Prograf (Tacrolimus Immediate Release)

Name: Prograf
Brand: Astellas Pharma
SKU: 1906
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Prograf Capsule

Manufacturer: Astellas Pharma

Country: Canada

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Prograf Capsule

Manufacturer: Astellas Pharma

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Prograf Capsule

Manufacturer: Astellas Pharma

Country: Turkey

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Prograf Capsule

Manufacturer: Astellas Pharma

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Generic Equivalent of Prograf

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Tacrolimus Immediate Release Capsule

Manufacturer: Generic

Country: Canada

Dosage: 0.5 mg

Qty-Price (USD):

Type:

Product: Tacrolimus Immediate Release (Tacrograf-Biocon)

Manufacturer: Generic

Country: India

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Tacrolimus Immediate Release Capsule

Manufacturer: Generic

Country: Canada

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Tacrolimus Immediate Release Capsule

Manufacturer: Generic

Country: India

Dosage: 1 mg

Qty-Price (USD):

Type:

Product: Tacrolimus Immediate Release Capslue (Pangraf-Panacea Biotec)

Manufacturer: Generic

Country: India

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Tacrolimus Immediate Release Capsule

Manufacturer: Generic

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Prograf Information

medically reviewed by Carol Hou (BSc. Pharm) on July 3, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Prograf and Tacrolimus Immediate Release at CanadaPharmacyOnline.com

Brand Prograf, manufactured by Astellas Pharma, is available in many countries worldwide, including Canada and Turkey.

Generic tacrolimus immediate release is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Tacrolimus immediate release:

Generic tacrolimus immediate release contains the same active ingredient as the brand-name Prograf and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Prograf. Studies have demonstrated bioequivalence between generic and brand-name tacrolimus immediate-release formulations, indicating comparable absorption rates and overall effects. However, individual responses to any medication can vary. If you have any questions about using generic tacrolimus immediate-release, talk to your doctor or pharmacist.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/buying-using-medicine-safely/generic-drugs

Dosage:

Prograf, a brand-name medication, is available in 0.5 mg, 1 mg, and 5 mg capsules. The generic version, tacrolimus immediate release, is also available in 0.5 mg, 1 mg, and 5 mg capsules.

Your doctor will determine the appropriate dosage based on the individual needs and medical conditions.

Usage:

Prograf (tacrolimus immediate release) is a prescription medication used for the prophylaxis of organ rejection in patients who have received a kidney, liver, lung, or heart transplant. Organ rejection occurs when a recipient's immune system mistakenly attacks a transplanted organ, perceiving it as foreign. The body's immune system tries to defend itself against the new organ, which it sees as a threat, even if the donor is a good match. This can lead to the organ failing. Prograf is often used in combination with other immunosuppressants.

Mechanism of Action:
Prograf (tacrolimus immediate release) is a calcineurin inhibitor. It suppresses the body's immune system, specifically by inhibiting the activation of T-lymphocytes. This prevents the immune system from attacking and rejecting the transplanted organ.

Take Prograf exactly as your doctor prescribes, following the instructions in the Highlights of Prescribing Information | Astellas. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Prograf, it is essential to discuss all potential side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Prograf, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – The following are examples of some common side effects of Prograf; other side effects may also occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Anemia
• Diarrhea
• Headache
• Insomnia
• Nausea
• Tremor
• Vomiting

Serious or rare side effects – Stop taking Prograf and seek immediate medical attention right away if you experience any of the following:
• Allergic reactions, including angioedema, hives, and trouble breathing
• Behavior changes
• Fast or pounding heartbeats
• New cancers or lymphoma
• Signs of high blood sugar, including increased thirst, increased urination, hunger, appetite loss, and drowsiness
• Signs of high potassium level, including nausea, weakness, chest pain, irregular heartbeat
• Signs of low blood cell counts, including fever, flu symptoms, pale skin, tiredness

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Prograf.

Prograf should not be used if:
• Are allergic to tacrolimus immediate release or any of the inactive ingredients in Prograf
• You are scheduled to receive a live vaccine

Tell your doctor about all of your medical conditions, past and present, before starting Prograf. This is crucial because certain conditions affect whether Prograf is right for you. These conditions may include, but are not limited to:
• A history of seizures or other neurological disorders
• Diabetes
• Hyperkalemia
• Liver, kidney, or heart problems unrelated to your transplant
• Personal or family history of long QT syndrome

Drug Monitoring:
Your doctor will frequently conduct blood tests to ensure the appropriate dosing and that Prograf is not causing any harmful effects.

Infections:
Prograf may increase your risk of developing a severe infection, lymphoma, or other cancers. Your risk may be higher if treated with Prograf for extended periods, as it can weaken the immune system. Discuss the risks and benefits of using this medicine with your doctor. Avoid being near people who are sick or have infections.

Nephrotoxicity:
Prograf can cause kidney damage, especially if you use other medicines that are harmful to your kidneys. Your doctor will closely monitor your kidney function.

Neurotoxicity:
Prograf can affect the nervous system. Report any unusual neurological symptoms to your doctor. Call your doctor right away if you have symptoms, such as a change in your mental state, problems with speech or walking, severe headaches, seizures, or decreased vision. These symptoms may start gradually and worsen rapidly.

Drug Interactions:

Before taking Prograf, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about potential drug interactions, consult the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00050217.PDF and discuss any concerns with your healthcare provider.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Prograf can interact with other medicines but is not limited to itraconazole, erythromycin, verapamil, diltiazem, phenytoin, rifampin, diuretics, and live vaccines.

Grapefruit:
Do not consume grapefruit products while using Prograf. Grapefruit can increase tacrolimus levels in the blood and lead to toxicity.

Pregnancy and Breastfeeding:

If you are pregnant or become pregnant, tell your doctor before using Prograf. Tacrolimus's immediate release will harm an unborn baby. This drug should only be used in pregnancy if the benefits outweigh the risks. Use effective birth control before and during treatment with Prograf to prevent pregnancy. If you are a man, use birth control before and during treatment with Prograf if your sex partner can get pregnant. If you are breastfeeding or plan to breastfeed, inform your doctor. Tacrolimus immediate release is excreted in human breast milk and may harm a nursing infant. Do not breastfeed while using this medicine.

Frequently Asked Questions about Prograf at Canada Pharmacy Online

Why is Prograf more affordable in Canada than in the United States?

Prescription drug prices, including Prograf, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs than the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I cut or split a Prograf capsule?

It is generally not recommended to cut, split, or chew Prograf capsules. Crushing or breaking the capsules can lead to an incorrect dose of the drug and potentially cause adverse effects. Always swallow the capsule whole.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, please visit our How to Order page.

Is there a limit on how many Prograf capsules I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Prograf at one time, as per your doctor's prescription.

Can I buy Prograf over the counter from you?

No, Prograf requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What is the difference between Prograf 0.5 mg, 1 mg, and 5 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

Can I take Prograf without food?

Take Prograf on an empty stomach at least 1 hour before or 2 hours after a meal, as directed by your doctor.

Blog Posts:

5 Surprising Factors That Could Be Affecting Your Skin Health

Latest News:

A population-based analysis of immunosuppression therapy after organ transplantation (research published on May 15, 2025)

Similar Drugs in the category of Immunosuppressive Agents :

Rapamune Medrol Imuran Florinef Myfortic

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers