Repatha (Evolocumab)

Name: Repatha
Brand: Amgen
SKU: 7075
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Repatha Auto Pen Injection (Box of 2) LOCAL PICK ONLY

Manufacturer: Amgen

Country: Canada

Dosage: 140 mg/1 ml

Qty-Price (USD):

Type:

Product: Repatha Mini-Doser (1 unit per Pack) LOCAL PICK ONLY

Manufacturer: Amgen

Country: Canada

Dosage: 420 mg/3.5 ml

Qty-Price (USD):

Generic Equivalent of Repatha

Type

Product

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Qty-Price (USD)

There is no generic product of Repatha.

Repatha Information

medically reviewed by Carol Hou (BSc. Pharm) on December 17, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Repatha at CanadaPharmacyOnline.com

Repatha (evolocumab) is manufactured and marketed by Amgen in Canada.

Generic evolovumab is currently unavailable (at this pharmacy).

Dosage:

Repatha is available in the following dosage forms and strengths:
• Solution/prefilled syringe and autoinjector: contains 140 mg evolocumab, proline, glacial acetic acid, polysorbate 80, water for injection, and sodium hydroxide
• Automated mini-doser with prefilled cartridge: 120 mg/mL contains 420 mg evolocumab (120 mg/mL), proline, glacial acetic acid, polysorbate 80, water for injection, and sodium hydroxide.

This medication is available for Local Pick Up Only. We require a valid prescription from your physician for all prescription medications.

Your doctor will determine the appropriate dose based on your individual needs and medical history.

Usage:

Repatha (evolocumab) is an injectable medication mainly used in adults to achieve a significant, ongoing reduction in "bad cholesterol" (LDL-C) and to decrease the risk of serious events like heart attack, stroke, and the need for coronary revascularization in patients with established cardiovascular disease (CVD).

It is prescribed along with diet and often combined with other cholesterol-lowering drugs, such as statins, for those who need more aggressive LDL-C control or who cannot tolerate statins. Repatha is also specifically approved for adults and pediatric patients aged 10 years and older who have the severe, inherited conditions known as Heterozygous Familial Hypercholesterolemia (HeFH) or Homozygous Familial Hypercholesterolemia (HoFH).

Mechanism of Action:
Repatha works as a "PCSK9 inhibitor" to help your liver naturally clear more bad cholesterol (LDL-C) from your blood. In a normal cycle, your liver uses specialized receptors to grab cholesterol from the bloodstream; however, a protein called PCSK9 often attaches to these receptors and sends them to the "trash compactor" of the cell (the lysosome) to be destroyed.

Repatha acts like a shield by blocking the PCSK9 protein before it can do its damage. This allows your liver’s receptors to be recycled back to the surface instead of being thrown away. With more of these "filters" active and available on the liver’s surface, your body can much more effectively pull excess cholesterol out of your blood, significantly lowering your levels and reducing the risk of heart attack or stroke.

Take Repatha exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Repatha, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Repatha, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common Side Effects – The following are common side effects of Repatha; other side effects may occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Arthralgia (joint pain)
• Back pain
• Influenza (flu-like symptoms, e.g., fever, body aches, or chills)
• Headache
• Injection site reactions (including pain, redness, or bruising at the site of the injection)
• Nasopharyngitis (symptoms of a common cold, such as a runny nose or sore throat)
• Upper respiratory tract infection (including the common cold)
• Urinary Tract Infection (UTI)

Other Potential Side Effects (less common):
• Diarrhea
• Dizziness
• Myalgia (muscle pain)
• Nausea

Serious Side Effects: These are rare but potentially severe. Seek immediate medical attention or call emergency services if you experience any of the following:
• Angioedema (swelling of the face, lips, tongue, or throat)
• Anaphylaxis (a life-threatening whole-body allergic reaction)
• Difficulty breathing or swallowing
• Hives or a severe rash

Note: The needle cover on the Repatha prefilled syringe and SureClick autoinjector contains dry natural rubber, a derivative of latex. If you have a known latex allergy, inform your healthcare provider, as this could increase your risk of an allergic reaction.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Repatha, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Repatha/evolocumab if:
• You have a known allergy or hypersensitivity to evolocumab or to any of the inactive ingredients (including a history of a severe reaction like angioedema or anaphylaxis).

Important Safety Information
• Latex Warning: The needle cover on the Repatha prefilled syringe and the SureClick autoinjector contain dry natural rubber, which is a derivative of latex. If you have a known latex allergy, tell your healthcare provider before using this medication, as it may cause an allergic reaction.

Tell your doctor about all of your medical conditions, past and present, before starting Repatha, including:
• Current Medications: Ensure you mention if you are taking other cholesterol-lowering drugs (like statins) or newer "FcRn blockers" used for autoimmune conditions, as these can affect how Repatha works in your system.
• Latex or Rubber Allergy: This is a critical point because the needle cover on the prefilled syringes and autoinjectors contains dry natural rubber (a latex derivative), which can cause reactions in sensitive individuals.
• Liver or Kidney Problems: While Repatha is generally safe for these patients, your doctor should be aware of any history of severe hepatic (liver) or renal (kidney) impairment to monitor your overall health.

Drug Interactions:

Before taking Repatha, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official product monograph from Amgen Canada at https://www.amgen.ca/about/-/media/themes/corporateaffairs/redesign/amgen-ca/amgen-ca/pdf/products/en/en-repatha-pm.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Repatha.

Repatha has a minimal drug interaction profile. The following items are noted:

1. Interactions with Other Cholesterol Medications:
• Statins and Ezetimibe: Repatha is specifically designed to be used alongside other cholesterol-lowering treatments, such as statins or ezetimibe. These combinations are considered safe and highly effective for lowering "bad" cholesterol. No dose adjustments are needed when taking these medications together.
• Other Lipid-Lowering Drugs (e.g., Fibrates, Niacin): No significant drug-drug interactions are known with other non-statin lipid-lowering medications.

2. Other Known Interactions (Moderate Risk):
• FcRn Blockers (Other Monoclonal Antibodies): Concomitant use with certain drugs that block the neonatal Fc Receptor (FcRn) (e.g., efgartigimod alfa, nipocalimab, rozanolixizumab) may decrease Repatha’s plasma concentration and therapeutic effect. Your doctor must carefully monitor the timing and dosage if these treatments are used together.

3. Food, Alcohol, Supplements, and Cannabis:
• Repatha is not metabolized by the major enzyme system (CYP450) that typically causes drug-food interactions. There are no known interactions with food, alcohol, cannabis/CBD, vitamins, or herbal supplements.

Pregnancy and Breastfeeding:

Repatha (evolocumab) is generally not recommended during pregnancy or while breastfeeding due to limited human data on its safety for the developing baby or nursing infant. As Repatha is a large IgG monoclonal antibody, it is expected to cross the placenta, particularly during the second and third trimesters. While it may be excreted into breast milk, the amount absorbed by the infant's GI tract is likely to be very low. Therefore, doctors prescribe Repatha only when the significant benefits for the mother's cholesterol management clearly outweigh the uncertain risks to the baby.

Pregnancy Exposure Registry: Patients who become pregnant while receiving Repatha are strongly encouraged to enroll in the manufacturer's Pregnancy Exposure Registry to help monitor outcomes.

Pediatric Use of Repatha

Repatha (evolocumab) is approved for use in children with specific, inherited high-cholesterol conditions. The age limits depend on the type of genetic condition being treated:
• Heterozygous Familial Hypercholesterolemia (HeFH): Repatha is approved for pediatric patients 10 years of age and older. In these children, it is used alongside diet and other cholesterol-lowering therapies to reduce LDL-C levels.
• Homozygous Familial Hypercholesterolemia (HoFH): Repatha is approved for pediatric patients 10 years of age and older. Because HoFH is a more aggressive form of the disease, Repatha is often started as early as possible to prevent premature heart disease.

How it is used in children: In both conditions, Repatha is prescribed as an add-on therapy. It is used in combination with a low-fat diet and other lipid-lowering treatments (such as statins or ezetimibe) when those treatments alone are not enough to reach healthy cholesterol targets.

Safety Note for Parents: The safety and effectiveness of Repatha have not been established in pediatric patients with "common" high cholesterol that is not caused by these specific genetic conditions. Always consult a pediatric lipid specialist for personalized dosing and monitoring.

Frequently Asked Questions about Repatha at Canada Pharmacy Online:

Why is Repatha more affordable in Canada than in the United States?

Prescription drug prices, including Repatha, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Repatha?

No, there is no generic available for this product.

Can my child take Repatha?

Do not give Repatha to a child without specific medical advice.

Repatha (evolocumab) is not approved for use in children younger than 10 years old. For pediatric patients aged 10 years and older, its use is strictly limited to the treatment of severe, inherited conditions: Heterozygous Familial Hypercholesterolemia (HeFH) or Homozygous Familial Hypercholesterolemia (HoFH). It is not approved for general cholesterol management in children.

What should I avoid while taking Repatha?

Avoid injecting Repatha into skin that is bruised, sore, scarred, hardened, or tattooed. Choose a different site (thigh, abdomen, or upper arm) for each injection.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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