Spravato (Esketamine)

Name: Spravato
Brand: Janssen
SKU: 7562
Availability: InStock

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Type:

Product: Spravato Nasal Spary (CURRENTLY UNAVAILABLE)

Manufacturer: Janssen

Country: Canada

Dosage:

Qty-Price (USD):

Generic Equivalent of Spravato

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There is no generic product of Spravato.

Spravato Information

Spravato and Esketamine at CanadaPharmacyOnline.com

The manufacturer of Spravato (esketamine) is Janssen Pharmaceuticals, a division of Johnson & Johnson. Spravato is a groundbreaking, FDA- and Health Canada-approved treatment specifically developed for adults with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation. Because Spravato is a controlled substance with a unique administration protocol, it is primarily available through restricted distribution programs (such as the REMS program in the US).

The brand and generic Spravato are currently unavailable (at this pharmacy).

Dosage:

Spravato is available in a unique delivery system:
• Nasal Spray Device: Each single-use device delivers 28 mg of esketamine (two sprays, one per nostril).

Your doctor will determine the appropriate dose based on your individual needs and medical conditions. A treatment session typically involves using either 2 devices (56 mg) or 3 devices (84 mg). Older adults typically start at 56 mg due to tolerability considerations. Treatment usually begins with twice-weekly sessions for the first month, eventually tapering to once weekly or every other week during the maintenance phase.

Usage:

Spravato is prescribed for adults who have not found relief from at least two different antidepressant medications (Treatment-Resistant Depression). While Spravato treats the symptoms of depression in adults with suicidal ideation, it has not been proven to prevent suicide. Patients in an immediate crisis still require standard emergency psychiatric care. It is essential to understand that Spravato is not used as a standalone treatment. Take it alongside a newly started or ongoing oral antidepressant. Because the medication can cause temporary "out-of-body" experiences or a spike in blood pressure, patients must remain in the doctor's office for at least 2 hours of observation after each dose.

Mechanism of Action

Esketamine, the active component in Spravato, works differently from traditional antidepressants like SSRIs or SNRIs. While older drugs target serotonin, norepinephrine, or dopamine, Spravato targets the glutamate system, the brain's most abundant neurotransmitter. Specifically, it acts as a non-competitive NMDA receptor antagonist. Blocking these receptors triggers a surge in glutamate, which then activates AMPA receptors. This process stimulates the production of brain-derived neurotrophic factor (BDNF), which helps promote synaptic plasticity and functional connectivity (synapses) in areas of the brain responsible for mood and emotional regulation. This rapid restoration of brain plasticity is what allows for the fast-acting relief of severe depressive symptoms.

Spravato must be administered in a certified healthcare setting, according to the product monograph. Do not attempt to use this medication at home. You must arrange for a driver to take you to and from your appointments, as you cannot drive or operate machinery until the next day after a restful sleep. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Spravato, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Spravato (esketamine). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Spravato; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Dissociation (feeling "spaced out" or disconnected from reality)
• Dizziness and nausea
• Increased blood pressure
• Sleepiness or sedation
• Metallic taste in the mouth

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Bladder Problems: Rare urinary symptoms have been reported, particularly with prolonged or repeated exposure.
• Hypertensive Crisis: A dangerous spike in blood pressure.
• Severe Dissociation: Intense feelings of detachment that do not fade.
• Worsening Depression: Any sudden changes in mood or suicidal thoughts.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Spravato, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Spravato/esketamine if:
• Allergies: You are allergic to esketamine or ketamine.
• History of Intracerebral Hemorrhage: You have had a "bleeding" stroke in the past.
• Uncontrolled hypertension
• Vascular Disease: You have a history of aneurysms (brain, chest, or abdominal) or an arteriovenous malformation.

Tell your doctor about all of your medical conditions, past and present, before starting Spravato. This is crucial as certain conditions affect the drug's safety.
• Heart Problems: High blood pressure, heart valve disease, or a recent heart attack.
• History of Substance Abuse: As a controlled substance, Spravato has the potential for misuse.
• Liver Disease: Impaired liver function can affect how the drug is cleared from the body.

Drug Interactions:

Before taking Spravato, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the prescribing information at https://www.jnjlabels.com/package-insert/product-monograph/prescribing-information/SPRAVATO-pi.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Spravato. Spravato may interact with other medicines, including but not limited to:
• Benzodiazepines & Opioids: These can increase the risk of profound sedation.
• Stimulants: May further increase blood pressure when combined with esketamine.
• MAOIs: Use caution, as this combination can lead to dangerous blood pressure levels

Pregnancy and Breastfeeding:

Spravato is not recommended during pregnancy, as it may cause fetal harm. Women of childbearing age should use effective contraception during treatment. Avoid breastfeeding while using this medication. Inform your doctor if you are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed.

Use in Children:

The safety and effectiveness of Spravato in pediatric patients (under 18 years of age) have not been established.

Frequently Asked Questions about Spravato at Canada Pharmacy Online

Why is Spravato more affordable in Canada than in the United States?

Prescription drug prices, including Spravato, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Can I buy Spravato from you over the counter?

No, Spravato requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Spravato?

No, the generic esketamine is currently unavailable (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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