Simparica Trio (Pyrantel/Sarolaner/Moxidectin)

Name: Simparica Trio
Brand: Zoetis
SKU: 7784
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Simparica Trio 6 Chewable Tablets (1.3 to 2.5 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 12.5 mg/3 mg/0.06 mg

Qty-Price (USD):

Type:

Product: Simparica Trio Chewable Tab for Dogs (>1.25-2.5kg)

Manufacturer: Zoetis

Country: United Kingdom

Dosage: 12.5 mg/3 mg/0.06 mg/3 tabs

Qty-Price (USD):

Type:

Product: Simparica Trio 6 Chewable Tablets (2.6 to 5 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 25 mg/6 mg/0.12 mg

Qty-Price (USD):

Type:

Product: Simparica Trio Chewable Tab for Dogs (>2.5-5kg)

Manufacturer: Zoetis

Country: United Kingdom

Dosage: 25 mg/6 mg/0.12 mg/3 tabs

Qty-Price (USD):

Type:

Product: Simparica Trio 6 Chewable Tablets (5.1 to 10 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 50 mg/12 mg/0.24 mg

Qty-Price (USD):

Type:

Product: Simparica Trio Chewable Tab for Dogs (>5.0-10kg)

Manufacturer: Zoetis

Country: United Kingdom

Dosage: 50 mg/12 mg/0.24 mg/3 tabs

Qty-Price (USD):

Type:

Product: Simparica Trio 6 Chewable Tablets (10.1 to 20 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 100 mg/24 mg/0.48 mg

Qty-Price (USD):

Type:

Product: Simparica Trio Chewable Tab for Medium Dogs (10.1-20 KG)

Manufacturer: Zoetis

Country: Australia

Dosage: 100 mg/24 mg/0.48 mg/6 tabs

Qty-Price (USD):

Type:

Product: Simparica Trio 6 Chewable Tablets (20.1 to 40 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 200 mg/48 mg/0.96 mg

Qty-Price (USD):

Type:

Product: Simparica Trio 6 Chewable Tablets (40.1 to 60 kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 300 mg/72 mg/1.44 mg

Qty-Price (USD):

Type:

Product: Simparica Trio Chewable Tab for Dogs (>40.1 to 60kg)

Manufacturer: Zoetis

Country: United Kingdom

Dosage: 300 mg/72 mg/1.44 mg/ 3 tabs

Qty-Price (USD):

Generic Equivalent of Simparica Trio

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no generic product of Simparica Trio.

Simparica Trio Information

Simparica Trio at CanadaPharmacyOnline.com

Simparica Trio is a brand of prescription-only veterinary medicine manufactured by Zoetis. It is available in numerous countries, including Canada and the United Kingdom, and is manufactured by Zoetis.

The generic version is currently unavailable (at this pharmacy).

Dosage

Simparica Trio is a chewable tablet formulated to provide a minimum dose of three active ingredients: sarolaner, moxidectin, and pyrantel (as pamoate salt). The tablets are available in six different strengths, each corresponding to a specific weight range for dogs.
• 1.3–2.5 kg (2.8–5.5 lbs): 3 mg sarolaner / 0.06 mg moxidectin / 12.5 mg pyrantel
• 2.6–5.0 kg (5.6–11.0 lbs): 6 mg sarolaner / 0.12 mg moxidectin / 25 mg pyrantel
• 5.1–10.0 kg (11.1–22.0 lbs): 12 mg sarolaner / 0.24 mg moxidectin / 50 mg pyrantel
• 10.1–20.0 kg (22.1–44.0 lbs): 24 mg sarolaner / 0.48 mg moxidectin / 100 mg pyrantel
• 20.1–40.0 kg (44.1–88.0 lbs): 48 mg sarolaner / 0.96 mg moxidectin / 200 mg pyrantel
• 40.1–60.0 kg (88.1–132.0 lbs): 72 mg sarolaner / 1.44 mg moxidectin / 300 mg pyrantel

Your veterinarian determines the dosage based on your dog's weight.

Usage

Simparica Trio is a combination product used for a broad range of parasitic threats in dogs and puppies 8 weeks of age and older, and weighing at least 1.25 kg (2.8 lbs). It is indicated for:
• Flea and Tick Infestations.
• Kills adult fleas (Ctenocephalides felis) and is indicated for the treatment and prevention of flea infestations.
• Indicated for the treatment and control of several species of ticks.
• Helps prevent Lyme disease (caused by Borrelia burgdorferi) by killing the deer tick vector (Ixodes scapularis).
• Heartworm Disease Prevention: Caused by Dirofilaria immitis.
• Intestinal Parasitic Infections.
• Treatment and control of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) infections.
• Treatment and control of hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections.

Mechanism of Action
Simparica Trio contains three active ingredients, each with a different mechanism of action to provide comprehensive protection:
• Moxidectin: A macrocyclic lactone that interferes with chloride channels in parasitic nematodes (worms), disrupting nerve signal transmission. This leads to paralysis and death of the parasites. Moxidectin is the primary ingredient responsible for heartworm prevention.
• Pyrantel Pamoate: A tetrahydropyrimidine-class anthelmintic that acts as a depolarizing neuromuscular blocking agent in roundworms and hookworms. It causes spastic paralysis of the worms, leading to their expulsion from the dog's body.
• Sarolaner: An isoxazoline-class insecticide and acaricide that works by inhibiting the function of GABA and glutamate-gated chloride channels in the nervous system of fleas and ticks. This leads to uncontrolled neuromuscular activity, paralysis, and death of the parasites.

Administer Simparica Trio exactly as your veterinarian prescribes, following the instructions on the official product label | Zoetis. Consult your veterinarian for personalized guidance and safe use of this product.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before giving Simparica Trio to your dog, it is essential to discuss all possible side effects, risks, and interactions with your veterinarian.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Simparica Trio, it is crucial to discuss potential side effects and risks with your veterinarian.

Common Side Effects - The following are some common side effects of Simparica Trio; other side effects may also occur. Contact your veterinarian promptly if any side effects are persistent, worsening, or concerning, or if your dog experiences any other concerning symptoms.
• Anorexia (loss of appetite)
• Diarrhea (with or without blood)
• Lethargy
• Vomiting

Serious Side Effects - These are rare but potentially severe side effects. Seek immediate veterinary attention if you observe any of the following:
• Hypersensitivity reactions: Although rare, allergic reactions, such as severe rash, hives, swelling, or difficulty breathing, can occur.
• Neurological signs: Sarolaner, a component of Simparica Trio, belongs to the isoxazoline class of drugs, which has been associated with neurological adverse reactions. These may include muscle tremors, ataxia (uncoordinated movements), and seizures, even in dogs without a history of neurological disorders. Use with caution in dogs with a history of seizures.
• Pre-existing Heartworm Infection: Before starting Simparica Trio, dogs should be tested for existing heartworm infections. Simparica Trio is not effective against adult heartworms (Dirofilaria immitis). Dogs infected with adult heartworms should be treated with an adulticide to remove them, as microfilariae (immature heartworms) may be present. While Simparica Trio has been shown to reduce microfilariae, its effect on adult worms is limited.

Administering Simparica Trio to a dog with a high number of circulating microfilariae may result in a severe, potentially fatal, hypersensitivity reaction.

Contraindications

The following is not an exhaustive list of contraindications. Before starting Simparica Trio, it is essential to discuss all your dog's medical conditions, past and present, as well as all medications you are currently administering, with your veterinarian.

Simparica Trio should not be used if:
• Your dog has a known hypersensitivity to sarolaner, moxidectin, pyrantel, or any of the other ingredients in this product.

Tell your veterinarian about all of your dog's medical conditions, past and present, before starting Simparica Trio. This is crucial because certain conditions affect whether Simparica Trio is right for your dog. These conditions may include, but are not limited to:
• A history of seizures or other neurological disorders.
• Any existing heartworm infection. Dogs should be tested for heartworm disease before starting a preventative treatment.

Drug Interactions

Before giving Simparica Trio, it is essential to discuss all potential risks and interactions with your veterinarian. For complete and up-to-date information, refer to the official package insert for Simparica Trio.

Provide your veterinarian with a complete list of all medications, supplements, and other products your dog is taking. In clinical studies, Simparica Trio was safely used with commonly prescribed vaccines, parasiticides, and other medications. While there are no known drug-to-drug interactions, macrocyclic lactones (like moxidectin) are substrates for P-glycoprotein. Therefore, caution should be used when administering Simparica Trio with other medications that can inhibit P-glycoprotein.

Pregnancy and Lactation
The safety of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Therefore, the use of this product in these animals is not recommended. Consult your veterinarian for alternative options if your dog is pregnant, lactating, or intended for breeding.

Frequently Asked Questions about Simparica Trio at Canada Pharmacy Online:

Why is Simparica Trio more affordable in Canada than in the United States?

Veterinary prescription drug prices, including Simparica Trio, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of tablets I can order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Simparica Trio at a time, as per your veterinarian's prescription.

Can I buy over the counter from you?

No, Simparica Trio requires a valid prescription from a licensed veterinarian. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

What should I do if I miss a dose?

If a monthly dose is missed, give Simparica Trio immediately and resume the monthly dosing schedule. It is essential to continue monthly dosing year-round for continuous protection.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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