Temovate (Clobetasol Propionate)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Temovate Ointment

Manufacturer: GSK

Country: Turkey

Dosage: 0.05 %/50 gm

Qty-Price (USD):

Type:

Product: Temovate Ointment

Manufacturer: Taro Pharmaceuticals

Country: Canada

Dosage: 0.05 %/50 gm

Qty-Price (USD):

Generic Equivalent of Temovate

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Clobetasol Propionate Cream

Manufacturer: Generic

Country: Canada

Dosage: 0.05 %/50 gm

Qty-Price (USD):

Type:

Product: Clobetasol Propionate Cream

Manufacturer: Generic

Country: India

Dosage: 0.05 %/30 gm

Qty-Price (USD):

Type:

Product: Clobetasol Propionate Gel

Manufacturer: Generic

Country: Canada

Dosage: 0.05 %/100 gm

Qty-Price (USD):

Type:

Product: Clobetasol Propionate Ointment

Manufacturer: Generic

Country: Canada

Dosage: 0.05 %/50 gm

Qty-Price (USD):

Type:

Product: Clobetasol Propionate Solution

Manufacturer: Generic

Country: Canada

Dosage: 0.05 %/60 ml

Qty-Price (USD):

Temovate Information

medically reviewed by Carol Hou (BSc. Pharm) on June 25, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Temovate and Clobetasol Propionate at CanadaPharmacyOnline.com

The brand Temovate is manufactured and marketed by GSK in several countries, including Canada and Turkey. It is also known as Dermovate.

Generic clobetasol propionate is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Clobetasol Propionate:

Generic clobetasol propionate contains the same active ingredient as brand-name Temovate and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Temovate. Studies have shown that generic clobetasol propionate is bioequivalent to brand-name Temovate, meaning they have similar absorption rates and reach similar concentrations in the bloodstream. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, you can visit the FDA website: https://www.fda.gov/drugs/generic-drugs/generic-drug-facts

Dosage:

The Temovate ointment is typically available in a 0.05% concentration in a 50 g tube (at this pharmacy). The generic clobetasol propionate is available in various formulations and sizes (It may also be available in other sizes depending on the manufacturer and market), including:
• 0.05% cream in 30 gm and 50 gm tubes
• 0.05% gel (commercially available in various tube sizes, or as a pharmacy-compounded preparation, which at this pharmacy is typically in a 100 gm jar)
• 0.05% ointment in a 50 gm tube
• 0.05% solution in a 60 ml bottle

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Temovate, which contains the active ingredient clobetasol propionate, is a super-high-potency topical corticosteroid primarily used to treat various inflammatory and pruritic skin conditions, such as eczema, psoriasis, lichen planus, and some skin manifestations of lupus. As determined by your doctor, it may also be used for other steroid-responsive dermatoses that manifest as redness, swelling, itching, and rashes. Temovate reduces inflammation and itching and suppresses the immune response in the area where it is applied.

Mechanism of Action:
Clobetasol propionate, a potent topical corticosteroid, exerts its effects by binding to intracellular glucocorticoid receptors. This complex translocates to the nucleus, modulating gene expression to increase anti-inflammatory proteins like lipocortin-1 and decrease pro-inflammatory mediators such as prostaglandins, leukotrienes, and cytokines. Consequently, it reduces inflammation through vasoconstriction and suppression of inflammatory mediators. Additionally, clobetasol exhibits immunosuppressive effects by inhibiting immune cell activity and antiproliferative effects by reducing keratinocyte proliferation, effectively treating inflammatory and hyperproliferative skin conditions.

Use Temovate exactly as your doctor prescribes, following the instructions in the Temovate prescribing information | hres.ca. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Temovate, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Temovate (clobetasol propionate). It is not an exhaustive list, and individual reactions can vary.

Common side effects - These are some common side effects of Temovate, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Burning
• Dryness
• Itching
• Redness at the application site
• Stinging

Less common side effects (primarily with prolonged or extensive use, or under occlusion) that may indicate systemic absorption can include:
• Acne
• Excessive hair growth at the application site
• Increased thirst or urination (may be related to potential effects on blood sugar levels with significant systemic absorption)
• Mood changes (such as irritability, anxiety, or depression, potentially related to systemic corticosteroid effects)
• Menstrual irregularities (a less common side effect, potentially occurring with significant systemic absorption)
• Slow wound healing
• Stretch marks
• Thinning or discoloration of the skin
• Unusual tiredness or weakness
• Weight gain, especially in the face and upper body
• Worsening of skin infections

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Allergic reactions (rash, itching, swelling, severe dizziness, trouble breathing)
• Adrenal insufficiency (unusual tiredness, dizziness, fainting, nausea, vomiting - this indicates the body isn't producing enough crucial hormones due to suppression of the hypothalamic-pituitary-adrenal axis)
• Blurred vision, tunnel vision, eye pain, or seeing halos around lights (these can indicate increased pressure within the eye)
• Cushing's syndrome (a hormonal disorder that can be caused by significant systemic absorption of topical corticosteroids, leading to symptoms such as weight gain, round face, high blood pressure, and high blood sugar - this indicates widespread metabolic effects)

Contraindications:

The following is not an exhaustive list of contraindications. Before using Temovate, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Temovate should not be used if you:
• Are allergic to clobetasol propionate or any other ingredients in the formulation
• Have a viral, fungal, or tubercular skin lesion, or any untreated bacterial skin infection, as Temovate can worsen these conditions. • Have rosacea or perioral dermatitis: Temovate should not be used to treat these facial skin conditions
• Have broken or damaged skin: Temovate is generally not recommended for use on broken or damaged skin, cuts, or wounds due to the significantly increased risk of systemic absorption, potential for local irritation, and impaired healing. Use in such areas should only occur under strict medical supervision when the potential benefits outweigh the risks for the specific condition.

Tell your doctor about all of your medical conditions, past and present, before starting Temovate. This is crucial because certain conditions can affect whether Temovate is right for you. These conditions may include, but are not limited to:
• Diabetes: Corticosteroids can increase blood sugar levels, so patients with diabetes should monitor their blood sugar more frequently.
• Diaper rash: Super-high-potency corticosteroids like clobetasol propionate cream are generally contraindicated for treating diaper rash due to the significantly increased risk of systemic absorption and local side effects in this population and application area. Less potent corticosteroids may be considered in severe, refractory cases under strict pediatric dermatological supervision, but non-steroidal treatments are typically preferred.
• Liver disease: Patients with liver disease may have an increased risk of side effects.
• Hyperadrenocorticism (Cushing's syndrome): Topical corticosteroids can be absorbed systemically and potentially worsen this condition.
• Infections: Clobetasol can mask the signs of skin infections and may worsen them. It should not be used on viral, fungal, or tubercular skin lesions.
• Ocular toxicities: Topical corticosteroids may increase the risk of glaucoma and cataracts. Use near the eyes should be avoided unless specifically directed and monitored by your doctor.

Skin Conditions
Clobetasol should not be used on the face, groin, or armpits unless directed by a doctor. Due to increased absorption, these areas are more prone to side effects. It should also be avoided in conditions like acne vulgaris, rosacea, and perioral dermatitis, as it can worsen these conditions.

Drug Interactions:

Before taking Temovate, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the Clobetasol Topical: MedlinePlus Drug Information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Temovate. Temovate may interact with other medicines, but is not limited to:
• Anticoagulants (e.g., Acenocoumarol): While systemic absorption of topical clobetasol propionate is usually minimal with proper use, significant absorption (e.g., with prolonged, widespread use or occlusive dressings) could theoretically affect anticoagulant activity (blood thinning). Discuss with your doctor or pharmacist if you are taking anticoagulants.
• Certain systemic immunosuppressants (e.g., Abatacept, Adalimumab): While systemic absorption of topical clobetasol propionate is usually minimal with proper use, it is always important to inform your doctor about all medications you are taking, as there could be potential additive effects on the immune system with significant systemic absorption.
• Corticosteroids: Using clobetasol with other corticosteroids (oral or topical) may increase the risk of systemic side effects, such as Cushing's syndrome and adrenal suppression, due to increased overall steroid exposure.
• CYP3A4 inducers and inhibitors: While systemic absorption of topical clobetasol propionate is usually minimal with proper use, drugs that significantly inhibit or induce the CYP3A4 enzyme could theoretically alter the systemic levels of absorbed clobetasol, although the clinical significance of this is typically low with proper topical use. Discuss all medications with your doctor or pharmacist.
• Desmopressin: When topical corticosteroids are significantly absorbed systemically, there might be an increased risk of fluid retention. The clinical significance of this interaction is likely low with typical topical use.
• Drugs affecting blood sugar (e.g., Acarbose, Metformin, Insulin): Systemic absorption of clobetasol propionate, while generally minimal with proper topical use, may increase blood sugar levels and affect diabetes management. Patients with diabetes should monitor their blood sugar levels as directed by their physician.
• Other topical medications: It is generally recommended to separate the application of other topical medications from clobetasol to avoid potential interactions or diminished effects.

Latex-containing Products
Certain oil-based excipients, such as mineral oil and petrolatum, found in some topical formulations, including some clobetasol propionate ointments and creams, may weaken latex products like condoms and diaphragms. Exercise caution if using these products concurrently.

Pregnancy and Breastfeeding

Use during pregnancy and breastfeeding should only occur if the potential benefits outweigh the risks. Systemic absorption of topical clobetasol propionate is generally low with typical use, and the risk to the infant via breast milk is considered low but cannot be entirely excluded, especially with prolonged or extensive maternal application. Caution is advised when using Temovate while breastfeeding, and application to the chest area should be avoided to prevent direct infant exposure.

Use in Children

Temovate cream and ointment, containing a super-high-potency corticosteroid, should be used with extreme caution in children and generally only if other less potent corticosteroids have been ineffective. Due to the increased risk of systemic absorption and side effects, use in children under 12 years of age is typically limited to the shortest duration possible and under strict medical supervision.

Frequently Asked Questions about Temovate at Canada Pharmacy Online:

Why is Temovate more affordable in Canada than in the United States?

Prescription drug prices, including Temovate, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tubes I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Temovate at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Temovate requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Temovate?

Yes, there is a generic alternative for this product called clobetasol propionate.

Can I use Temovate on my face, groin, or underarms?

Generally, you should avoid using Temovate on your face, groin, or underarms unless specifically directed by your doctor. Due to increased absorption, these areas are more prone to side effects.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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