Simparica (Sarolaner)

Name: Simparica
Brand: Zoetis
SKU: 7791
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Simparica 3 Chewable Tablets (1.3 to 2.5 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 5 mg

Qty-Price (USD):

Type:

Product: Simparica 3 Chewable Tablets (2.6 to 5 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 10 mg

Qty-Price (USD):

Type:

Product: Simparica 3 Chewable Tablets (5.1 to 10 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 20 mg

Qty-Price (USD):

Type:

Product: Simparica 3 Chewable Tablets (10.1 to 20 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 40 mg

Qty-Price (USD):

Type:

Product: Simparica 3 Chewable Tablets (20.1 to 40 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 80 mg

Qty-Price (USD):

Type:

Product: Simparica 3 Chewable Tablets (40.1 to 60 Kg Dog)

Manufacturer: Zoetis

Country: Canada

Dosage: 120 mg

Qty-Price (USD):

Generic Equivalent of Simparica

Type

Product

Manufacturer

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Qty-Price (USD)

There is no generic product of Simparica.

Simparica Information

medically reviewed by Carol Hou (BSc. Pharm) on November 14, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Simparica and Sarolaner at CanadaPharmacyOnline.com

The brand Simparica is manufactured by Zoetis in Canada.

There is currently no approved generic equivalent for Simparica (sarolaner) available on the market.

Dosage:

Simparica is commonly available as chewable tablets in six strengths, and each strength corresponds to a specific dog weight range:
• 5 mg (for dogs 1.3 to 2.5 Kg)
• 10 mg (for dogs 2.6 to 5 Kg)
• 20 mg (for dogs 5.1 to 10 Kg)
• 40 mg (for dogs 10.1 to 20 Kg)
• 80 mg (for dogs 20.1 to 40 Kg)
• 120 mg (for dogs 40.1 to 60 kg)

Simparica is typically sold in 3-dose (3-month) packs, but availability can vary.

Your veterinarian determines the dosage based on your dog’s weight.

Usage:

Simparica (Sarolaner) is a once-a-month chewable tablet used in dogs that are 8 weeks of age and older and weigh at least 1.3 kg (2.8 lbs). It provides immediate and persistent killing activity for at least 5 weeks against fleas and the four most common tick species.

• Fleas (Ctenocephalides felis)
• Ticks: Amblyomma americanum (Lone Star Tick), Dermacentor variabilis (American Dog Tick), Ixodes scapularis (Black-legged or Deer Tick), and Rhipicephalus sanguineus (Brown Dog Tick).
• Mites/Mange:
o Ear Mites (Otodectes cynotis)
o Sarcoptic Mange (Scabies caused by Sarcoptes scabiei)
o Demodex Mange (Demodex canis)

Mechanism of Action
Simparica's active ingredient, sarolaner, works by disrupting the nervous systems of external parasites, including fleas, ticks, and mites. After the dog takes the chewable tablet, sarolaner is absorbed into the bloodstream. When a parasite feeds on the dog, it ingests the drug, which then blocks the function of ligand-gated chloride channels (those controlled by GABA and glutamate) in the parasite's body. These receptors are essential for calming the parasite's nervous system; by blocking them, sarolaner causes uncontrolled hyperexcitation, leading to tremors, paralysis, and quick parasite death.

Administer Simparica exactly as your veterinarian prescribes, following the instructions in the official prescribing information from Zoetis. Consult your veterinarian for personalized guidance and safe use of this product.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before giving Simparica to your dog, it is essential to discuss all possible side effects, risks, and interactions with your veterinarian.

Side Effects

The information below is a partial list of side effects; individual reactions can vary. Before starting Simparica, it is crucial to discuss potential side effects and risks with your veterinarian.

Common Side Effects – The following are some common side effects of Simparica; other side effects may also occur. Contact your veterinarian promptly if any side effects persist, worsen, or concern you, or if your dog exhibits any other concerning symptoms.
• Diarrhea
• Decreased appetite (anorexia)
• Lethargy (tiredness)
• Vomiting

Serious Side Effects – These are rare but potentially severe side effects. Seek immediate veterinary attention if you observe any of the following:
• Ataxia (lack of coordination, difficulty walking)
• Seizures
• Tremors

Contraindications

The following is not an exhaustive list of contraindications. Before starting Simparica, it is essential to discuss all your dog’s medical conditions, past and present, as well as all medications you are currently administering, with your veterinarian.

Simparica should not be used in:
• Cats.
• Dog with known hypersensitivity (allergy) to sarolaner or any other ingredient in the tablet.
• Dogs less than six months old.
• Dogs weighing less than 2.8 pounds (1.3kg).

Inform your veterinarian about all of your dog’s current and past medical conditions before starting Simparica. This is crucial because certain conditions affect whether Simparica is right for your dog. These conditions may include, but are not limited to:
• A history of neurologic disorders (e.g., seizures, epilepsy).

Drug Interactions

Before giving Simparica, it is essential to discuss all potential risks and interactions with your veterinarian. For complete and up-to-date information, please visit the package insert from Zoetis.
• High protein binding drugs (Potential Risk): The active ingredient, sarolaner, is highly bound to plasma proteins (more than 99.9%). In theory, it might compete with other highly protein-bound medications, potentially affecting the levels of either drug.
Examples of highly bound drugs that might compete (theoretical):
o Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
o The coumarin derivative Warfarin
• Neurologic Agents: While not a direct interaction, Simparica is in the isoxazoline class, which can rarely cause neurologic signs (tremors, seizures). Veterinarians are cautioned to use Simparica carefully in dogs with a history of seizure disorders, but this is a precaution based on class risk, not a confirmed drug interaction.

Pregnancy and Lactation

The safety of Simparica has not been established in breeding, pregnant, or lactating dogs; therefore, it is not recommended for these dogs on a routine basis. Consult your veterinarian for alternative options if your dog is pregnant, lactating, or intended for breeding.

Frequently Asked Questions about Simparica at Canada Pharmacy Online:

Why is Simparica more affordable in Canada than in the United States?

Veterinary prescription drug prices, including Simparica, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on the number of Simparica tablets I can order at once?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Simparica at one time, per your veterinarian's prescription.

Can I buy Simparica over the counter from you?

No, Simparica requires a valid prescription from your veterinarian. We do not sell this product without a prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days for your order to be delivered from our pharmacy.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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