Tebrazid (Pyrazinamide)

Name: Tebrazid
Brand: Generic
SKU: 6471
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

There is no brand product of Tebrazid.

Generic Equivalent of Tebrazid

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Pyrazinamide Tablet

Manufacturer: Generic

Country: Canada

Dosage: 500 mg

Qty-Price (USD):

Tebrazid Information

Pyrazinamide at CanadaPharmacyOnline.com

The manufacturer of Tebrazid (pyrazinamide) was historically ICN Canada Ltd. (now a part of Bausch Health). Tebrazid is a specialized antibiotic used as a primary defense against tuberculosis. In Canada, brand-name Tebrazid has officially transitioned to a dormant status as of late 2020, meaning it is no longer actively marketed. However, the medication remains a cornerstone of therapy under its generic name. The brand Tebrazid is currently unavailable (at this pharmacy).

Generic pyrazinamide is widely produced by manufacturers that meet Health Canada's strict regulatory standards for safety and quality. Common generic producers include PMS-Pyrazinamide (Pharmascience). Generic pyrazinamide is sourced from manufacturers that meet applicable regulatory standards. However, the specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Pyrazinamide

Generic pyrazinamide contains the same active ingredient as brand-name Tebrazid. It must meet the same effectiveness and quality standards. This means it is designed to work like Tebrazid. Studies have shown that generic pyrazinamide is bioequivalent to brand-name Tebrazid, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Pyrazinamide is available in the following oral strengths and forms:
• Tablets: 500 mg.

The dosage is highly personalized and based on the patient's body weight. The standard adult dose is usually 15 to 30 mg/kg once daily, with a maximum limit of 2 grams per day. Alternatively, it may be prescribed in a twice-weekly regimen of 50 to 70 mg/kg to improve treatment compliance.

Usage:

Tebrazid is a first-line antituberculosis medication used exclusively to treat active tuberculosis (TB). It is always used in combination with other anti-TB drugs, such as isoniazid and rifampin, to prevent the bacteria from developing resistance. Its primary role is to act during the "initial phase" of treatment (usually the first two months) to kill dormant or slow-growing bacteria that other antibiotics might miss. By including Tebrazid in the regimen, the total duration of TB treatment can often be shortened from nine months to six months. It is important to note that Tebrazid only treats bacterial infections; it will not work for viral illnesses like the common cold or flu. Complete the full course of therapy to prevent the infection from returning.

Mechanism of Action
Pyrazinamide is a "prodrug" that requires bacterial activation to work. Once it enters the Mycobacterium tuberculosis cell, it is converted into its active form, pyrazinoic acid, by a bacterial enzyme called pyrazinamidase. This active acid accumulates within the bacteria, lowering the internal pH to a lethal level. This process disrupts the bacterial cell membrane and interferes with essential energy production (ATP synthesis). Furthermore, pyrazinoic acid is thought to block the synthesis of coenzyme A, which the bacteria need to survive. This unique mechanism makes Tebrazid particularly effective in the acidic environment inside human immune cells (macrophages), where TB bacteria often hide.

Take Tebrazid exactly as your doctor prescribes, following the instructions in the package leaflet. You can take it with or without food. To maintain consistent blood levels, take your dose at the same time each day.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Tebrazid, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Tebrazid Side Effects

Side Effects:

The information below outlines potential side effects of Tebrazid (pyrazinamide). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Tebrazid; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Fatigue or unusual tiredness
• Loss of appetite
• Mild joint or muscle pain
• Nausea or vomiting

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat and difficulty breathing.
• Gout Flare-ups: Sudden, severe pain, redness, and swelling in joints, especially the big toe, knee, or ankle.
• Liver Toxicity (Hepatotoxicity): Yellowing of the eyes or skin (jaundice), dark urine, or severe abdominal pain.
• Severe Skin Reactions: A widespread red rash, blistering, or peeling of the skin.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Tebrazid, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Tebrazid/pyrazinamide if:
• Acute Gout: You are currently experiencing a gout attack.
• Allergies: You have a known hypersensitivity to pyrazinamide.
• Severe Liver Disease: You have significant liver damage or active hepatitis.

Tell your doctor about all of your medical conditions, past and present, before starting Tebrazid. This is crucial as certain conditions affect the drug's safety.
• Alcohol Use: Consuming alcohol while taking Tebrazid significantly increases the risk of liver damage.
• Diabetes: This medication can make it harder to stabilize blood sugar levels.
• Kidney Disease: Your doctor may need to adjust your dose or monitor you more closely.
• Porphyria: A rare enzyme disorder that this drug may worsen.

Drug Interactions:

Before taking Tebrazid, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the consumer leaflet at https://www.medsafe.govt.nz/consumers/cmi/p/pyrazinamide-aft.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Tebrazid. Tebrazid may interact with other medicines, including but not limited to:
• Gout Medications: They can interfere with drugs like probenecid or allopurinol, making them less effective at lowering uric acid levels.
• Lab Tests: Tebrazid can interfere with urine ketone tests, potentially causing false results.
• Live Vaccines: It may interfere with the effectiveness of live bacterial vaccines, such as the oral typhoid vaccine.
• Zidovudine (AZT): Levels of this HIV medication may be decreased when taken with Tebrazid.

Pregnancy and Breastfeeding:

Tebrazid is generally used during pregnancy only when clearly needed and the benefits outweigh the risks. While the WHO considers it safe, some guidelines recommend caution due to limited safety data. The drug passes into breast milk. Consult your doctor before breastfeeding, as they may recommend an alternative.

Use in Children:

Tebrazid is safe and routinely used in children for the treatment of active TB. The pediatrician carefully calculates the dose based on the child's body weight.

Frequently Asked Questions about Tebrazid at Canada Pharmacy Online

Why is Tebrazid more affordable in Canada than in the United States?

Prescription drug prices, including Tebrazid, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Tebrazid I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Tebrazid per prescription from your doctor.

Can I buy Tebrazid from you over the counter?

No, Tebrazid requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Tebrazid?

Yes, there is a generic alternative to Tebrazid: pyrazinamide.

Blog Post:

Could Gut Microbiota Help Cure Fungal Infections?

Latest News:

Single vaccine could protect against all coughs, colds and flus, researchers say (news published on February 19, 2026)

Tebrazid Directions

Similar Drugs in the category of Anti-Infective/Antibiotic Medications:

Xifaxan Amoxil Zithromax Oracea Augmentin

The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

Reviews From Real Customers