Trimethoprim (Trimethoprim)

Name: Trimethoprim
Brand: Generic
SKU: 2141
Availability: InStock

Type

Product

Manufacturer

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Qty-Price (USD)

There is no brand product of Trimethoprim.

Generic Equivalent of Trimethoprim

Type

Product

Manufacturer

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Type:

Product: Trimethoprim (ON BACKORDER)

Manufacturer: Generic

Country: United Kingdom

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Trimethoprim

Manufacturer: Generic

Country: United Kingdom

Dosage: 200 mg

Qty-Price (USD):

Trimethoprim Information

Trimethoprim at CanadaPharmacyOnline.com

The manufacturer of brand-name Proloprim (trimethoprim) was historically GlaxoSmithKline (GSK). While the brand-name Proloprim has a long history, its availability has decreased in many markets, including Canada and the U.S., as high-quality generics have become the standard. The brand Trimethoprim is currently unavailable (at this pharmacy).

Generic trimethoprim is widely produced by various pharmaceutical companies that meet Health Canada's strict regulatory standards for safety and quality. Common generic manufacturers include Teva, Apotex, and Sandoz. Generic trimethoprim is sourced from manufacturers that meet applicable regulatory standards. However, the specific manufacturer of your dispensed medication may vary based on pharmacy inventory.

Important Information about Generic Trimethoprim

Generic trimethoprim contains the same active ingredient as brand-name Trimethoprim. It must meet the same effectiveness and quality standards. This means it is designed to work like Trimethoprim. Studies have shown that generic trimethoprim is bioequivalent to brand-name Trimethoprim, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Trimethoprim is available in the following oral strengths and forms:
• Tablets: 100 mg and 200 mg.

For uncomplicated urinary tract infections (UTIs) in adults, the standard dose is 100 mg every 12 hours or 200 mg once daily for 10 days.

Usage:

Trimethoprim is an antibiotic primarily used to treat and prevent uncomplicated urinary tract infections (UTIs), such as cystitis, caused by susceptible strains of bacteria. It is also sometimes used to treat middle ear infections (otitis media) in children and certain respiratory tract infections. In some cases, it may be prescribed in combination with sulfamethoxazole (as Bactrim or Septra) for a broader range of infections. Because it is an antibiotic, trimethoprim only treats bacterial infections; it will not work for viral illnesses like the common cold or flu. It is essential to complete the full course of treatment as directed by your doctor to ensure the infection is completely eradicated and to prevent antibiotic resistance.

Mechanism of Action
Trimethoprim, the active agent, works by disrupting bacteria's ability to produce essential genetic material. Bacteria need folic acid to synthesize DNA and RNA, which are required for growth and reproduction. Trimethoprim acts as a "dihydrofolate reductase inhibitor." It binds to and blocks a specific enzyme that bacteria use to convert dihydrofolic acid into tetrahydrofolic acid (the active form of folate). By cutting off this supply, the medication starves the bacteria of the building blocks they need to multiply, effectively halting the infection. Because human cells use a different version of this enzyme and can also absorb folate from food, the medication is selectively toxic to bacteria.

Take trimethoprim exactly as your doctor prescribes, following the instructions in the product monograph. You can take it with or without food. Drink plenty of fluids while taking this medication to help flush the bacteria from your urinary system.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Trimethoprim, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Trimethoprim (trimethoprim). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Trimethoprim; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Abnormal taste in the mouth
• Nausea, vomiting, or stomach upset.
• Sensitivity to sunlight
• Skin rash or itching

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat and difficulty breathing.
• Blood Disorders: Signs like unusual bruising, pale skin, sore throat, or fever (which may indicate low blood cell counts).
• Hyperkalemia: High potassium levels, which can cause an irregular heartbeat or muscle weakness.
• Severe Skin Reactions: A red or purple rash that blisters and peels (Stevens-Johnson Syndrome).

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Trimethoprim, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Trimethoprim/trimethoprim if:
• Allergies: You have a known hypersensitivity to trimethoprim.
• Megaloblastic Anemia: Anemia caused by folate deficiency.
• Severe Kidney or Liver Disease: Significant impairment may require avoiding the drug or adjusting the dose.

Tell your doctor about all of your medical conditions, past and present, before starting Trimethoprim. This is crucial as certain conditions affect the drug's safety.
• Folate Deficiency: Chronic illness or malnutrition may increase the risk of blood side effects.
• Kidney Problems: You may need a lower dose to avoid drug buildup.

Drug Interactions:

Before taking Trimethoprim, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the drug data sheet at https://www.medsafe.govt.nz/profs/datasheet/t/tmptab.pdf.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Trimethoprim. Trimethoprim may interact with other medicines, including but not limited to:
• Digoxin: Trimethoprim may increase the levels of this heart medication in your blood.
• Phenytoin: It can increase the levels of this seizure medication.
• Potassium-Sparing Drugs: Like ACE inhibitors (e.g., lisinopril) or spironolactone, which can further increase potassium levels.
• Warfarin: Like many antibiotics, it may increase the blood-thinning effects of warfarin.

Pregnancy and Breastfeeding:

Trimethoprim should be used with caution during pregnancy, especially in the first trimester, as it interferes with folate metabolism, which is critical for fetal development. Components of this medicine pass into breast milk. While small amounts are generally safe, consult your doctor before breastfeeding while on this medication.

Use in Children:

Trimethoprim is safe for use in children aged 2 months and older. The doctor carefully calculates the dose based on the child's weight and age.

Frequently Asked Questions about Trimethoprim at Canada Pharmacy Online

Why is Trimethoprim more affordable in Canada than in the United States?

Prescription drug prices, including Trimethoprim, are generally lower in Canada than in the U.S. due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Trimethoprim I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Trimethoprim per prescription from your doctor.

Can I buy Trimethoprim from you over the counter?

No, Trimethoprim requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Trimethoprim?

Yes, there is a generic alternative to Trimethoprim: trimethoprim.

Blog Post:

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Latest News:

The complicated truth about urinary tract infections in the elderly (article published on December 29, 2025)

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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