Tygacil (Tigecycline)

Name: Tygacil
Brand: Pfizer
SKU: 7582
Availability: InStock

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Tygacil (CURRENTLY UNAVAILABLE)

Manufacturer: Pfizer

Country: Canada

Dosage: 10 mg/ml/5 ml

Qty-Price (USD):

Generic Equivalent of Tygacil

Type

Product

Manufacturer

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Dosage

Qty-Price (USD)

Type:

Product: Tigecycline

Manufacturer: Generic

Country: Canada

Dosage: 10 mg/ml/5 ml

Qty-Price (USD):

Tygacil Information

Tygacil and Tigecycline at CanadaPharmacyOnline.com

The manufacturer of Tygacil (tigecycline) is Pfizer Inc., a global leader in biopharmaceuticals. Developed to combat increasingly resistant bacterial strains, Tygacil is a first-in-class antibiotic that remains a staple in hospital-based critical care. In Canada, brand-name Tygacil is marketed by Pfizer Canada ULC.

While the brand-name version is a primary choice for complex infections, generic tigecycline is produced by several manufacturers that meet Health Canada's strict regulatory standards for quality and safety. Common generic producers include Apotex, Sandoz, and Amneal. Generic tigecycline is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary based on current pharmacy stock.

Important Information about Generic Tigecycline

Generic tigecycline contains the same active ingredient as brand-name Tygacil. It must meet the same effectiveness and quality standards. This means it is designed to work like Tygacil. Studies have shown that generic tigecycline is bioequivalent to brand-name Tygacil, meaning it has similar absorption and achieves comparable blood concentrations. However, individual responses to medication can vary due to factors such as metabolism, genetics, and other health conditions.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Tygacil (tigecycline) is available in the following strengths and forms:
• Powder for Solution (Vial): 10 mg/ml/5 ml

In adults, the recommended dosing regimen typically begins with an initial loading dose of 100 mg, followed by 50 mg every 12 hours. The medication is administered only by intravenous (IV) infusion over 30 to 60 minutes. Treatment usually lasts between 5 and 14 days, depending on the severity and site of the infection.

Usage:

Tygacil is a powerful glycylcycline antibiotic specifically reserved for treating complicated infections that may be resistant to other treatments. It is primarily used to treat complicated skin and soft tissue infections (cSSTI) and complicated intra-abdominal infections (cIAI). Additionally, it is indicated for community-acquired bacterial pneumonia (CABP). Because it is a broad-spectrum antibiotic, it can eliminate a wide range of bacteria, including difficult-to-treat strains like MRSA (methicillin-resistant Staphylococcus aureus). However, Tygacil is not indicated for diabetic foot infections or hospital-acquired pneumonia. As an antibiotic, it treats only bacterial infections and is ineffective against viral illnesses like the common cold or flu. Due to a risk of increased mortality compared to other antibiotics, Tygacil is typically used only when other treatment options are not suitable.

Mechanism of Action
Tigecycline, the active ingredient in Tygacil, inhibits bacterial growth and reproduction. It belongs to the glycylcycline class, which is structurally related to tetracyclines but designed to overcome common bacterial resistance mechanisms. It acts as a protein synthesis inhibitor by binding to the 30S subunit of the bacterial ribosome. By physically blocking the entry of aminoacyl-tRNA molecules into the ribosome, the drug prevents the bacteria from adding new amino acids to their peptide chains. This stops the production of essential proteins required for bacterial multiplication. Tigecycline's unique structure allows it to bind more effectively than older tetracyclines, enabling it to evade the "efflux pumps" and "ribosomal protection proteins" that many bacteria use to resist other antibiotics.

Healthcare professionals administer Tygacil in a hospital or clinical setting, according to the product monograph. If you are receiving this medication, it is essential to complete the full course of treatment to prevent the infection from returning or the development of antibiotic resistance.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before starting Tygacil, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects of Tygacil (tigecycline). It is not an exhaustive list, and individual reactions can vary.

Common side effects: These are common side effects of Tygacil; other side effects are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Changes in the way things taste
• Diarrhea or stomach pain
• Dizziness
• Headache
• Nausea (the most common side effect) and vomiting

Serious Side Effects: Seek immediate medical attention or call emergency services if you experience any of the following symptoms:
• All-Cause Mortality: An increased risk of death has been observed in patients treated with Tygacil compared to other antibiotics; discuss this "Black Box Warning" with your doctor.
• Anaphylaxis: Severe allergic reaction involving swelling of the face, tongue, or throat and difficulty breathing.
• C. diff-associated Diarrhea: Severe, watery, or bloody diarrhea with fever.
• Increased Intracranial Pressure: Severe headache, vision changes, or ringing in the ears.
• Liver Problems: Yellowing of the eyes/skin (jaundice), dark urine, or severe right-sided abdominal pain.
• Pancreatitis: Severe pain in the upper stomach that may spread to the back, often with nausea and vomiting.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Tygacil, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Do not take Tygacil/tigecycline if:
• Age: Tygacil should not be used in children under 8 years old due to the risk of permanent tooth discoloration.
• Allergies: You have a known hypersensitivity to tigecycline or other tetracycline antibiotics.

Tell your doctor about all of your medical conditions, past and present, before starting Tygacil. This is crucial as certain conditions affect the drug's safety.
• Blood Coagulation Issues: Tygacil can prolong blood clotting times; your doctor will monitor your prothrombin time (PT).
• Intestinal Problems: Tell your doctor if you have a history of colitis.
• Severe Liver Disease: The maintenance dose may need to be reduced to 25 mg every 12 hours in patients with severe hepatic impairment (Child-Pugh C).

Drug Interactions:

Before taking Tygacil, discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, please visit the highlights of prescribing information at https://labeling.pfizer.com/showlabeling.aspx?id=491.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, herbal supplements, recreational drugs, and any significant dietary changes, as these may interact with Tygacil. Tygacil may interact with other medicines, including but not limited to:
• IV Incompatibilities: Certain drugs, such as diazepam and esomeprazole, should not be administered through the same IV line as Tygacil.
• Live Vaccines: It may interfere with the effectiveness of live bacterial vaccines (e.g., the typhoid vaccine).
• Oral Contraceptives: Antibiotics may slightly decrease the effectiveness of birth control pills; consider a backup method.
• Tacrolimus or cyclosporine: Tygacil can increase blood levels of certain transplant medications, which requires close monitoring.
• Warfarin: Tygacil may increase the blood-thinning effect of warfarin, increasing the risk of bleeding.

Pregnancy and Breastfeeding:

Tygacil is not recommended during pregnancy, as it can cause permanent tooth discoloration and enamel defects in the fetus. It should be used only if the potential benefit justifies the risk. It is unknown if tigecycline passes into breast milk; due to potential risks to the infant, breastfeeding is generally discouraged during treatment.

Use in Children:

While some international bodies approve Tygacil for children aged 8 years and older, Health Canada authorizes its use for children aged 18 years and older. It is avoided in younger children to prevent permanent yellowing or graying of the teeth.

Frequently Asked Questions about Tygacil at Canada Pharmacy Online

Why is Tygacil more affordable in Canada than in the United States?

Prescription drug prices, including Tygacil, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower prices than in the US, where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy is dedicated to offering you the lowest prices on high-quality products.

How do I place an order with your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many Tygacil I can order at once?

CanadaPharmacyOnline.com can dispense up to a three-month supply of Tygacil per prescription from your doctor.

Can I buy Tygacil from you over the counter?

No, Tygacil requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes between 7 and 18 business days to receive your order from our pharmacy.

Is there a generic for Tygacil?

Yes, there is a generic alternative to Tygacil: tigecycline.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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