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Tobi Podhaler (Tobramycin)

Type
Product
Manufacturer
Country
Dosage
Qty-Price (USD)
Type: drug type
Product: Tobi Podhaler Capsule with Device
Manufacturer: BGP Pharma
Country: Canada
Dosage: 28 mg/224 cap
Qty-Price (USD):

Generic Equivalent of Tobi Podhaler
Type
Product
Manufacturer
Country
Dosage
Qty-Price (USD)
There is no generic product of Tobi Podhaler.

Tobi Podhaler Information

Tobi Podhaler at CanadaPharmacyOnline.com

The manufacturer of Tobi Podhaler (tobramycin inhalation powder) is Novartis Pharmaceuticals. This innovative delivery system was developed to provide a more portable and efficient alternative to traditional liquid nebulizers for cystic fibrosis patients. In Canada, Tobi Podhaler is marketed by Novartis Pharmaceuticals Canada Inc.

Generic tobramycin is currently unavailable (at this pharmacy)

Dosage:

Tobi Podhaler is available in the following strengths and forms:
• Inhalation Capsules: 28 mg of tobramycin per capsule
• Podhaler Device: A plastic inhaler included in the weekly treatment packs.

The standard dose for all patients (adults and children 6 years and older) is 112 mg (4 x 28 mg capsules) twice daily. Take this medication in alternating cycles of 28 days on treatment followed by 28 days off treatment.

Usage:

Tobi Podhaler is a specialized antibiotic used to treat cystic fibrosis in patients with chronic lung infections caused by Pseudomonas aeruginosa. It is designed to suppress these bacteria, improve lung function, and reduce the frequency of "exacerbations" or flare-ups. Unlike liquid nebulizers that can take 15–20 minutes to administer, the Podhaler system typically takes only 2–7 minutes and requires no power source or refrigeration. It is crucial to note that Tobi Podhaler should be the last treatment in a patient's daily respiratory regimen (after bronchodilators and chest physiotherapy). Inhale these capsules using the provided device. Do not swallow them.

Mechanism of Action
Tobramycin, the active agent in Tobi Podhaler, is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. Once inhaled into the lungs, it penetrates the bacterial cell wall and binds to the 30S ribosomal subunit. By attaching to this specific site, it interferes with the bacteria's ability to read the genetic code, leading to the production of "mistranslated" or non-functional proteins. This essentially starves the bacteria of the nutrients they need to grow and maintain their cell membranes, eventually leading to their death. Because the Podhaler delivers the drug as a dry powder directly into the airways, it achieves very high concentrations at the site of infection while keeping levels in the rest of the body relatively low.

Take Tobi Podhaler exactly as your doctor prescribes, following the instructions in the product monograph. Use a new Podhaler device every 7 days (included in the weekly pack) and discard the old one. Do not wash the device with water. Wipe the mouthpiece with a dry cloth.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Tobi Podhaler, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Tobi Podhaler (tobramycin). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Tobi Podhaler; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Altered sense of taste
• Cough (very common during or after inhalation)
• Headache or fever
• Shortness of breath or wheezing
• Sore throat or hoarseness (voice changes)

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face/throat and difficulty breathing.
• Bronchospasm: Severe difficulty breathing or chest tightness immediately after use.
• Hemoptysis: Coughing up significant amounts of blood.
• Nephrotoxicity: Signs of kidney problems, such as decreased urination or swelling in the feet.
• Ototoxicity: Ringing in the ears (tinnitus), hearing loss, or persistent dizziness/vertigo.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Tobi Podhaler, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Tobi Podhaler/tobramycin if:
• Allergies: You have a known hypersensitivity to tobramycin or any other aminoglycoside antibiotic (e.g., gentamicin, amikacin).

Tell your doctor about all of your medical conditions, past and present, before starting Tobi Podhaler. This is crucial as certain conditions affect the drug's safety.
• Hearing or Balance Problems: Aminoglycosides can worsen existing ear damage.
• Kidney Disease: Your doctor may need to monitor your blood levels more closely.
• Low Lung Function: If your FEV1 is less than 25% predicted, safety has not been fully established.
• Neuromuscular Disorders: Conditions like Myasthenia Gravis or Parkinson's disease, as tobramycin can worsen muscle weakness.

Drug Interactions:

Before taking Tobi Podhaler, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the manufacturer’s website at https://www.tobipodhaler.com/en.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Tobi Podhaler. Tobi Podhaler may interact with other medicines, including but not limited to:
• Nephrotoxic/Ototoxic Drugs: Avoid concurrent use with other "heavy hitter" drugs like IV vancomycin, cisplatin, or potent diuretics (e.g., furosemide/Lasix).
• Neuromuscular Blockers: May increase the effects of muscle relaxants used during surgery.
• Other Inhaled Meds: Ensure you follow the correct therapy order (bronchodilators first, Tobi last).

Pregnancy and Breastfeeding

: Tobi Podhaler is generally not recommended during pregnancy because aminoglycosides can cross the placenta and potentially cause permanent deafness in the fetus. If you become pregnant while on this medication, contact your doctor immediately. It is unknown if inhaled tobramycin passes into breast milk. Still, due to potential risks, a decision should be made whether to stop nursing or stop the drug.

Use in Children:

Tobi Podhaler is approved for use in children 6 years of age and older. It is not recommended for children under 6. Caregivers should supervise children (especially those under 10) to ensure they use the device correctly and inhale the full dose from all 4 capsules.

Frequently Asked Questions about Tobi Podhaler at Canada Pharmacy Online

Why is Tobi Podhaler more affordable in Canada than in the United States?

Prescription drug prices, including Tobi Podhaler, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Tobi Podhalers I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Tobi Podhaler per prescription from your doctor.

Can I buy Tobi Podhaler from you over the counter?

No, Tobi Podhaler requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Tobi Podhaler?

No, the generic alternative is currently unavailable (at this pharmacy).

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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Prescriptions Dispensed from Canada are Dispensed by Candrug Pharmacy #18985. 202A 8322-130th Street, Surrey, British Columbia, Canada V3W 8J9, 604-543-8711. Pharmacy Manager: Carol Hou.
This pharmacy is duly licensed in the province of British Columbia, Canada by the College of Pharmacists of BC. If you have any questions or concerns you can contact the college at: 200-1765 West 8th Ave Vancouver, BC V6J 5C6 Canada.
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