Qternmet XR (Dapagliflozin/Saxagliptin/Metformin Hydrochloride)

Name: Qternmet XR
Brand: AstraZeneca
SKU: 7578
Availability: InStock

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Type:

Product: Qternmet XR AVAILABLE SOON

Manufacturer: AstraZeneca

Country: Canada

Dosage:

Qty-Price (USD):

Generic Equivalent of Qternmet XR

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There is no generic product of Qternmet XR.

Qternmet XR Information

Qternmet XR at CanadaPharmacyOnline.com

The manufacturer of Qternmet XR is AstraZeneca, and it is available in several countries worldwide, including Canada. This medication was the first oral "triple-therapy" treatment for type 2 diabetes, combining three distinct blood-sugar-lowering agents into a single extended-release tablet.

The generic Dapagliflozin/Saxagliptin/Metformin Hydrochloride is currently unavailable (at this pharmacy).

Dosage:

Qternmet XR is available in several strengths of extended-release tablets:
• 2.5 mg dapagliflozin / 2.5 mg saxagliptin / 1000 mg metformin
• 5 mg dapagliflozin / 2.5 mg saxagliptin / 1000 mg metformin
• 5 mg dapagliflozin / 5 mg saxagliptin / 1000 mg metformin
• 10 mg dapagliflozin / 5 mg saxagliptin / 1000 mg metformin

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Qternmet XR is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It is particularly indicated for patients who are already taking metformin and require additional help reaching their blood sugar (HbA1c) goals. Combining three medications into a single pill simplifies the complex treatment plan.

It is important to note that Qternmet XR is not for the treatment of type 1 diabetes or diabetic ketoacidosis. Because it contains extended-release metformin, the tablet shell may occasionally appear in the stool; this is normal and does not mean the medication was not absorbed.

Mechanism of Action
Qternmet XR employs three complementary pathways to manage blood glucose levels, targeting the kidneys, the pancreas, and the liver simultaneously. Dapagliflozin is an SGLT2 inhibitor that works in the kidneys to block the reabsorption of glucose back into the bloodstream, allowing excess glucose to be excreted in the urine. Saxagliptin is a DPP-4 inhibitor that prevents the breakdown of incretin hormones. This signals the pancreas to produce more insulin when blood sugar is high and tells the liver to stop producing unnecessary sugar. Finally, metformin is a biguanide that reduces the amount of glucose the liver produces and improves the body's sensitivity to insulin, allowing cells to use existing sugar more effectively. Together, these three mechanisms provide a powerful, multi-pronged approach to diabetes management.

Take Qternmet XR exactly as your doctor prescribes, following the instructions in the product monograph. Consult your doctor for personalized guidance and safe use. Take the tablets once daily in the morning with food and swallow them whole. Do not stop taking it or change your dose without consulting your doctor, as this can lead to dangerous spikes in blood sugar.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Qternmet XR, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Qternmet XR (dapagliflozin/saxagliptin/metformin hydrochloride). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Qternmet XR; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or nausea
• Dyslipidemia (abnormal levels of fats in the blood)
• Genital yeast infections
• Headache
• Upper respiratory tract infections (runny nose, sore throat)
• Urinary tract infections (UTIs)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Fournier's Gangrene: Pain, redness, or swelling in the genital or anal area accompanied by fever.
• Heart Failure: Increasing shortness of breath, sudden weight gain, or swelling in the feet and ankles.
• Ketoacidosis: Difficulty breathing, nausea, vomiting, or stomach pain (can occur even if blood sugar is not very high).
• Lactic Acidosis: A rare but life-threatening buildup of acid in the blood caused by metformin. Symptoms include feeling very weak, unusual muscle pain, trouble breathing, or feeling cold in the hands and feet.
• Pancreatitis: Severe pain in the upper stomach that may spread to the back, with or without vomiting.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Qternmet XR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Qternmet XR/dapagliflozin/saxagliptin/metformin hydrochloride if:
• Allergies: You have a known hypersensitivity to dapagliflozin, saxagliptin, or metformin.
• Kidney Problems: You have severe kidney disease or are on dialysis.
• Metabolic Acidosis: You have acute or chronic metabolic acidosis, including diabetic ketoacidosis.
• Type 1 diabetes

Tell your doctor about all of your medical conditions, past and present, before starting Qternmet XR. This is crucial as certain conditions affect the drug's safety.
• Alcoholism: Excessive alcohol use increases the risk of lactic acidosis.
• Heart or Liver Disease: Conditions that increase the risk of lactic acidosis or heart failure.
• Upcoming Procedures: You may need to stop taking the medication temporarily before surgery or X-ray procedures involving iodinated contrast dye.

Drug Interactions:

Before taking Qternmet XR, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/210874s000lbl.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Qternmet XR. Qternmet XR may interact with other medicines, including but not limited to:
• Carbonic Anhydrase Inhibitors: Such as topiramate, which may increase the risk of lactic acidosis.
• Insulin or Insulin Secretagogues: Taking these with Qternmet XR may increase the risk of hypoglycemia (low blood sugar).
• Strong CYP3A4/5 Inhibitors: Drugs such as ketoconazole or ritonavir can significantly increase saxagliptin levels.

Pregnancy and Breastfeeding:

Qternmet XR is not recommended during the second and third trimesters of pregnancy, as it may affect the development of the baby's kidneys. It is unknown if the medication passes into breast milk; however, due to potential risks to the infant, breastfeeding while taking this medication is generally discouraged. Inform your doctor if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

Use in Children:

The safety and effectiveness of Qternmet XR in pediatric patients under 18 years of age have not been established.

Frequently Asked Questions about Qternmet XR at Canada Pharmacy Online

Why is Qternmet XR more affordable in Canada than in the United States?

Prescription drug prices, including Qternmet XR, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Qternmet XR I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Qternmet XR per prescription from your doctor.

Can I buy Qternmet XR from you over the counter?

No, Qternmet XR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Qternmet XR?

No, the generic Dapagliflozin/Saxagliptin/Metformin Hydrochloride is not available.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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