Synjardy XR (Empagliflozin/Metformin Hydrochloride)

Name: Synjardy XR
Brand: Generic
SKU: 7827
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Synjardy XR.

Generic Equivalent of Synjardy XR

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Empagliflozin/Metformin Hydrochloride Extended Release Tablet

Manufacturer: Generic

Country: India

Dosage: 12.5 mg/1000 mg

Qty-Price (USD):

Synjardy XR Information

Synjardy XR at CanadaPharmacyOnline.com

Synjardy XR combines empagliflozin, the active ingredient in Jardiance, with extended-release metformin. Boehringer Ingelheim manufactures it. The brand Synjardy XR is currently unavailable (at this pharmacy).

The generic empagliflozin/metformin hydrochloride extended-release tablet is available and bioequivalent to the brand-name combination.

Dosage:

Empagliflozin/metformin extended-release tablets are available in the following oral strength:
• Extended-Release Tablets: 12.5 mg/1000 mg.

Synjardy XR is typically taken once daily in the morning with a meal. Swallow tablets whole; do not split or crush, since breaking them can release the full dose at once and increase the risk of side effects. Your doctor will determine your starting dose and may adjust it gradually based on your blood sugar control and kidney function.

Usage:

Synjardy XR is used, along with diet and exercise, to improve blood sugar control in adults with type 2 diabetes. Empagliflozin, one of its two active ingredients, may also help reduce the risk of cardiovascular death in adults with type 2 diabetes and known heart disease.

Mechanism of Action
Synjardy XR works through two complementary mechanisms. Empagliflozin belongs to a class of medications called SGLT2 inhibitors; it blocks a protein in the kidneys that reabsorbs glucose back into the blood, so excess glucose is instead removed through the urine. Metformin, the second ingredient, reduces the amount of glucose produced by the liver and improves the body's sensitivity to insulin, while modestly reducing the amount of sugar absorbed from the intestines. Together, these actions lower blood sugar through different pathways.

Take Synjardy XR exactly as your doctor prescribes, according to the highlights of the prescribing information. It is important to continue taking Synjardy XR even after your blood sugar improves, since stopping the medication can allow blood sugar levels to rise again.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Synjardy XR, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Synjardy XR (empagliflozin/metformin). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Synjardy XR; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Diarrhea or nausea
• Increased urination
• Urinary tract or genital yeast infections

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Diabetic Ketoacidosis: Nausea, vomiting, stomach pain, and unusual fatigue, even with blood sugar levels that are not extremely high.
• Fournier’s Gangrene (Necrotizing Fasciitis): A rare, severe infection in the genital or rectal area. Seek immediate emergency care if you develop fever accompanied by severe pain, tenderness, redness, or swelling in the genital or perineal area.
• Lactic Acidosis: Unusual weakness or tiredness, unusual muscle pain, trouble breathing, feeling cold, or stomach discomfort with nausea and vomiting; this is a rare but serious complication of metformin.
• Signs of Dehydration or Low Blood Pressure: Dizziness or lightheadedness, especially upon standing.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Synjardy XR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Synjardy XR if:
• Allergies: You have a known hypersensitivity to empagliflozin, metformin, or any of the tablet's ingredients.
• Severe Kidney Impairment (eGFR less than 30 mL/min/1.73 m²) or Metabolic Acidosis, Including Diabetic Ketoacidosis.
Tell your doctor about all of your medical conditions, past and present, before starting Synjardy XR. This is crucial as certain conditions affect the drug's safety.
• A History of Pancreatitis or Pancreatic Surgery.
• Heavy Alcohol Use.
• Liver Disease.
• Moderate Kidney Impairment (eGFR 30 to 45 mL/min/1.73 m², as starting the medication is generally not recommended in this range).

Drug Interactions:

Before taking Synjardy XR, discuss all potential risks and interactions with your doctor or pharmacist. For complete, up-to-date information, please refer to the consumer information at https://hpr-rps.hres.ca/details.php?drugproductid=2436.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Synjardy XR. Synjardy XR may interact with other medicines, including but not limited to:
• Diuretics: These may increase the risk of dehydration and low blood pressure when combined with Synjardy XR.
• Insulin or Sulfonylureas: Combining these with Synjardy XR can increase the risk of low blood sugar (hypoglycemia).
• Iodinated Contrast Agents Used in Imaging: Metformin should generally be paused around the time of these procedures due to a risk of kidney problems and lactic acidosis.

Pregnancy and Breastfeeding:

Do not take Synjardy XR during the second or third trimester of pregnancy due to potential risks to fetal kidney development. Small amounts of metformin can pass into breast milk, while it is not yet known whether empagliflozin does the same. Tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.

Use in Children:

Synjardy XR has not been established as safe and effective for use in children, and its use in this age group is not recommended.

Frequently Asked Questions about Synjardy XR at Canada Pharmacy Online

Why is Synjardy XR more affordable in Canada than in the United States?

Prescription drug prices, including Synjardy XR, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Synjardy XR I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Synjardy XR per prescription from your doctor.

Can I buy Synjardy XR from you over the counter?

No, Synjardy XR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Synjardy XR?

Yes, the generic alternative empagliflozin/metformin hydrochloride is available.

Blog Post:

Insulin Resistance: Are You at Risk for Developing Diabetes?

Latest News:

NICE Updates First-Line Type 2 Diabetes Care (article published February 2026)

Similar Drugs in the category of Diabetic Medications and Products:

Jardiance Farxiga Rybelsus Januvia Tradjenta

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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