monitored regularly.
• Urinary Retention: Difficulty urinating or inability to urinate. Midodrine can cause retention of urine, particularly in men with prostate enlargement.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Proamatine, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Proamatine/midodrine if:
• Allergies: You have a known hypersensitivity to midodrine or any of its ingredients.
• Heart Disease: Severe organic heart disease, acute kidney disease, or urinary retention.
• Supine Hypertension: Your blood pressure is already high when lying down.
• Thyrotoxicosis (Overactive Thyroid) or Pheochromocytoma.

Tell your doctor about all of your medical conditions, past and present, before starting Proamatine. This is crucial as certain conditions affect the drug's safety.
• Diabetes — midodrine may affect blood glucose and the symptoms of hypoglycemia
• Enlarged prostate — increased risk of urinary retention
• Glaucoma (closed-angle)
• Kidney or liver disease
• Visual problems

Drug Interactions:

Before taking Proamatine, discuss all potential risks and interactions with your doctor or pharmacist. For complete information, please refer to the product monograph at https://pdf.hres.ca/dpd_pm/00010568.PDF

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Proamatine. Proamatine may interact with other medicines, including but not limited to:
• Alpha-blockers (e.g., prazosin, tamsulosin, terazosin): Direct antagonists of midodrine's action; counteract its blood-pressure-raising effect.
• Cardiac glycosides (e.g., digoxin): May cause or worsen bradycardia (slow heartbeat) when combined with midodrine.
• Corticosteroids (e.g., fludrocortisone): Often co-prescribed for orthostatic hypotension; additive increase in blood pressure — monitor closely.
• Other vasopressors: Additive effects; may cause dangerously high blood pressure.

Pregnancy and Breastfeeding:

Midodrine is not recommended during pregnancy. It should not be used unless the potential benefit to the mother clearly outweighs the potential risk to the fetus. Consult your doctor immediately if you become pregnant while taking Proamatine.

It is unknown whether midodrine passes into breast milk. Breastfeeding is not recommended while taking Proamatine. Discuss the risks and benefits with your doctor.

Use in Children:

The safety and efficacy of Proamatine in children have not been established. It is not recommended for use in patients under 18 years of age.

Frequently Asked Questions about Proamatine at Canada Pharmacy Online

Why is Proamatine more affordable in Canada than in the United States?

Prescription drug prices, including Proamatine, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1.866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Proamatine I can order at once?

CanadaPharmacyOnline.com can dispense up to a 3-month supply of Proamatine per doctor’s prescription.

Can I buy Proamatine from you over the counter?

No, Proamatine requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Proamatine?

Yes, the generic alternative is available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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