Synjardy (Empagliflozin/Metformin Hydrochloride)

Name: Synjardy
Brand: Boehringer Ingelheim
SKU: 7052
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 5 mg/1000 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 5 mg/850 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 12.5 mg/1000 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 12.5 mg/500 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: Canada

Dosage: 12.5 mg/850 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet

Manufacturer: Boehringer Ingelheim

Country: India

Dosage: 12.5 mg/500 mg

Qty-Price (USD):

Type:

Product: Synjardy Tablet (ON BACKORDER)

Manufacturer: Boehringer Ingelheim

Country: Turkey

Dosage: 12.5 mg/1000 mg

Qty-Price (USD):

Generic Equivalent of Synjardy

Type

Product

Manufacturer

Country

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Qty-Price (USD)

There is no generic product of Synjardy.

Synjardy Information

medically reviewed by Carol Hou (BSc. Pharm) on July 4, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Synjardy at CanadaPharmacyOnline.com

Brand Synjardy, manufactured by Boehringer Ingelheim, is available in many countries worldwide, including Canada, India, and Turkey.

The generic empagliflozin/metformin hydrochloride is currently unavailable (at this pharmacy).

Dosage:

Synjardy oral tablets come in multiple strengths, combining fixed doses of empagliflozin and metformin hydrochloride. These include: 5 mg/850 mg, 5 mg/1000 mg, 12.5 mg/500 mg, 12.5 mg/850 mg, and 12.5 mg/1000 mg.

Your doctor will determine the appropriate dosage based on the individual needs and medical conditions.

Usage:

Synjardy (empagliflozin/metformin hydrochloride) is a prescription medication used along with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Type 2 diabetes is a chronic metabolic disorder that presents with persistently high blood sugar levels. This is because the body is unable to use insulin properly or produce enough of it. Synjardy can also be used to reduce the risk of cardiovascular death, stroke, or heart failure in adults with type 2 diabetes and established heart disease.

Mechanism of Action:
Synjardy (empagliflozin/metformin hydrochloride) is a combination medication used to treat diabetes. Empagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It blocks the SGLT2 protein in the kidneys, reducing the reabsorption of glucose into the blood and increasing glucose excretion in the urine. This action lowers blood sugar levels. Metformin hydrochloride is a biguanide. It decreases glucose production by the liver, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

Take Synjardy exactly as your doctor prescribes, following the instructions in the Highlights of Prescribing Information. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Synjardy, it is essential to discuss all potential side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below is a partial list of side effects; individual reactions can vary. Before starting Synjardy, it is crucial to discuss potential side effects and risks with your doctor or pharmacist.

Common side effects – The following are examples of some common side effects of Synjardy; however, other side effects may occur. Contact your doctor promptly if any side effects persist, worsen, or concern you, or if you experience any other concerning symptoms.
• Diarrhea
• Nausea
• Vomiting
• Abdominal discomfort
• Yeast infections (in women)
• Increased urination

Serious or rare side effects – Stop taking Synjardy and seek immediate medical attention right away if you experience any of the following:
• Acute kidney injury or worsening kidney function
• Allergic reactions, including angioedema, hives, and trouble breathing
• Dehydration
• Signs of diabetic ketoacidosis, including difficulty breathing, vomiting, abdominal pain, unusual fatigue, nausea, fruity breath odor
• Signs of Fournier’s Gangrene, including severe pain, tenderness, redness, or swelling in the genital or anal area
• Signs of lactic acidosis, including stomach pain, dizziness, trouble breathing, lightheadedness, unusual muscle pain
• Urinary tract infections (UTIs)

Contraindications:

This is not an exhaustive list of contraindications. It is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist before starting Synjardy.

Synjardy should not be used if:
• Are allergic to empagliflozin/metformin hydrochloride or any of the inactive ingredients in Synjardy
• You have diabetic ketoacidosis
• You have dialysis
• You have lactic acidosis
• You have moderate or severe kidney disease
• You have Type 1 diabetes

Tell your doctor about all of your medical conditions, past and present, before starting Synjardy. This is crucial because certain conditions can affect whether Synjardy is right for you. These conditions may include, but are not limited to:
• Bladder infection
• Congestive heart failure
• Genital infection
• History of urinary tract infections (UTIs) or genital yeast infections
• Kidney disease
• Liver disease
• Low-salt diet
• Pancreatitis
• X-ray or CT Scan that involves injecting dye into your veins

Dehydration:
Synjardy can cause dehydration. You should drink plenty of fluids while taking this medication. Inform your doctor if you experience vomiting, diarrhea, or unusual sweating.

Dizziness:
Synjardy may make you dizzy. Avoid getting up too fast from a sitting or lying position. Do not drive or perform any activity that requires alertness until you know how the medicine affects you.

Genital Yeast Infections and UTIs:
Synjardy can increase the risk of genital yeast infections and urinary tract infections in both men and women. Seek medical attention if you develop symptoms.

Kidney Function Monitoring:
Kidney problems can increase the risk of side effects when taking Synjardy. Your doctor will monitor your kidney function before and during treatment with Synjardy. You may have to take Vitamin B12 supplements while using this medication.

Lactic Acidosis Risk:
Lactic acidosis is a dangerous buildup of lactic acid in your blood. The risk of developing this condition increases as you take a medicine containing metformin. Patients with kidney problems, congestive heart failure, dehydration, or those undergoing specific medical procedures are at risk of developing lactic acidosis. Limit your intake of alcohol when taking Synjardy. Alcohol can increase your risk of lactic acidosis.

Low Blood Sugar:
Synjardy can cause low blood sugar, particularly when used in combination with other medications that lower blood sugar, such as insulin or sulfonylureas. Low blood sugar can cause you to feel extremely hungry, dizzy, shaky, or irritable. To quickly treat hypoglycemia, eat or drink hard candy, crackers, raisins, fruit juice, or non-diet soda. Your doctor may prescribe glucagon injections in case of severe hypoglycemia.

Type 1 Diabetes:
Synjardy is only used to treat adults with Type 2 diabetes. Do not use this drug to treat Type 1 diabetes. Vitamin B12:
Vitamin B12 is crucial for maintaining a healthy nervous system and brain function. Long-term use of metformin can lead to a decrease in vitamin B12 levels. Your doctor may monitor your vitamin B12 levels before and during treatment with Synjardy.

Drug Interactions:

Before taking Synjardy, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete information about potential drug interactions, consult the product monograph in Canada: https://pdf.hres.ca/dpd_pm/00069911.PDF, and discuss any concerns with your healthcare provider.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. Synjardy can interact with other medicines but is not limited to aspirin, insulin, diuretics, digoxin, vancomycin, and quinidine.

Pregnancy and Breastfeeding:

If you are pregnant or become pregnant, tell your doctor before using Synjardy. It is unknown if empagliflozin/metformin hydrochloride will harm an unborn baby. It is crucial to discuss the risks and benefits of using Synjardy with your doctor before taking it. Controlling high blood sugar in pregnancy is essential as it can cause complications for both mother and child. If you are breastfeeding or plan to breastfeed, inform your doctor. The excretion of empagliflozin in human milk is unknown. Metformin hydrochloride is excreted in human breast milk and may harm a nursing infant. It is crucial to discuss the risks and benefits of using Synjardy with your doctor before taking it.

Frequently Asked Questions about Synjardy at Canada Pharmacy Online

Why is Synjardy more affordable in Canada than in the United States?

Prescription drug prices, including Synjardy, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

Can I cut or split a Synjardy tablet?

It is generally not recommended to cut, split, or chew Synjardy tablets. Crushing or breaking the tablets can lead to an incorrect dose of the drug and potentially cause adverse effects. Always swallow the tablet whole.

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784. For additional information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Synjardy tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Synjardy at one time, as per your doctor's prescription.

Can I buy Synjardy over the counter from you?

No, Synjardy requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

What is the difference between Synjardy 5 mg/1000mg and 5 mg/500 mg?

The difference in dosage represents the amount of active ingredient(s) present in the drug.

Can I take Synjardy without food?

Take Synjardy with food to reduce the risk of stomach upset

Can I stop taking Synjardy if my symptoms improve?

Do not stop taking Synjardy without consulting your doctor, even if your blood sugar levels are well-controlled, as this can lead to an increase in blood sugar.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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