Wellbutrin SR (Bupropion Hydrochloride ER Tablet)

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Wellbutrin SR

Manufacturer: GSK

Country: New Zealand

Dosage: 150 mg

Qty-Price (USD):

Type:

Product: Wellbutrin SR (Zyban)

Manufacturer: Bausch Health

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Generic Equivalent of Wellbutrin SR

Type

Product

Manufacturer

Country

Dosage

Qty-Price (USD)

Type:

Product: Bupropion Hydrochloride ER Tablet

Manufacturer: Generic

Country: Canada

Dosage: 100 mg

Qty-Price (USD):

Type:

Product: Bupropion Hydrochloride ER Tablet

Manufacturer: Generic

Country: Canada

Dosage: 150 mg

Qty-Price (USD):

Wellbutrin SR Information

medically reviewed by Carol Hou (BSc. Pharm) on June 19, 2025.

A licensed pharmacist (Licensed Community Pharmacies Directory | College of Pharmacists of British Columbia) with over 20 years of experience in medication management, specifically medication safety, she has reviewed the information for accuracy and completeness.

Wellbutrin SR and Bupropion Hydrochloride Sustained-Release at CanadaPharmacyOnline.com

Wellbutrin SR is a brand name for bupropion hydrochloride sustained-release, primarily manufactured by GlaxoSmithKline (GSK) and marketed in Canada by Bausch Health. Zyban is another brand name for bupropion hydrochloride sustained-release, specifically indicated for smoking cessation and also marketed in Canada.

Generic bupropion hydrochloride sustained-release is sourced from manufacturers that meet applicable regulatory standards. The specific manufacturer of your dispensed medication may vary.

Important Information about Generic Bupropion Hydrochloride Sustained-Release:

Generic bupropion hydrochloride sustained-release contains the same active ingredient as brand-name Wellbutrin SR and is required to meet the same safety, effectiveness, and quality standards. This means it is designed to work in the same way as Wellbutrin SR. Studies have demonstrated bioequivalence between generic and brand-name bupropion hydrochloride sustained-release, meaning they have comparable absorption rates and overall effects. However, individual responses to any medication can vary. Talk to your doctor or pharmacist if you have any questions about using generic bupropion hydrochloride sustained-release.

For more information about generic drug approval and bioequivalence, please visit Access to Generic Drugs in Canada | Canada.ca.

Dosage:

Brand Wellbutrin SR and generic bupropion hydrochloride sustained-release are commonly available in 150 mg oral tablets.

The generic bupropion hydrochloride sustained-release is available in 100 mg oral tablets.

Your doctor will determine the appropriate dose based on your individual needs and medical conditions.

Usage:

Wellbutrin SR (bupropion hydrochloride sustained-release) is a prescription medication used to treat major depressive disorder (MDD). Wellbutrin SR is an antidepressant that helps to restore the balance of certain natural substances (neurotransmitters) in the brain, specifically dopamine and norepinephrine, which play a role in regulating mood.

Mechanism of Action:
Wellbutrin SR (bupropion hydrochloride sustained-release) is an atypical antidepressant that exerts its primary therapeutic effects by acting as a norepinephrine-dopamine reuptake inhibitor (NDRI). This means it blocks the reabsorption (reuptake) of the neurotransmitters norepinephrine and dopamine by neurons in the brain, leading to increased levels of these active chemical messengers in the synaptic cleft. The resulting increase in norepinephrine and dopamine neurotransmission is believed to contribute to its antidepressant and other therapeutic effects, although the precise neurobiological mechanisms underlying these benefits are still being investigated. Notably, Wellbutrin SR has minimal impact on serotonin levels, distinguishing it from many other antidepressants.

Take Wellbutrin SR exactly as your doctor prescribes, following the instructions in the product monograph in Canada. Consult your doctor for personalized guidance and safe use.

The information below summarizes some, but not all, potential side effects, risks, and interactions. Before taking Wellbutrin SR, it is essential to discuss all possible side effects, risks, and interactions with your doctor or pharmacist.

Side Effects:

The information below outlines potential side effects associated with Wellbutrin SR (bupropion hydrochloride sustained-release). It is not an exhaustive list, and individual reactions can vary.

Common Side Effects - These are some common side effects of Wellbutrin SR, generally mild and may go away as your body adjusts to the medication, but others are possible. Contact your doctor promptly if any side effects are persistent, worsening, or concerning, or if you experience any other concerning symptoms.
• Agitation
• Anxiety or nervousness
• Blurred vision
• Changes in weight (weight loss is more common than weight gain)
• Changes in libido (sex drive)
• Constipation
• Dizziness
• Dry mouth
• Fast heartbeat or palpitations
• Headache
• Increased urination
• Loss of appetite
• Muscle or joint pain
• Nausea or vomiting
• Ringing in the ears (tinnitus)
• Runny or stuffy nose
• Sore throat
• Strange taste in the mouth
• Stomach pain
• Sweating
• Tremor (shaking)
• Trouble sleeping (insomnia)

Serious Side Effects: These are rare but potentially severe side effects. Seek immediate medical attention or call emergency services if you experience any of the following:
• Angle-Closure Glaucoma: Wellbutrin can increase pressure inside the eye, potentially leading to a sudden onset of eye pain, changes in vision (blurred vision, seeing halos around lights), and redness in or around the eye.
• Heart Problems: Fast or irregular heartbeats, chest pain, shortness of breath, dizziness, or fainting.
• Increased Blood Pressure (Hypertension): Wellbutrin can raise blood pressure or worsen existing high blood pressure.
• Mania or Hypomania: In people with bipolar disorder, Wellbutrin may trigger manic or hypomanic episodes characterized by very increased energy, racing thoughts, reckless behavior, and extreme happiness or irritability.
• Seizures: Wellbutrin can increase the risk of seizures, especially at higher doses or in individuals with a history of seizures or certain medical conditions.
• Severe Allergic Reactions: Symptoms can include rash, itching, hives, swelling of the face, lips, tongue, or throat, difficulty breathing, and fever. • Severe Headache: Especially if sudden and accompanied by chest pain, dizziness, confusion, vision changes, nausea, or vomiting.
• Severe Skin Reactions: Such as fever, sore throat, burning eyes, skin pain, or a red or purple skin rash with blistering and peeling.
• Suicidal Thoughts and Actions: Wellbutrin, like other antidepressants, can increase the risk of suicidal thoughts and behaviors in some people, especially children, adolescents, and young adults (up to age 24), particularly when starting the medication or when the dose is changed.
• Unusual Thoughts or Behavior: This can include delusions, hallucinations, paranoia, confusion, and aggression.

Contraindications:

The following is not an exhaustive list of contraindications. Before starting Wellbutrin SR, it is crucial to discuss all your medical conditions, past and present, and all medications you are taking with your doctor or pharmacist.

Wellbutrin SR should not be used if you:
• Allergy to bupropion or any of its ingredients: An allergic reaction can be serious.
• Abruptly stopped drinking alcohol: Sudden alcohol withdrawal can increase the risk of seizures, and Wellbutrin SR can further lower the seizure threshold.
• Abruptly stopping certain medications, such as benzodiazepines, barbiturates, or some antiepileptic drugs, can increase seizure risk due to central nervous system hyperexcitability.
• Angle-closure glaucoma: Wellbutrin SR can dilate pupils, potentially triggering an acute angle-closure glaucoma attack.
• Bipolar disorder: Wellbutrin SR is not approved for treating bipolar depression and may increase the risk of mania or hypomania.
• Current or past diagnosis of an eating disorder, such as bulimia or anorexia nervosa: These conditions increase the risk of seizures.
• Seizure disorder or a history of seizures: Wellbutrin SR can lower the seizure threshold, making seizures more likely.

Tell your doctor about your medical conditions, past and present, before starting Wellbutrin SR. This is crucial because certain conditions affect whether Wellbutrin SR is right for you. These conditions may include, but are not limited to:
• Anxiety or agitation: While Wellbutrin SR can treat depression, it can sometimes worsen anxiety in some people.
• Diabetes: Wellbutrin SR can affect blood sugar control in some individuals.
• Glaucoma: Specifically, angle-closure glaucoma, as Wellbutrin SR can dilate pupils
. • Head injury or brain tumor: These conditions can increase the risk of seizures.
• Heart problems: Such as high blood pressure, heart attack, chest pain, or irregular heartbeat.
• Kidney or liver problems: These conditions can affect how your body processes the medication
• Stroke: A history of stroke may influence the decision to prescribe Wellbutrin SR.
• Suicidal thoughts or behaviors: If you have experienced these in the past or are currently having them.

Drug Interactions:

Before taking Wellbutrin SR, it is essential to discuss all potential risks and interactions with your doctor or pharmacist. For complete and up-to-date information, refer to the official Wellbutrin SR prescribing information.

Provide your doctor with a complete list of all your medications, including prescriptions, over-the-counter (OTC) drugs, vitamins, and herbal supplements. It is also important to inform your doctor about any herbal teas, recreational drugs, or significant dietary changes you are making, as these could potentially interact with Wellbutrin SR. Wellbutrin SR may interact with other medicines, but is not limited to:
• Antipsychotics: Especially thioridazine.
• Certain medications that can lower the seizure threshold: This includes some other antidepressants, antipsychotics, stimulants, and certain pain medications.
• Herbal supplements: Such as St. John's Wort, which can interact with antidepressants.
• Medications that affect dopamine or norepinephrine levels: As Wellbutrin SR also affects these neurotransmitters.
• Monoamine oxidase inhibitors (MAOIs): Including medications like phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan), selegiline (Emsam, Zelapar), and linezolid (Zyvox). You should also mention if you have taken an MAOI in the past 14 days.
• Nicotine replacement therapy: If you are also using patches, gum, or lozenges to quit smoking.
• Other medications containing bupropion: Such as Zyban (for smoking cessation) or Wellbutrin XL.
• Other antidepressants: Selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), etc.

Alcohol: It is generally recommended to limit or avoid alcohol while taking Wellbutrin SR. Alcohol can increase the risk of certain side effects, including seizures.

Pregnancy or Breastfeeding:

Wellbutrin SR use during pregnancy and breastfeeding requires a doctor's consultation. Some studies suggest a small potential risk during pregnancy, and it's not typically the first choice. Newborns may have temporary withdrawal symptoms with late-pregnancy use. Bupropion passes into breast milk and is generally not expected to harm infants, though rare seizure cases exist. Discuss risks and benefits with your doctor for personalized guidance.

Frequently Asked Questions about Wellbutrin SR at Canada Pharmacy Online:

Why is Wellbutrin SR more affordable in Canada than in the United States?

Prescription drug prices, including Wellbutrin SR, are generally lower in Canada than in the US due to a combination of factors, primarily government price regulations, differing market dynamics, and other economic considerations. In Canada, provincial and federal governments negotiate drug prices with pharmaceutical companies, which often results in lower costs compared to the U.S., where market forces play a more significant role. For more information, see the FAQs on Prescription Drug Importation from the Kaiser Family Foundation (KFF): https://www.kff.org/health-costs/issue-brief/faqs-on-prescription-drug-importation/

How much is the shipping?

Our shipping fee is a flat rate of $10.00 per order. Our pharmacy focuses on offering you the lowest prices on high-quality products.

How do I order from your pharmacy?

Ordering from us is very simple. You can purchase online or call Customer Service at 1866.920.3784; for more information or to learn about the ordering process, visit our How to Order page.

Is there a limit on how many tablets I am allowed to order at one time?

CanadaPharmacyOnline.com can only dispense a maximum of a three-month supply of Wellbutrin SR at once, per your doctor's prescription.

Can I buy over the counter from you?

No, Wellbutrin SR requires a valid prescription from your doctor. We do not sell this product without a valid prescription.

Do you ship to the United States?

Yes, we do. It usually takes 7 to 18 business days to receive your order from our pharmacy.

Is there a generic for Wellbutrin SR?

Yes, a generic alternative for this product is bupropion hydrochloride sustained-release.

How long does it take for Wellbutrin SR to work?

It may take several weeks for you to notice the full benefits of Wellbutrin SR. Continue taking the medication as prescribed, even if you don't feel better right away. Do not stop taking it without talking to your doctor, as suddenly stopping the medication can lead to withdrawal symptoms.

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The information on this page is sourced from independent third parties contracted by CanadaPharmacyOnline. While we cannot guarantee its medical accuracy, we strongly recommend consulting a healthcare professional for personalized advice regarding medications or medical conditions.

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